A case of meropenem-induced liver injury and jaundice
This report describes what we believe is the first reported case of clinically significant cholestasis and acute liver injury within three days of meropenem therapy. An 83-year-old Hispanic female was admitted for sepsis of unknown origin and was started on intravenous meropenem. Three days followin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Greater Baltimore Medical Center
2021-01-01
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| Series: | Journal of Community Hospital Internal Medicine Perspectives |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20009666.2020.1845929 |
| _version_ | 1797972301802635264 |
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| author | Szeya Cheung Jennifer Bulovic Ajish Pillai Trehan Manoj Katriyar Neeraj |
| author_facet | Szeya Cheung Jennifer Bulovic Ajish Pillai Trehan Manoj Katriyar Neeraj |
| author_sort | Szeya Cheung |
| collection | DOAJ |
| description | This report describes what we believe is the first reported case of clinically significant cholestasis and acute liver injury within three days of meropenem therapy. An 83-year-old Hispanic female was admitted for sepsis of unknown origin and was started on intravenous meropenem. Three days following initiation of the antibiotic, the patient developed mixed hepatocellular and cholestatic liver injury with jaundice and pruritus. Possible causes of cholestasis were excluded after extensive investigations. A drug-induced liver injury was suspected and meropenem was discontinued. Following discontinuation of meropenem, the patient demonstrated symptomatic and laboratory improvements, and her liver enzymes and bilirubin levels were normalized. |
| first_indexed | 2024-04-11T03:46:21Z |
| format | Article |
| id | doaj.art-50f1ad054cb649fea9dddbc4a2d2d6e3 |
| institution | Directory Open Access Journal |
| issn | 2000-9666 |
| language | English |
| last_indexed | 2024-04-11T03:46:21Z |
| publishDate | 2021-01-01 |
| publisher | Greater Baltimore Medical Center |
| record_format | Article |
| series | Journal of Community Hospital Internal Medicine Perspectives |
| spelling | doaj.art-50f1ad054cb649fea9dddbc4a2d2d6e32023-01-02T02:39:46ZengGreater Baltimore Medical CenterJournal of Community Hospital Internal Medicine Perspectives2000-96662021-01-0111114314410.1080/20009666.2020.18459291845929A case of meropenem-induced liver injury and jaundiceSzeya Cheung0Jennifer Bulovic1Ajish Pillai2Trehan Manoj3Katriyar Neeraj4Long Island Community HospitalLong Island Community HospitalLong Island Community HospitalLong Island Community HospitalLong Island Community HospitalThis report describes what we believe is the first reported case of clinically significant cholestasis and acute liver injury within three days of meropenem therapy. An 83-year-old Hispanic female was admitted for sepsis of unknown origin and was started on intravenous meropenem. Three days following initiation of the antibiotic, the patient developed mixed hepatocellular and cholestatic liver injury with jaundice and pruritus. Possible causes of cholestasis were excluded after extensive investigations. A drug-induced liver injury was suspected and meropenem was discontinued. Following discontinuation of meropenem, the patient demonstrated symptomatic and laboratory improvements, and her liver enzymes and bilirubin levels were normalized.http://dx.doi.org/10.1080/20009666.2020.1845929drug-induced liver injuryantibiotic-induced liver injuryantibiotic-induced jaundicemeropenem-induced cholestatic jaundice |
| spellingShingle | Szeya Cheung Jennifer Bulovic Ajish Pillai Trehan Manoj Katriyar Neeraj A case of meropenem-induced liver injury and jaundice Journal of Community Hospital Internal Medicine Perspectives drug-induced liver injury antibiotic-induced liver injury antibiotic-induced jaundice meropenem-induced cholestatic jaundice |
| title | A case of meropenem-induced liver injury and jaundice |
| title_full | A case of meropenem-induced liver injury and jaundice |
| title_fullStr | A case of meropenem-induced liver injury and jaundice |
| title_full_unstemmed | A case of meropenem-induced liver injury and jaundice |
| title_short | A case of meropenem-induced liver injury and jaundice |
| title_sort | case of meropenem induced liver injury and jaundice |
| topic | drug-induced liver injury antibiotic-induced liver injury antibiotic-induced jaundice meropenem-induced cholestatic jaundice |
| url | http://dx.doi.org/10.1080/20009666.2020.1845929 |
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