Redox environment is an intracellular factor to operate distinct pathways for aggregation of Cu,Zn-superoxide dismutase in amyotrophic lateral sclerosis

Redox environment is an intracellular factor to operate distinct pathways for aggregation of Cu,Zn-superoxide dismutase in amyotrophic lateral sclerosis

Dominant mutations in Cu,Zn-superoxide dismutase (SOD1) cause a familial form of amyotrophic lateral sclerosis (fALS). Misfolding and aggregation of mutant SOD1 proteins are a pathological hallmark of SOD1-related fALS cases; however, the molecular mechanism of SOD1 aggregation remains controversia...

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Bibliographic Details
Main Author:	Yoshiaki eFurukawa
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2013-11-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	Amyloid Aggregation ALS SOD1 disulfide bond
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00240/full

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