Speeding Up the Identification of Cystic Fibrosis Transmembrane Conductance Regulator-Targeted Drugs: An Approach Based on Bioinformatics Strategies and Surface Plasmon Resonance

Speeding Up the Identification of Cystic Fibrosis Transmembrane Conductance Regulator-Targeted Drugs: An Approach Based on Bioinformatics Strategies and Surface Plasmon Resonance

Cystic fibrosis (CF) is mainly caused by the deletion of Phe 508 (ΔF508) in the cystic fibrosis transmembrane conductance regulator (CFTR) protein that is thus withheld in the endoplasmic reticulum and rapidly degraded by the ubiquitin/proteasome system. New drugs able to rescue ΔF508-CFTR trafficki...

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Bibliographic Details
Main Authors: Marco Rusnati, Davide Sala, Alessandro Orro, Antonella Bugatti, Gabriele Trombetti, Elena Cichero, Chiara Urbinati, Margherita Di Somma, Enrico Millo, Luis J. V. Galietta, Luciano Milanesi, Paola Fossa, Pasqualina D’Ursi
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Molecules
Subjects:
cystic fibrosis
computational chemistry
molecular dynamics
molecular modeling
surface plasmon resonance
Online Access:http://www.mdpi.com/1420-3049/23/1/120

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