Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis
Abstract Background Knee osteoarthritis (OA) is a complex arthritic condition in which genetic factors play an important role. ADAM12 gene is one of the recognized candidate genes although the results are conflicting. To derive a more precise estimation of the association between rs3740199 polymorph...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13018-017-0594-z |
| _version_ | 1798027053169115136 |
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| author | Zheng Hao Xin Li Jin Dai Baocheng Zhao Qing Jiang |
| author_facet | Zheng Hao Xin Li Jin Dai Baocheng Zhao Qing Jiang |
| author_sort | Zheng Hao |
| collection | DOAJ |
| description | Abstract Background Knee osteoarthritis (OA) is a complex arthritic condition in which genetic factors play an important role. ADAM12 gene is one of the recognized candidate genes although the results are conflicting. To derive a more precise estimation of the association between rs3740199 polymorphism in ADAM12 gene and risk of knee OA, we performed a meta-analysis based on six related studies, including a total of 2185 cases and 3716 controls. Methods A comprehensive search was performed to identify related studies up to April 14, 2017. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Different genetic models were used to assess the pooled and stratified data. Results Overall, no significant association was found in all genetic models (C vs. G, OR = 0.983, 95% CI = 0.910–1.061; CC vs. GG, OR = 1.033, 95% CI = 0.851–1.255; CG vs. GG, OR = 1.030, 95% CI = 0.877–1.209; CC/CG vs. GG, OR = 1.031, 95% CI = 0.886–1.201; CC vs. CG/GG, OR = 1.017, 95% CI = 0.868–1.190). When stratified by ethnicity, no significant association was found. Conclusions This meta-analysis suggested that the rs3740199 polymorphism does not contribute to the development of knee OA. Additional well-designed large studies are required to confirm these findings in different populations. |
| first_indexed | 2024-04-11T18:45:05Z |
| format | Article |
| id | doaj.art-50f8b8efc2f74e01a0818fc0c041b5a3 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T18:45:05Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-50f8b8efc2f74e01a0818fc0c041b5a32022-12-22T04:08:51ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2017-06-011211710.1186/s13018-017-0594-zGenetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysisZheng Hao0Xin Li1Jin Dai2Baocheng Zhao3Qing Jiang4Center of Diagnosis and Treatment for Developmental Dysplasia of the Hip, Nanjing Zhongyangmen Community Health Service Center, Kang’ai HospitalDepartment of HIV/AIDS/STI Prevention and Control, Nanjing Municipal Center for Diseases Control and PreventionDepartment of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, School of Medicine, Nanjing UniversityCenter of Diagnosis and Treatment for Developmental Dysplasia of the Hip, Nanjing Zhongyangmen Community Health Service Center, Kang’ai HospitalDepartment of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, School of Medicine, Nanjing UniversityAbstract Background Knee osteoarthritis (OA) is a complex arthritic condition in which genetic factors play an important role. ADAM12 gene is one of the recognized candidate genes although the results are conflicting. To derive a more precise estimation of the association between rs3740199 polymorphism in ADAM12 gene and risk of knee OA, we performed a meta-analysis based on six related studies, including a total of 2185 cases and 3716 controls. Methods A comprehensive search was performed to identify related studies up to April 14, 2017. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Different genetic models were used to assess the pooled and stratified data. Results Overall, no significant association was found in all genetic models (C vs. G, OR = 0.983, 95% CI = 0.910–1.061; CC vs. GG, OR = 1.033, 95% CI = 0.851–1.255; CG vs. GG, OR = 1.030, 95% CI = 0.877–1.209; CC/CG vs. GG, OR = 1.031, 95% CI = 0.886–1.201; CC vs. CG/GG, OR = 1.017, 95% CI = 0.868–1.190). When stratified by ethnicity, no significant association was found. Conclusions This meta-analysis suggested that the rs3740199 polymorphism does not contribute to the development of knee OA. Additional well-designed large studies are required to confirm these findings in different populations.http://link.springer.com/article/10.1186/s13018-017-0594-zOsteoarthritisADAM12rs3740199PolymorphismMeta-analysis |
| spellingShingle | Zheng Hao Xin Li Jin Dai Baocheng Zhao Qing Jiang Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis Journal of Orthopaedic Surgery and Research Osteoarthritis ADAM12 rs3740199 Polymorphism Meta-analysis |
| title | Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis |
| title_full | Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis |
| title_fullStr | Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis |
| title_full_unstemmed | Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis |
| title_short | Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis |
| title_sort | genetic effects of rs3740199 polymorphism in adam12 gene on knee osteoarthritis a meta analysis |
| topic | Osteoarthritis ADAM12 rs3740199 Polymorphism Meta-analysis |
| url | http://link.springer.com/article/10.1186/s13018-017-0594-z |
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