Corneal remodeling after SMILE for moderate and high myopia: short-term assessment of spatial changes in corneal volume and thickness
Abstract Purpose To evaluate the early corneal remodeling and its influencing factors after Small incision lenticule extraction (SMILE) for moderate and high myopia. Methods This was a retrospective study. Pre- and post-operative (1 week and 1, 3, 6 months) corneal volume (CV), mean keratometry (Km)...
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| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-023-03148-0 |
| _version_ | 1797577369003753472 |
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| author | Yuanpeng Wu Ting Shen Lingtong Tan Ting He Qingqing Zheng Chaoyang Hong |
| author_facet | Yuanpeng Wu Ting Shen Lingtong Tan Ting He Qingqing Zheng Chaoyang Hong |
| author_sort | Yuanpeng Wu |
| collection | DOAJ |
| description | Abstract Purpose To evaluate the early corneal remodeling and its influencing factors after Small incision lenticule extraction (SMILE) for moderate and high myopia. Methods This was a retrospective study. Pre- and post-operative (1 week and 1, 3, 6 months) corneal volume (CV), mean keratometry (Km), and corneal thickness (CT) were measured by Scheimpflug tomography. CT at the central, thinnest point, and on concentric circles of 2, 4, and 6 mm diameter was recorded to assess corneal thickness spatial profile (CTSP) and percentage of thickness increase (PTI) in the moderate and high myopia groups, and to explore possible influencing factors. Results After SMILE, the peripheral CT decreased in the moderate myopia group and central corneal thickness (CCT) increased in the high myopia group at 1 month compared to 1 week (all P < 0.05). The CV, Km and CT were significantly increased at 3 months compared to 1 month (all P < 0.05), but there was no significant change at 6 months compared to 3 months for both groups (all P > 0.05). Patients with high myopia showed greater corneal thickness changes (△CT) and higher PTI than moderate myopia (all P < 0.05). Regression analysis revealed that in addition to refraction, peripheral PTI was negatively correlated with CCT in the moderate myopia group (4 mm: β = -0.023, P = 0.001; 6 mm: β = -0.050, P < 0.001), as well as in the high myopia group (4 mm: β = -0.038, P < 0.001; 6 mm: β = -0.094, P < 0.001). Moreover, peripheral PTI in the moderate myopia group was negatively correlated with age (4 mm: β = -0.071, P = 0.003; 6 mm: β = -0.162, P < 0.001). Conclusions After SMILE, the CV, Km, and CTSP showed dynamic changes in the early stage, which stabilized after 3 months. Compared to the moderate myopia group, the high myopia group experienced slower corneal stabilization. The change in PTI at 6 months after SMILE may be related to higher preoperative refraction, thinner CCT and younger age. |
| first_indexed | 2024-03-10T22:07:17Z |
| format | Article |
| id | doaj.art-50fa1f5436c14e0ebba4be7fd66715b0 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-03-10T22:07:17Z |
| publishDate | 2023-10-01 |
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| series | BMC Ophthalmology |
| spelling | doaj.art-50fa1f5436c14e0ebba4be7fd66715b02023-11-19T12:45:09ZengBMCBMC Ophthalmology1471-24152023-10-0123111010.1186/s12886-023-03148-0Corneal remodeling after SMILE for moderate and high myopia: short-term assessment of spatial changes in corneal volume and thicknessYuanpeng Wu0Ting Shen1Lingtong Tan2Ting He3Qingqing Zheng4Chaoyang Hong5School of Public Health, Hangzhou Medical CollegeEye Center, the Second Affiliated Hospital, Zhejiang University School of MedicineSchool of Ophthalmology and Optometry, Wenzhou Medical UniversitySchool of Public Health, Hangzhou Medical CollegeDepartment of Ophthalmology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical CollegeDepartment of Ophthalmology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical CollegeAbstract Purpose To evaluate the early corneal remodeling and its influencing factors after Small incision lenticule extraction (SMILE) for moderate and high myopia. Methods This was a retrospective study. Pre- and post-operative (1 week and 1, 3, 6 months) corneal volume (CV), mean keratometry (Km), and corneal thickness (CT) were measured by Scheimpflug tomography. CT at the central, thinnest point, and on concentric circles of 2, 4, and 6 mm diameter was recorded to assess corneal thickness spatial profile (CTSP) and percentage of thickness increase (PTI) in the moderate and high myopia groups, and to explore possible influencing factors. Results After SMILE, the peripheral CT decreased in the moderate myopia group and central corneal thickness (CCT) increased in the high myopia group at 1 month compared to 1 week (all P < 0.05). The CV, Km and CT were significantly increased at 3 months compared to 1 month (all P < 0.05), but there was no significant change at 6 months compared to 3 months for both groups (all P > 0.05). Patients with high myopia showed greater corneal thickness changes (△CT) and higher PTI than moderate myopia (all P < 0.05). Regression analysis revealed that in addition to refraction, peripheral PTI was negatively correlated with CCT in the moderate myopia group (4 mm: β = -0.023, P = 0.001; 6 mm: β = -0.050, P < 0.001), as well as in the high myopia group (4 mm: β = -0.038, P < 0.001; 6 mm: β = -0.094, P < 0.001). Moreover, peripheral PTI in the moderate myopia group was negatively correlated with age (4 mm: β = -0.071, P = 0.003; 6 mm: β = -0.162, P < 0.001). Conclusions After SMILE, the CV, Km, and CTSP showed dynamic changes in the early stage, which stabilized after 3 months. Compared to the moderate myopia group, the high myopia group experienced slower corneal stabilization. The change in PTI at 6 months after SMILE may be related to higher preoperative refraction, thinner CCT and younger age.https://doi.org/10.1186/s12886-023-03148-0SMILEModerate myopiaHigh myopiaCorneal remodelingPTI |
| spellingShingle | Yuanpeng Wu Ting Shen Lingtong Tan Ting He Qingqing Zheng Chaoyang Hong Corneal remodeling after SMILE for moderate and high myopia: short-term assessment of spatial changes in corneal volume and thickness BMC Ophthalmology SMILE Moderate myopia High myopia Corneal remodeling PTI |
| title | Corneal remodeling after SMILE for moderate and high myopia: short-term assessment of spatial changes in corneal volume and thickness |
| title_full | Corneal remodeling after SMILE for moderate and high myopia: short-term assessment of spatial changes in corneal volume and thickness |
| title_fullStr | Corneal remodeling after SMILE for moderate and high myopia: short-term assessment of spatial changes in corneal volume and thickness |
| title_full_unstemmed | Corneal remodeling after SMILE for moderate and high myopia: short-term assessment of spatial changes in corneal volume and thickness |
| title_short | Corneal remodeling after SMILE for moderate and high myopia: short-term assessment of spatial changes in corneal volume and thickness |
| title_sort | corneal remodeling after smile for moderate and high myopia short term assessment of spatial changes in corneal volume and thickness |
| topic | SMILE Moderate myopia High myopia Corneal remodeling PTI |
| url | https://doi.org/10.1186/s12886-023-03148-0 |
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