Follow-up for 3 years of a pediatric population diagnosed in 2018 with mother-to-child transmission of HIV in 8 Latin American countries in the PLANTAIDS cohort
Abstract Introduction The frequency of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) in Latin America has decreased considerably. However, new infections continue to be recorded, and the pediatric population remains one of the most vulnerable groups in this region. The ma...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-024-09091-9 |
| _version_ | 1827328440388288512 |
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| author | Beatriz Álvarez Vallejo Alicia Hernanz Lobo Itzíar Carrasco García Tomás Bruno Pérez Greta Mino-Leon Judith Rosabel Soffe Pazmiño Julio Werner Juarez Lorenzana Tatiana Drummond Noris Marlene del Socorro Pavía Ruz María del Rocío Muñoz Hernández Dulce María Morales Pérez Dora Estripeaut Kathia Luciani Karen Sobeida Erazo Martínez Luis Guillermo Castaneda Villatoro Oscar Porras Madrigal Gabriela Ivankovich-Escoto Luis Manuel Prieto Tato María Luisa Navarro Gómez on behalf of the PLANTAIDS network |
| author_facet | Beatriz Álvarez Vallejo Alicia Hernanz Lobo Itzíar Carrasco García Tomás Bruno Pérez Greta Mino-Leon Judith Rosabel Soffe Pazmiño Julio Werner Juarez Lorenzana Tatiana Drummond Noris Marlene del Socorro Pavía Ruz María del Rocío Muñoz Hernández Dulce María Morales Pérez Dora Estripeaut Kathia Luciani Karen Sobeida Erazo Martínez Luis Guillermo Castaneda Villatoro Oscar Porras Madrigal Gabriela Ivankovich-Escoto Luis Manuel Prieto Tato María Luisa Navarro Gómez on behalf of the PLANTAIDS network |
| author_sort | Beatriz Álvarez Vallejo |
| collection | DOAJ |
| description | Abstract Introduction The frequency of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) in Latin America has decreased considerably. However, new infections continue to be recorded, and the pediatric population remains one of the most vulnerable groups in this region. The main objective of the study was to describe the clinical, epidemiological and psychosocial characteristics of new diagnoses of HIV MTCT in 2018 in the PLANTAIDS network (Paediatric Network for Prevention, Early Detection and Treatment of HIV in Children) during the 3 years following diagnosis. Methodology Retrospective, multicenter, descriptive study based on a 3-year follow-up of patients diagnosed with HIV infection due to MTCT in 2018 in 10 hospitals in 8 Latin American countries (Costa Rica, Ecuador, Mexico, Honduras, El Salvador, Panama, Guatemala and Venezuela). The hospitals belonged to the PLANTAIDS network, which is included in CYTED (Ibero-American Programme of Science and Technology for Development). Results The study population comprised 72 pediatric patients (38.9% male). The median age at diagnosis was 2.4 years (IQR: 0.8–5.4). There were 35 cases of opportunistic infections corresponding to 25 patients (34.7%), with tuberculosis being the most common. Adequate childhood vaccination coverage was achieved in 80.5%. There were 3 cases of acute SARS-CoV-2 infection, and these were asymptomatic or mildly symptomatic. According to the Centers for Disease Control and Prevention (CDC) classification, the most frequent clinical-immunological stage at all check-ups was C1. Three patients died from opportunistic infections and/or advanced HIV infection. Conclusions It is important to diagnose HIV infection early in pediatrics, since early initiation of ART is associated with a decrease in mortality. Despite this, HIV infection has a poor prognosis in children, necessitating adequate follow-up to ensure adherence to health care and ART, although it can sometimes prove difficult in children. |
| first_indexed | 2024-03-07T15:17:58Z |
| format | Article |
| id | doaj.art-50fac26bb8c94b30bc6fdf55d44fb841 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-07T15:17:58Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-50fac26bb8c94b30bc6fdf55d44fb8412024-03-05T17:48:32ZengBMCBMC Infectious Diseases1471-23342024-02-0124111210.1186/s12879-024-09091-9Follow-up for 3 years of a pediatric population diagnosed in 2018 with mother-to-child transmission of HIV in 8 Latin American countries in the PLANTAIDS cohortBeatriz Álvarez Vallejo0Alicia Hernanz Lobo1Itzíar Carrasco García2Tomás Bruno Pérez3Greta Mino-Leon4Judith Rosabel Soffe Pazmiño5Julio Werner Juarez Lorenzana6Tatiana Drummond7Noris Marlene del Socorro Pavía Ruz8María del Rocío Muñoz Hernández9Dulce María Morales Pérez10Dora Estripeaut11Kathia Luciani12Karen Sobeida Erazo Martínez13Luis Guillermo Castaneda Villatoro14Oscar Porras Madrigal15Gabriela Ivankovich-Escoto16Luis Manuel Prieto Tato17María Luisa Navarro Gómez18on behalf of the PLANTAIDS networkPediatric Infectious Diseases Department. Hospital Clínico, Universitario Virgen de La ArrixacaPediatric Infectious Diseases Department, Gregorio Marañón University HospitalGregorio Marañón Research Health Institute (IiSGM)Internal Medicine Department, Hospital Universitario Santa LucíaInfectious Diseases Service. Hospital del Niño Dr, Francisco de Icaza BustamanteInfectious Diseases Service. Hospital del Niño Dr, Francisco de Icaza BustamanteUnidad de Atención Integral del VIH e Infecciones Crónicas. Hospital RooseveltPediatric Infectious Disease Service. Department of Paediatrics, Hospital Universitario de CaracasPaediatric HIV/AIDS Clinic, UNAM/HGM, Facultad de Medicina, Universidad Nacional Autónoma de MéxicoPaediatric HIV/AIDS Clinic, UNAM/HGM, Facultad de Medicina, Universidad Nacional Autónoma de MéxicoPediatric Infectious Diseases Department, CLINDI, Hospital Infantil de México Federico GómezPediatric Infectious Disease Service, Hospital del Niño Dr. José Renán EsquivelPediatric Infectious Disease Service, Hospital de Especialidades Pediátricas Omar Torrijos HerreraDepartment of Paediatrics., Hospital Dr Mario Catarino RivasPediatric HIV/AIDS Clinic, Hospital Nacional de Niños Benjamín BloomDepartment of Paediatrics, Hospital Nacional de Niños Dr. Carlos Sáenz HerreraDepartment of Paediatrics, Hospital Nacional de Niños Dr. Carlos Sáenz HerreraDepartment of Paediatrics, Hospital Doce de OctubrePediatric Infectious Diseases Department, Gregorio Marañón University HospitalAbstract Introduction The frequency of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) in Latin America has decreased considerably. However, new infections continue to be recorded, and the pediatric population remains one of the most vulnerable groups in this region. The main objective of the study was to describe the clinical, epidemiological and psychosocial characteristics of new diagnoses of HIV MTCT in 2018 in the PLANTAIDS network (Paediatric Network for Prevention, Early Detection and Treatment of HIV in Children) during the 3 years following diagnosis. Methodology Retrospective, multicenter, descriptive study based on a 3-year follow-up of patients diagnosed with HIV infection due to MTCT in 2018 in 10 hospitals in 8 Latin American countries (Costa Rica, Ecuador, Mexico, Honduras, El Salvador, Panama, Guatemala and Venezuela). The hospitals belonged to the PLANTAIDS network, which is included in CYTED (Ibero-American Programme of Science and Technology for Development). Results The study population comprised 72 pediatric patients (38.9% male). The median age at diagnosis was 2.4 years (IQR: 0.8–5.4). There were 35 cases of opportunistic infections corresponding to 25 patients (34.7%), with tuberculosis being the most common. Adequate childhood vaccination coverage was achieved in 80.5%. There were 3 cases of acute SARS-CoV-2 infection, and these were asymptomatic or mildly symptomatic. According to the Centers for Disease Control and Prevention (CDC) classification, the most frequent clinical-immunological stage at all check-ups was C1. Three patients died from opportunistic infections and/or advanced HIV infection. Conclusions It is important to diagnose HIV infection early in pediatrics, since early initiation of ART is associated with a decrease in mortality. Despite this, HIV infection has a poor prognosis in children, necessitating adequate follow-up to ensure adherence to health care and ART, although it can sometimes prove difficult in children.https://doi.org/10.1186/s12879-024-09091-9HIV/AIDSChildrenMother‐to‐child transmissionSARS-CoV-2 infection |
| spellingShingle | Beatriz Álvarez Vallejo Alicia Hernanz Lobo Itzíar Carrasco García Tomás Bruno Pérez Greta Mino-Leon Judith Rosabel Soffe Pazmiño Julio Werner Juarez Lorenzana Tatiana Drummond Noris Marlene del Socorro Pavía Ruz María del Rocío Muñoz Hernández Dulce María Morales Pérez Dora Estripeaut Kathia Luciani Karen Sobeida Erazo Martínez Luis Guillermo Castaneda Villatoro Oscar Porras Madrigal Gabriela Ivankovich-Escoto Luis Manuel Prieto Tato María Luisa Navarro Gómez on behalf of the PLANTAIDS network Follow-up for 3 years of a pediatric population diagnosed in 2018 with mother-to-child transmission of HIV in 8 Latin American countries in the PLANTAIDS cohort BMC Infectious Diseases HIV/AIDS Children Mother‐to‐child transmission SARS-CoV-2 infection |
| title | Follow-up for 3 years of a pediatric population diagnosed in 2018 with mother-to-child transmission of HIV in 8 Latin American countries in the PLANTAIDS cohort |
| title_full | Follow-up for 3 years of a pediatric population diagnosed in 2018 with mother-to-child transmission of HIV in 8 Latin American countries in the PLANTAIDS cohort |
| title_fullStr | Follow-up for 3 years of a pediatric population diagnosed in 2018 with mother-to-child transmission of HIV in 8 Latin American countries in the PLANTAIDS cohort |
| title_full_unstemmed | Follow-up for 3 years of a pediatric population diagnosed in 2018 with mother-to-child transmission of HIV in 8 Latin American countries in the PLANTAIDS cohort |
| title_short | Follow-up for 3 years of a pediatric population diagnosed in 2018 with mother-to-child transmission of HIV in 8 Latin American countries in the PLANTAIDS cohort |
| title_sort | follow up for 3 years of a pediatric population diagnosed in 2018 with mother to child transmission of hiv in 8 latin american countries in the plantaids cohort |
| topic | HIV/AIDS Children Mother‐to‐child transmission SARS-CoV-2 infection |
| url | https://doi.org/10.1186/s12879-024-09091-9 |
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