Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering
Collagen type I is the main organic constituent of the bone extracellular matrix and has been used for decades as scaffolding material in bone tissue engineering approaches when autografts are not feasible. Polymeric collagen can be easily isolated from various animal sources and can be processed in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/4/599 |
| _version_ | 1797396239604514816 |
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| author | Gustavo A. Rico-Llanos Sara Borrego-González Miguelangel Moncayo-Donoso José Becerra Rick Visser |
| author_facet | Gustavo A. Rico-Llanos Sara Borrego-González Miguelangel Moncayo-Donoso José Becerra Rick Visser |
| author_sort | Gustavo A. Rico-Llanos |
| collection | DOAJ |
| description | Collagen type I is the main organic constituent of the bone extracellular matrix and has been used for decades as scaffolding material in bone tissue engineering approaches when autografts are not feasible. Polymeric collagen can be easily isolated from various animal sources and can be processed in a great number of ways to manufacture biomaterials in the form of sponges, particles, or hydrogels, among others, for different applications. Despite its great biocompatibility and osteoconductivity, collagen type I also has some drawbacks, such as its high biodegradability, low mechanical strength, and lack of osteoinductive activity. Therefore, many attempts have been made to improve the collagen type I-based implants for bone tissue engineering. This review aims to summarize the current status of collagen type I as a biomaterial for bone tissue engineering, as well as to highlight some of the main efforts that have been made recently towards designing and producing collagen implants to improve bone regeneration. |
| first_indexed | 2024-03-09T00:48:30Z |
| format | Article |
| id | doaj.art-50fb23bc411a4624b429294b86190dcb |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T00:48:30Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-50fb23bc411a4624b429294b86190dcb2023-12-11T17:22:57ZengMDPI AGPolymers2073-43602021-02-0113459910.3390/polym13040599Collagen Type I Biomaterials as Scaffolds for Bone Tissue EngineeringGustavo A. Rico-Llanos0Sara Borrego-González1Miguelangel Moncayo-Donoso2José Becerra3Rick Visser4Department of Cell Biology, Genetics and Physiology, Faculty of Science, University of Málaga, IBIMA, 29071 Málaga, SpainAndalusian Center for Nanomedicine and Biotechnology (BIONAND), 29590 Málaga, SpainAndalusian Center for Nanomedicine and Biotechnology (BIONAND), 29590 Málaga, SpainDepartment of Cell Biology, Genetics and Physiology, Faculty of Science, University of Málaga, IBIMA, 29071 Málaga, SpainDepartment of Cell Biology, Genetics and Physiology, Faculty of Science, University of Málaga, IBIMA, 29071 Málaga, SpainCollagen type I is the main organic constituent of the bone extracellular matrix and has been used for decades as scaffolding material in bone tissue engineering approaches when autografts are not feasible. Polymeric collagen can be easily isolated from various animal sources and can be processed in a great number of ways to manufacture biomaterials in the form of sponges, particles, or hydrogels, among others, for different applications. Despite its great biocompatibility and osteoconductivity, collagen type I also has some drawbacks, such as its high biodegradability, low mechanical strength, and lack of osteoinductive activity. Therefore, many attempts have been made to improve the collagen type I-based implants for bone tissue engineering. This review aims to summarize the current status of collagen type I as a biomaterial for bone tissue engineering, as well as to highlight some of the main efforts that have been made recently towards designing and producing collagen implants to improve bone regeneration.https://www.mdpi.com/2073-4360/13/4/599collagenbone tissue engineeringscaffoldsgrowth factorspeptides |
| spellingShingle | Gustavo A. Rico-Llanos Sara Borrego-González Miguelangel Moncayo-Donoso José Becerra Rick Visser Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering Polymers collagen bone tissue engineering scaffolds growth factors peptides |
| title | Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering |
| title_full | Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering |
| title_fullStr | Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering |
| title_full_unstemmed | Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering |
| title_short | Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering |
| title_sort | collagen type i biomaterials as scaffolds for bone tissue engineering |
| topic | collagen bone tissue engineering scaffolds growth factors peptides |
| url | https://www.mdpi.com/2073-4360/13/4/599 |
| work_keys_str_mv | AT gustavoaricollanos collagentypeibiomaterialsasscaffoldsforbonetissueengineering AT saraborregogonzalez collagentypeibiomaterialsasscaffoldsforbonetissueengineering AT miguelangelmoncayodonoso collagentypeibiomaterialsasscaffoldsforbonetissueengineering AT josebecerra collagentypeibiomaterialsasscaffoldsforbonetissueengineering AT rickvisser collagentypeibiomaterialsasscaffoldsforbonetissueengineering |