The dynamics of theta-related pro-active control and response inhibition processes in AD(H)D
Impulsivity and deficits in response inhibition are hallmarks of attention-deficit(-hyperactivity) disorder (AD(H)D), can cause severe problems in daily functioning, and are thus of high clinical relevance. Traditionally, research to elucidate associated neural correlates has intensively, but also q...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221315822100053X |
| _version_ | 1831715446326296576 |
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| author | Nico Adelhöfer Annet Bluschke Veit Roessner Christian Beste |
| author_facet | Nico Adelhöfer Annet Bluschke Veit Roessner Christian Beste |
| author_sort | Nico Adelhöfer |
| collection | DOAJ |
| description | Impulsivity and deficits in response inhibition are hallmarks of attention-deficit(-hyperactivity) disorder (AD(H)D), can cause severe problems in daily functioning, and are thus of high clinical relevance. Traditionally, research to elucidate associated neural correlates has intensively, but also quite selectively examined mechanisms during response inhibition in various tasks. Doing so, in-between trial periods or periods prior to the response inhibition process, where no information relevant to inhibitory control is presented, have been neglected. Yet, these periods may nevertheless reveal relevant information. In the present study, using a case-control cross-sectional design, we take a more holistic approach, examining the inter-relation of pre-trial and within-trial periods in a Go/Nogo task with a focus on EEG theta band activity. Applying EEG beamforming methods, we show that the dynamics between pre-trial (pro-active) and within-trial (inhibition-related) control processes significantly differ between AD(H)D subtypes. We show that response inhibition, and differences between AD(H)D subtypes, exhibit distinct patterns of (at least) three factors: (i) strength of pre-trial (pro-active control) theta-band activity, (ii) the inter-relation of pro-active control and inhibition-relation theta band activity and (iii) the functional neuroanatomical region active during theta-related pro-active control processes. This multi-factorial pattern is captured by AD(H)D subtype clinical symptom clusters. The study provides a first hint that novel cognitive-neurophysiological facets of AD(H)D may be relevant to distinguish AD(H)D subtypes. |
| first_indexed | 2024-12-21T00:18:49Z |
| format | Article |
| id | doaj.art-50fba1b366384aaf9176a30471b743b1 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-21T00:18:49Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-50fba1b366384aaf9176a30471b743b12022-12-21T19:22:09ZengElsevierNeuroImage: Clinical2213-15822021-01-0130102609The dynamics of theta-related pro-active control and response inhibition processes in AD(H)DNico Adelhöfer0Annet Bluschke1Veit Roessner2Christian Beste3Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, GermanyCognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, GermanyCognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, GermanyCorresponding author at: Cognitive Neurophysiology, Faculty of Medicine Carl Gustav Carus, TU Dresden, Department of Child and Adolescent Psychiatry, Fetscherstrasse 74, 01307 Dresden, Germany.; Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, GermanyImpulsivity and deficits in response inhibition are hallmarks of attention-deficit(-hyperactivity) disorder (AD(H)D), can cause severe problems in daily functioning, and are thus of high clinical relevance. Traditionally, research to elucidate associated neural correlates has intensively, but also quite selectively examined mechanisms during response inhibition in various tasks. Doing so, in-between trial periods or periods prior to the response inhibition process, where no information relevant to inhibitory control is presented, have been neglected. Yet, these periods may nevertheless reveal relevant information. In the present study, using a case-control cross-sectional design, we take a more holistic approach, examining the inter-relation of pre-trial and within-trial periods in a Go/Nogo task with a focus on EEG theta band activity. Applying EEG beamforming methods, we show that the dynamics between pre-trial (pro-active) and within-trial (inhibition-related) control processes significantly differ between AD(H)D subtypes. We show that response inhibition, and differences between AD(H)D subtypes, exhibit distinct patterns of (at least) three factors: (i) strength of pre-trial (pro-active control) theta-band activity, (ii) the inter-relation of pro-active control and inhibition-relation theta band activity and (iii) the functional neuroanatomical region active during theta-related pro-active control processes. This multi-factorial pattern is captured by AD(H)D subtype clinical symptom clusters. The study provides a first hint that novel cognitive-neurophysiological facets of AD(H)D may be relevant to distinguish AD(H)D subtypes.http://www.sciencedirect.com/science/article/pii/S221315822100053XAttention deficit hyperactivity disorderEEGThetaResponse inhibitionCognitive control |
| spellingShingle | Nico Adelhöfer Annet Bluschke Veit Roessner Christian Beste The dynamics of theta-related pro-active control and response inhibition processes in AD(H)D NeuroImage: Clinical Attention deficit hyperactivity disorder EEG Theta Response inhibition Cognitive control |
| title | The dynamics of theta-related pro-active control and response inhibition processes in AD(H)D |
| title_full | The dynamics of theta-related pro-active control and response inhibition processes in AD(H)D |
| title_fullStr | The dynamics of theta-related pro-active control and response inhibition processes in AD(H)D |
| title_full_unstemmed | The dynamics of theta-related pro-active control and response inhibition processes in AD(H)D |
| title_short | The dynamics of theta-related pro-active control and response inhibition processes in AD(H)D |
| title_sort | dynamics of theta related pro active control and response inhibition processes in ad h d |
| topic | Attention deficit hyperactivity disorder EEG Theta Response inhibition Cognitive control |
| url | http://www.sciencedirect.com/science/article/pii/S221315822100053X |
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