Thyroid Function and Anti-TPO Antibody Status among Tribal Perimenopausal Women Near Bengaluru, Karnataka, India
Introduction: Higher prevalence of thyroid diseases are noted with increasing age. Symptoms of thyroid disorders often develop so insidiously, that they go unnoticed and there is also the risk of being misinterpreted for menopausal symptoms. Present study was executed in view of paucity of data...
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JCDR Research and Publications Private Limited
2020-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/14163/44793_CE[Ra1]_F(SL)_PF1(AG_KM)_PFA(KM)_PB(AG_KM)_PN(SL).pdf |
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| author | KS Manjula R Reena Swapna Jaswanth SMR Usha |
| author_facet | KS Manjula R Reena Swapna Jaswanth SMR Usha |
| author_sort | KS Manjula |
| collection | DOAJ |
| description | Introduction: Higher prevalence of thyroid diseases are noted
with increasing age. Symptoms of thyroid disorders often
develop so insidiously, that they go unnoticed and there is also
the risk of being misinterpreted for menopausal symptoms.
Present study was executed in view of paucity of data regarding
thyroid disorders among tribal perimenopausal age group and
there was a need for timely intervention of this chronic noncommunicable disorder among these women.
Aim: To determine the thyroid function and anti-Thyroid
Peroxidase Antibody (anti-TPO Ab) status among the tribal
perimenopausal women.
Materials and Methods: A descriptive, cross-sectional
study was conducted for a period of six months from July
2017 to December 2017 among perimenopausal women in
the age group of 40-55 years residing at Hakki Pikki Tribal
Colony near Bengaluru, Karnataka, India. Thyroid Stimulating
Hormone (TSH), Total T3
(Total Tri iodothyronine), Total T4
(Total Tetraidiodothyronine) and anti-TPO antibody levels were
estimated by Chemiluminescence Immuno Assay (CLIA). Data
was analysed using Open Epi software to find out Mean±SD,
p-value (Student’s t-test with significance set at p<0.05) and
r-value (Pearson’s correlation coefficient).
Results: Subclinical Hypothyroidism (SCH) was observed in
3 (7.32%) women and anti-TPO Ab positivity (anti-TPO antibody
level >30 IU/mL) was found in 14 (34.14%) women amongst
41 perimenopausal subjects. Raised anti-TPO Ab was observed
in all the 3 (100%) SCH women and 11 (26.82%) euthyroid
women. Significant difference (p<0.001) between anti-TPO
Ab values among SCH and euthyroid women with significant
positive correlation (r-value 0.7023 and p<0.05) between TSH
and anti-TPO Ab values in anti-TPO Ab positive women was
noted.
Conclusion: Anti-TPO Ab positivity was seen in 34% of
perimenopausal women, out of them majority 79% was in
euthyroid state and 21% had SCH. Hence in addition to routine
thyroid profile, we suggest estimation of anti-TPO Ab levels in
this age group. |
| first_indexed | 2024-12-21T21:43:54Z |
| format | Article |
| id | doaj.art-50fcaff6119c4e46b0ee0a8375ab4b14 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-21T21:43:54Z |
| publishDate | 2020-10-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-50fcaff6119c4e46b0ee0a8375ab4b142022-12-21T18:49:18ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2020-10-011410BC28BC3210.7860/JCDR/2020/44793.14163Thyroid Function and Anti-TPO Antibody Status among Tribal Perimenopausal Women Near Bengaluru, Karnataka, IndiaKS Manjula0R Reena1Swapna Jaswanth2SMR Usha3Associate Professor, Department of Biochemistry, Rajarajeswari Medical College and Hospital, Bengaluru, Karnataka, India.Associate Professor, Department of Biochemistry, Rajarajeswari Medical College and Hospital, Bengaluru, Karnataka, India.Associate Professor, Department of Community Medicine, Rajarajeswari Medical College and Hospital, Bengaluru, Karnataka, India.Professor and Head, Department of Biochemistry, Rajarajeswari Medical College and Hospital, Bengaluru, Karnataka, India.Introduction: Higher prevalence of thyroid diseases are noted with increasing age. Symptoms of thyroid disorders often develop so insidiously, that they go unnoticed and there is also the risk of being misinterpreted for menopausal symptoms. Present study was executed in view of paucity of data regarding thyroid disorders among tribal perimenopausal age group and there was a need for timely intervention of this chronic noncommunicable disorder among these women. Aim: To determine the thyroid function and anti-Thyroid Peroxidase Antibody (anti-TPO Ab) status among the tribal perimenopausal women. Materials and Methods: A descriptive, cross-sectional study was conducted for a period of six months from July 2017 to December 2017 among perimenopausal women in the age group of 40-55 years residing at Hakki Pikki Tribal Colony near Bengaluru, Karnataka, India. Thyroid Stimulating Hormone (TSH), Total T3 (Total Tri iodothyronine), Total T4 (Total Tetraidiodothyronine) and anti-TPO antibody levels were estimated by Chemiluminescence Immuno Assay (CLIA). Data was analysed using Open Epi software to find out Mean±SD, p-value (Student’s t-test with significance set at p<0.05) and r-value (Pearson’s correlation coefficient). Results: Subclinical Hypothyroidism (SCH) was observed in 3 (7.32%) women and anti-TPO Ab positivity (anti-TPO antibody level >30 IU/mL) was found in 14 (34.14%) women amongst 41 perimenopausal subjects. Raised anti-TPO Ab was observed in all the 3 (100%) SCH women and 11 (26.82%) euthyroid women. Significant difference (p<0.001) between anti-TPO Ab values among SCH and euthyroid women with significant positive correlation (r-value 0.7023 and p<0.05) between TSH and anti-TPO Ab values in anti-TPO Ab positive women was noted. Conclusion: Anti-TPO Ab positivity was seen in 34% of perimenopausal women, out of them majority 79% was in euthyroid state and 21% had SCH. Hence in addition to routine thyroid profile, we suggest estimation of anti-TPO Ab levels in this age group.https://jcdr.net/articles/PDF/14163/44793_CE[Ra1]_F(SL)_PF1(AG_KM)_PFA(KM)_PB(AG_KM)_PN(SL).pdfanti-thyroid peroxidase antibodyhakki pikki tribalperimenopausethyroid diseasesthyroid function tests |
| spellingShingle | KS Manjula R Reena Swapna Jaswanth SMR Usha Thyroid Function and Anti-TPO Antibody Status among Tribal Perimenopausal Women Near Bengaluru, Karnataka, India Journal of Clinical and Diagnostic Research anti-thyroid peroxidase antibody hakki pikki tribal perimenopause thyroid diseases thyroid function tests |
| title | Thyroid Function and Anti-TPO Antibody Status among Tribal Perimenopausal Women Near Bengaluru, Karnataka, India |
| title_full | Thyroid Function and Anti-TPO Antibody Status among Tribal Perimenopausal Women Near Bengaluru, Karnataka, India |
| title_fullStr | Thyroid Function and Anti-TPO Antibody Status among Tribal Perimenopausal Women Near Bengaluru, Karnataka, India |
| title_full_unstemmed | Thyroid Function and Anti-TPO Antibody Status among Tribal Perimenopausal Women Near Bengaluru, Karnataka, India |
| title_short | Thyroid Function and Anti-TPO Antibody Status among Tribal Perimenopausal Women Near Bengaluru, Karnataka, India |
| title_sort | thyroid function and anti tpo antibody status among tribal perimenopausal women near bengaluru karnataka india |
| topic | anti-thyroid peroxidase antibody hakki pikki tribal perimenopause thyroid diseases thyroid function tests |
| url | https://jcdr.net/articles/PDF/14163/44793_CE[Ra1]_F(SL)_PF1(AG_KM)_PFA(KM)_PB(AG_KM)_PN(SL).pdf |
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