Comparison of Ultrasonography and CT for Determining the Preoperative Benign or Malignant Nature of Thyroid Nodules: Diagnostic Performance According to Calcification
Background: The present study was designed to investigate the presence or absence of calcification and whether calcification size affect the diagnostic accuracy of ultrasonography (US) and computed tomography (CT) in predicting the benign or malignant nature of thyroid nodules. Material and Methods:...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-09-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/1533033820948183 |
| _version_ | 1811323816042823680 |
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| author | Jian-Hui Wu MD Wei Zeng MD Ren-Guo Wu MD Mei Wang MD Fei Ye MD Min-Yi Fu MD |
| author_facet | Jian-Hui Wu MD Wei Zeng MD Ren-Guo Wu MD Mei Wang MD Fei Ye MD Min-Yi Fu MD |
| author_sort | Jian-Hui Wu MD |
| collection | DOAJ |
| description | Background: The present study was designed to investigate the presence or absence of calcification and whether calcification size affect the diagnostic accuracy of ultrasonography (US) and computed tomography (CT) in predicting the benign or malignant nature of thyroid nodules. Material and Methods: From May 2014 to April 2019, 445 patients underwent thyroid US and neck CT before thyroid surgery. In each case, US and CT were retrospectively examined by radiologists. We divided the patients into 3 groups according to the type of calcification: no calcification, microcalcification, and macrocalcification. And macrocalcification group divided into rim calcifications and non-rim calcifications groups. We evaluated the diagnostic accuracy of US and CT for differentiating malignant from benign thyroid nodules using histopathological results as a reference standard. Results: In the overall population, adding CT to US resulted in greater sensitivity, lower specificity, and lower accuracy in the prediction of the benign or malignant nature of nodules. In the group with no calcification, US had a significantly greater accuracy than CT and combined US/CT. In the group with macrocalcification, especially in rim calcifications, adding CT to US resulted in greater sensitivity than US, and CT exhibited greater sensitivity and accuracy than US. Conclusion: US is superior to CT for the prediction of the benign or malignant nature of nodules in thyroid lesions according to calcification and CT is also currently not recommended as a routine imaging tool for thyroid nodules. However, the superior sensitivity and accuracy of CT in lesions with macrocalcification especially in rim calcifications may enable CT to play a complementary role in identifying benign and malignant nodules. |
| first_indexed | 2024-04-13T14:03:09Z |
| format | Article |
| id | doaj.art-50fd024fed234406a6223e7554d6128a |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-04-13T14:03:09Z |
| publishDate | 2020-09-01 |
| publisher | SAGE Publishing |
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| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-50fd024fed234406a6223e7554d6128a2022-12-22T02:44:00ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382020-09-011910.1177/1533033820948183Comparison of Ultrasonography and CT for Determining the Preoperative Benign or Malignant Nature of Thyroid Nodules: Diagnostic Performance According to CalcificationJian-Hui Wu MD0Wei Zeng MD1Ren-Guo Wu MD2Mei Wang MD3Fei Ye MD4Min-Yi Fu MD5 The Department of Otolaryngology in the Zhongshan City People’s Hospital, Zhongshan Affiliated Hospital of Sun Yat–sen University, Zhongshan, Guangdong, People’s Republic of China The Department of Otolaryngology in the Zhongshan City People’s Hospital, Zhongshan Affiliated Hospital of Sun Yat–sen University, Zhongshan, Guangdong, People’s Republic of China The Department of Radiology in the Zhongshan City People’s Hospital, Zhongshan Affiliated Hospital of Sun Yat–sen University, Zhongshan, Guangdong, People’s Republic of China The Department of Ultrasonography Image in the Zhongshan City People’s Hospital, Zhongshan Affiliated Hospital of Sun Yat–sen University, Zhongshan, Guangdong, People’s Republic of China The Department of Otolaryngology in the Zhongshan City People’s Hospital, Zhongshan Affiliated Hospital of Sun Yat–sen University, Zhongshan, Guangdong, People’s Republic of China The Department of Otolaryngology in the Zhongshan City People’s Hospital, Zhongshan Affiliated Hospital of Sun Yat–sen University, Zhongshan, Guangdong, People’s Republic of ChinaBackground: The present study was designed to investigate the presence or absence of calcification and whether calcification size affect the diagnostic accuracy of ultrasonography (US) and computed tomography (CT) in predicting the benign or malignant nature of thyroid nodules. Material and Methods: From May 2014 to April 2019, 445 patients underwent thyroid US and neck CT before thyroid surgery. In each case, US and CT were retrospectively examined by radiologists. We divided the patients into 3 groups according to the type of calcification: no calcification, microcalcification, and macrocalcification. And macrocalcification group divided into rim calcifications and non-rim calcifications groups. We evaluated the diagnostic accuracy of US and CT for differentiating malignant from benign thyroid nodules using histopathological results as a reference standard. Results: In the overall population, adding CT to US resulted in greater sensitivity, lower specificity, and lower accuracy in the prediction of the benign or malignant nature of nodules. In the group with no calcification, US had a significantly greater accuracy than CT and combined US/CT. In the group with macrocalcification, especially in rim calcifications, adding CT to US resulted in greater sensitivity than US, and CT exhibited greater sensitivity and accuracy than US. Conclusion: US is superior to CT for the prediction of the benign or malignant nature of nodules in thyroid lesions according to calcification and CT is also currently not recommended as a routine imaging tool for thyroid nodules. However, the superior sensitivity and accuracy of CT in lesions with macrocalcification especially in rim calcifications may enable CT to play a complementary role in identifying benign and malignant nodules.https://doi.org/10.1177/1533033820948183 |
| spellingShingle | Jian-Hui Wu MD Wei Zeng MD Ren-Guo Wu MD Mei Wang MD Fei Ye MD Min-Yi Fu MD Comparison of Ultrasonography and CT for Determining the Preoperative Benign or Malignant Nature of Thyroid Nodules: Diagnostic Performance According to Calcification Technology in Cancer Research & Treatment |
| title | Comparison of Ultrasonography and CT for Determining the Preoperative Benign or Malignant Nature of Thyroid Nodules: Diagnostic Performance According to Calcification |
| title_full | Comparison of Ultrasonography and CT for Determining the Preoperative Benign or Malignant Nature of Thyroid Nodules: Diagnostic Performance According to Calcification |
| title_fullStr | Comparison of Ultrasonography and CT for Determining the Preoperative Benign or Malignant Nature of Thyroid Nodules: Diagnostic Performance According to Calcification |
| title_full_unstemmed | Comparison of Ultrasonography and CT for Determining the Preoperative Benign or Malignant Nature of Thyroid Nodules: Diagnostic Performance According to Calcification |
| title_short | Comparison of Ultrasonography and CT for Determining the Preoperative Benign or Malignant Nature of Thyroid Nodules: Diagnostic Performance According to Calcification |
| title_sort | comparison of ultrasonography and ct for determining the preoperative benign or malignant nature of thyroid nodules diagnostic performance according to calcification |
| url | https://doi.org/10.1177/1533033820948183 |
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