Exercise-Induced Wheezing among Japanese Pre-School Children and Pupils
Background: Exercise-induced wheezing (EIW) may be a symptom of asthma and is a predictor of exercise- induced bronchoconstriction, transient narrowing of the lower airway following exercise in the presence or absence of diagnosed asthma. Population-based studies with a large sample of EIW in relati...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-01-01
|
| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015300393 |
| _version_ | 1818310382597439488 |
|---|---|
| author | Yoko Murakami Satoshi Honjo Hiroshi Odajima Yuichi Adachi Koichi Yoshida Yukihiro Ohya Akira Akasawa |
| author_facet | Yoko Murakami Satoshi Honjo Hiroshi Odajima Yuichi Adachi Koichi Yoshida Yukihiro Ohya Akira Akasawa |
| author_sort | Yoko Murakami |
| collection | DOAJ |
| description | Background: Exercise-induced wheezing (EIW) may be a symptom of asthma and is a predictor of exercise- induced bronchoconstriction, transient narrowing of the lower airway following exercise in the presence or absence of diagnosed asthma. Population-based studies with a large sample of EIW in relation to age, sex, current asthma severity and medication usage have been sparse.
Methods: International Study of Asthma and Allergies in Childhood questionnaires were distributed at 885 nurseries, 535 primary schools, 321 junior high schools and 190 high schools, respectively, across Japan, and the corresponding data on 46,597, 41,216, 45,960 and 51,104 children were analyzed.
Results: Prevalence of EIW was 4.8, 4.7, 17.9 and 15.4% for each of the four educational facility types, respectively. Among 24,103 current asthmatics, 20.9, 28.7, 76.1 and 73.6% of subjects for the 4 educational facility groups reported to have experienced EIW, respectively. Severity of current asthma was associated with the risk of EIW; odds ratio (95% confidence interval) of children with asthma attack every day for having EIW once a week or more, using intermittent asthmatics as reference group, were 24.48 (19.33 to 31.01) adjusted for other covariates. Among current asthmatic kindergartners, increase in risk for EIW due to ascending severity of current asthma was mitigated by daily use of leukotriene receptor antagonist (p for interaction=0.071).
Conclusions: EIW was not rare among current asthmatic children. An increased risk for EIW was in accordance with increasing severity of current asthma and this relation was mitigated with leukotriene receptor antagonist daily use among kindergartners. |
| first_indexed | 2024-12-13T07:45:11Z |
| format | Article |
| id | doaj.art-50fef157b1a742bd8e36dc9c1f9ccc9f |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-13T07:45:11Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-50fef157b1a742bd8e36dc9c1f9ccc9f2022-12-21T23:54:51ZengElsevierAllergology International1323-89302014-01-0163225125910.2332/allergolint.13-OA-0644Exercise-Induced Wheezing among Japanese Pre-School Children and PupilsYoko Murakami0Satoshi Honjo1Hiroshi Odajima2Yuichi Adachi3Koichi Yoshida4Yukihiro Ohya5Akira Akasawa6Department of Paediatrics, National Hospital Organization Fukuoka National Hospital, FukuokaDepartment of Paediatrics, National Hospital Organization Fukuoka National Hospital, FukuokaDepartment of Paediatrics, National Hospital Organization Fukuoka National Hospital, FukuokaDepartment of Paediatrics, Faculty of Medicine, Graduate School of Medicine and Pharmaceutical Science for Education, Toyama University, ToyamaDivision of Allergy, Tokyo Metropolitan Children's Medical CentreDivision of Allergy, National Centre for Child Health and Development, Tokyo, JapanDivision of Allergy, Tokyo Metropolitan Children's Medical CentreBackground: Exercise-induced wheezing (EIW) may be a symptom of asthma and is a predictor of exercise- induced bronchoconstriction, transient narrowing of the lower airway following exercise in the presence or absence of diagnosed asthma. Population-based studies with a large sample of EIW in relation to age, sex, current asthma severity and medication usage have been sparse. Methods: International Study of Asthma and Allergies in Childhood questionnaires were distributed at 885 nurseries, 535 primary schools, 321 junior high schools and 190 high schools, respectively, across Japan, and the corresponding data on 46,597, 41,216, 45,960 and 51,104 children were analyzed. Results: Prevalence of EIW was 4.8, 4.7, 17.9 and 15.4% for each of the four educational facility types, respectively. Among 24,103 current asthmatics, 20.9, 28.7, 76.1 and 73.6% of subjects for the 4 educational facility groups reported to have experienced EIW, respectively. Severity of current asthma was associated with the risk of EIW; odds ratio (95% confidence interval) of children with asthma attack every day for having EIW once a week or more, using intermittent asthmatics as reference group, were 24.48 (19.33 to 31.01) adjusted for other covariates. Among current asthmatic kindergartners, increase in risk for EIW due to ascending severity of current asthma was mitigated by daily use of leukotriene receptor antagonist (p for interaction=0.071). Conclusions: EIW was not rare among current asthmatic children. An increased risk for EIW was in accordance with increasing severity of current asthma and this relation was mitigated with leukotriene receptor antagonist daily use among kindergartners.http://www.sciencedirect.com/science/article/pii/S1323893015300393bronchial asthmachildhood asthmainhaled steroidleukotriene receptor antagonistwheeze |
| spellingShingle | Yoko Murakami Satoshi Honjo Hiroshi Odajima Yuichi Adachi Koichi Yoshida Yukihiro Ohya Akira Akasawa Exercise-Induced Wheezing among Japanese Pre-School Children and Pupils Allergology International bronchial asthma childhood asthma inhaled steroid leukotriene receptor antagonist wheeze |
| title | Exercise-Induced Wheezing among Japanese Pre-School Children and Pupils |
| title_full | Exercise-Induced Wheezing among Japanese Pre-School Children and Pupils |
| title_fullStr | Exercise-Induced Wheezing among Japanese Pre-School Children and Pupils |
| title_full_unstemmed | Exercise-Induced Wheezing among Japanese Pre-School Children and Pupils |
| title_short | Exercise-Induced Wheezing among Japanese Pre-School Children and Pupils |
| title_sort | exercise induced wheezing among japanese pre school children and pupils |
| topic | bronchial asthma childhood asthma inhaled steroid leukotriene receptor antagonist wheeze |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015300393 |
| work_keys_str_mv | AT yokomurakami exerciseinducedwheezingamongjapanesepreschoolchildrenandpupils AT satoshihonjo exerciseinducedwheezingamongjapanesepreschoolchildrenandpupils AT hiroshiodajima exerciseinducedwheezingamongjapanesepreschoolchildrenandpupils AT yuichiadachi exerciseinducedwheezingamongjapanesepreschoolchildrenandpupils AT koichiyoshida exerciseinducedwheezingamongjapanesepreschoolchildrenandpupils AT yukihiroohya exerciseinducedwheezingamongjapanesepreschoolchildrenandpupils AT akiraakasawa exerciseinducedwheezingamongjapanesepreschoolchildrenandpupils |