The glutathione S-transferase P1 341C>T polymorphism and cancer risk: a meta-analysis of 28 case-control studies.
BACKGROUND: GSTP1, which is one major group of the glutathione S-transferase family, plays an important role in the metabolism of carcinogens and toxins, reducing damage of DNA as a suppressor of carcinogenesis. The 341C>T polymorphism of the GSTP1 has been implicated in cancer risk through cutti...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3578943?pdf=render |
| _version_ | 1818927583644876800 |
|---|---|
| author | Sheng-xin Huang Fei-xiang Wu Min Luo Liang Ma Ke-feng Gao Jian Li Wen-juan Wu Shan Huang Qi Yang Ke Liu Yin-nong Zhao Le-qun Li |
| author_facet | Sheng-xin Huang Fei-xiang Wu Min Luo Liang Ma Ke-feng Gao Jian Li Wen-juan Wu Shan Huang Qi Yang Ke Liu Yin-nong Zhao Le-qun Li |
| author_sort | Sheng-xin Huang |
| collection | DOAJ |
| description | BACKGROUND: GSTP1, which is one major group of the glutathione S-transferase family, plays an important role in the metabolism of carcinogens and toxins, reducing damage of DNA as a suppressor of carcinogenesis. The 341C>T polymorphism of the GSTP1 has been implicated in cancer risk through cutting down its metabolic detoxification activities. However, results from previous studies remain conflicting rather than conclusive. To clarify the correlation and provide more statistical evidence for detecting the significance of 341C>T, a meta-analysis was conducted. METHODOLOGY/PRINCIPAL FINDINGS: The relevant studies were identified through searching of PubMed, Embase, ISI Web of Knowledge and China National Knowledge Infrastructure in August 2012, and selected based on the established inclusion criteria for publications, then a meta-analysis was performed to quantitatively summarize the association of GSTP1 341C>T polymorphism with cancer susceptibility. Stratified analyses were employed to identify the source of heterogeneity. Publication bias was evaluated as well as sensitivity analysis. Based on 28 case-control studies with 13249 cases and 16798 controls, the pooled results indicated that the variant genotypes significantly increased the risk of cancer in homozygote comparison (TT versus CC: P = 0.012, OR = 1.40, 95% CI: 1.08-1.81, P(het.) = 0.575), and recessive model (TT versus CT/CC: P = 0.012, OR = 1.40, 95% CI: 1.08-1.81, P(het.) = 0.562). This was confirmed when stratified analyses were conducted according to ethnicity, source of control, matched control, quality score and cancer types. Moreover, significantly increased risk of cancer was also found in lung cancer (heterozygote comparison and dominant model). The stability of these observations was confirmed by a sensitivity analysis. Begger's funnel plot and Egger's test did not reveal any publication bias. CONCLUSIONS/SIGNIFICANCE: This meta-analysis suggests that the GSTP1 341C>T polymorphism may contribute to genetic susceptibility to cancer, especially to lung cancer, and in Asian population. Nevertheless, additional well-designed studies focusing on different ethnicity and cancer types are needed to provide a more exact and comprehensive conclusion. |
| first_indexed | 2024-12-20T03:15:19Z |
| format | Article |
| id | doaj.art-50ffbe06b5574a22b7637e9f9dd90a2f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T03:15:19Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-50ffbe06b5574a22b7637e9f9dd90a2f2022-12-21T19:55:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5672210.1371/journal.pone.0056722The glutathione S-transferase P1 341C>T polymorphism and cancer risk: a meta-analysis of 28 case-control studies.Sheng-xin HuangFei-xiang WuMin LuoLiang MaKe-feng GaoJian LiWen-juan WuShan HuangQi YangKe LiuYin-nong ZhaoLe-qun LiBACKGROUND: GSTP1, which is one major group of the glutathione S-transferase family, plays an important role in the metabolism of carcinogens and toxins, reducing damage of DNA as a suppressor of carcinogenesis. The 341C>T polymorphism of the GSTP1 has been implicated in cancer risk through cutting down its metabolic detoxification activities. However, results from previous studies remain conflicting rather than conclusive. To clarify the correlation and provide more statistical evidence for detecting the significance of 341C>T, a meta-analysis was conducted. METHODOLOGY/PRINCIPAL FINDINGS: The relevant studies were identified through searching of PubMed, Embase, ISI Web of Knowledge and China National Knowledge Infrastructure in August 2012, and selected based on the established inclusion criteria for publications, then a meta-analysis was performed to quantitatively summarize the association of GSTP1 341C>T polymorphism with cancer susceptibility. Stratified analyses were employed to identify the source of heterogeneity. Publication bias was evaluated as well as sensitivity analysis. Based on 28 case-control studies with 13249 cases and 16798 controls, the pooled results indicated that the variant genotypes significantly increased the risk of cancer in homozygote comparison (TT versus CC: P = 0.012, OR = 1.40, 95% CI: 1.08-1.81, P(het.) = 0.575), and recessive model (TT versus CT/CC: P = 0.012, OR = 1.40, 95% CI: 1.08-1.81, P(het.) = 0.562). This was confirmed when stratified analyses were conducted according to ethnicity, source of control, matched control, quality score and cancer types. Moreover, significantly increased risk of cancer was also found in lung cancer (heterozygote comparison and dominant model). The stability of these observations was confirmed by a sensitivity analysis. Begger's funnel plot and Egger's test did not reveal any publication bias. CONCLUSIONS/SIGNIFICANCE: This meta-analysis suggests that the GSTP1 341C>T polymorphism may contribute to genetic susceptibility to cancer, especially to lung cancer, and in Asian population. Nevertheless, additional well-designed studies focusing on different ethnicity and cancer types are needed to provide a more exact and comprehensive conclusion.http://europepmc.org/articles/PMC3578943?pdf=render |
| spellingShingle | Sheng-xin Huang Fei-xiang Wu Min Luo Liang Ma Ke-feng Gao Jian Li Wen-juan Wu Shan Huang Qi Yang Ke Liu Yin-nong Zhao Le-qun Li The glutathione S-transferase P1 341C>T polymorphism and cancer risk: a meta-analysis of 28 case-control studies. PLoS ONE |
| title | The glutathione S-transferase P1 341C>T polymorphism and cancer risk: a meta-analysis of 28 case-control studies. |
| title_full | The glutathione S-transferase P1 341C>T polymorphism and cancer risk: a meta-analysis of 28 case-control studies. |
| title_fullStr | The glutathione S-transferase P1 341C>T polymorphism and cancer risk: a meta-analysis of 28 case-control studies. |
| title_full_unstemmed | The glutathione S-transferase P1 341C>T polymorphism and cancer risk: a meta-analysis of 28 case-control studies. |
| title_short | The glutathione S-transferase P1 341C>T polymorphism and cancer risk: a meta-analysis of 28 case-control studies. |
| title_sort | glutathione s transferase p1 341c t polymorphism and cancer risk a meta analysis of 28 case control studies |
| url | http://europepmc.org/articles/PMC3578943?pdf=render |
| work_keys_str_mv | AT shengxinhuang theglutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT feixiangwu theglutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT minluo theglutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT liangma theglutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT kefenggao theglutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT jianli theglutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT wenjuanwu theglutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT shanhuang theglutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT qiyang theglutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT keliu theglutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT yinnongzhao theglutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT lequnli theglutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT shengxinhuang glutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT feixiangwu glutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT minluo glutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT liangma glutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT kefenggao glutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT jianli glutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT wenjuanwu glutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT shanhuang glutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT qiyang glutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT keliu glutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT yinnongzhao glutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies AT lequnli glutathionestransferasep1341ctpolymorphismandcancerriskametaanalysisof28casecontrolstudies |