Dysregulation of Microtubule Nucleating Proteins in Cancer Cells
In cells, microtubules typically nucleate from microtubule organizing centers, such as centrosomes. γ-Tubulin, which forms multiprotein complexes, is essential for nucleation. The γ-tubulin ring complex (γ-TuRC) is an efficient microtubule nucleator that requires additional centrosomal proteins for...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/22/5638 |
| _version_ | 1797510931884802048 |
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| author | Pavel Dráber Eduarda Dráberová |
| author_facet | Pavel Dráber Eduarda Dráberová |
| author_sort | Pavel Dráber |
| collection | DOAJ |
| description | In cells, microtubules typically nucleate from microtubule organizing centers, such as centrosomes. γ-Tubulin, which forms multiprotein complexes, is essential for nucleation. The γ-tubulin ring complex (γ-TuRC) is an efficient microtubule nucleator that requires additional centrosomal proteins for its activation and targeting. Evidence suggests that there is a dysfunction of centrosomal microtubule nucleation in cancer cells. Despite decades of molecular analysis of γ-TuRC and its interacting factors, the mechanisms of microtubule nucleation in normal and cancer cells remains obscure. Here, we review recent work on the high-resolution structure of γ-TuRC, which brings new insight into the mechanism of microtubule nucleation. We discuss the effects of γ-TuRC protein dysregulation on cancer cell behavior and new compounds targeting γ-tubulin. Drugs inhibiting γ-TuRC functions could represent an alternative to microtubule targeting agents in cancer chemotherapy. |
| first_indexed | 2024-03-10T05:39:15Z |
| format | Article |
| id | doaj.art-50fffca352f641a596ad3162bdff5745 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T05:39:15Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-50fffca352f641a596ad3162bdff57452023-11-22T22:41:06ZengMDPI AGCancers2072-66942021-11-011322563810.3390/cancers13225638Dysregulation of Microtubule Nucleating Proteins in Cancer CellsPavel Dráber0Eduarda Dráberová1Department of Biology of Cytoskeleton, Institute of Molecular Genetics, Czech Academy of Sciences, CZ-142 20 Prague, Czech RepublicDepartment of Biology of Cytoskeleton, Institute of Molecular Genetics, Czech Academy of Sciences, CZ-142 20 Prague, Czech RepublicIn cells, microtubules typically nucleate from microtubule organizing centers, such as centrosomes. γ-Tubulin, which forms multiprotein complexes, is essential for nucleation. The γ-tubulin ring complex (γ-TuRC) is an efficient microtubule nucleator that requires additional centrosomal proteins for its activation and targeting. Evidence suggests that there is a dysfunction of centrosomal microtubule nucleation in cancer cells. Despite decades of molecular analysis of γ-TuRC and its interacting factors, the mechanisms of microtubule nucleation in normal and cancer cells remains obscure. Here, we review recent work on the high-resolution structure of γ-TuRC, which brings new insight into the mechanism of microtubule nucleation. We discuss the effects of γ-TuRC protein dysregulation on cancer cell behavior and new compounds targeting γ-tubulin. Drugs inhibiting γ-TuRC functions could represent an alternative to microtubule targeting agents in cancer chemotherapy.https://www.mdpi.com/2072-6694/13/22/5638cancersmicrotubule nucleationγ-tubulin complexes |
| spellingShingle | Pavel Dráber Eduarda Dráberová Dysregulation of Microtubule Nucleating Proteins in Cancer Cells Cancers cancers microtubule nucleation γ-tubulin complexes |
| title | Dysregulation of Microtubule Nucleating Proteins in Cancer Cells |
| title_full | Dysregulation of Microtubule Nucleating Proteins in Cancer Cells |
| title_fullStr | Dysregulation of Microtubule Nucleating Proteins in Cancer Cells |
| title_full_unstemmed | Dysregulation of Microtubule Nucleating Proteins in Cancer Cells |
| title_short | Dysregulation of Microtubule Nucleating Proteins in Cancer Cells |
| title_sort | dysregulation of microtubule nucleating proteins in cancer cells |
| topic | cancers microtubule nucleation γ-tubulin complexes |
| url | https://www.mdpi.com/2072-6694/13/22/5638 |
| work_keys_str_mv | AT paveldraber dysregulationofmicrotubulenucleatingproteinsincancercells AT eduardadraberova dysregulationofmicrotubulenucleatingproteinsincancercells |