ClC-2 knockdown prevents cerebrovascular remodeling via inhibition of the Wnt/β-catenin signaling pathway

ClC-2 knockdown prevents cerebrovascular remodeling via inhibition of the Wnt/β-catenin signaling pathway

Abstract Background Mishandling of intracellular chloride (Cl−) concentration ([Cl−]i) in cerebrovascular smooth muscle cells is implicated in several pathological processes, including hyperplasia and remodeling. We investigated the effects of ClC-2-mediated Cl− efflux on the proliferation of human...

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Bibliographic Details
Main Authors: Jingjing Lu, Feng Xu, Yingna Zhang, Hong Lu, Jiewen Zhang
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Cellular & Molecular Biology Letters
Subjects:
Cerebrovascular smooth muscle cells
Proliferation
Angiotensin II
Chloride
ClC-2
Wnt/β-catenin signaling
Online Access:http://link.springer.com/article/10.1186/s11658-018-0095-z

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