Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function.

Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function.

A20 is a negative regulator of NF-κB, and mutational loss of A20 expression is involved in the pathogenesis of autoimmune diseases and B-cell lymphomas. To clarify the role of A20 in adult hematopoiesis, we generated conditional A20 knockout mice (A20(flox/flox) ) and crossed them with Mx-1Cre (MxCr...

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Main Authors: Akiko Nagamachi, Yuichiro Nakata, Takeshi Ueda, Norimasa Yamasaki, Yasuhiro Ebihara, Kohichiro Tsuji, Zen-ichiro Honda, Keiyo Takubo, Toshio Suda, Hideaki Oda, Toshiya Inaba, Hiroaki Honda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3909109?pdf=render

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