Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome

Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome

22q11.2 Deletion Syndrome (22q11DS) is a neurodevelopmental disorder associated with cranial nerve anomalies and disordered oropharyngeal function, including pediatric dysphagia. Using the LgDel 22q11DS mouse model, we investigated whether sensory neuron differentiation in the trigeminal ganglion (C...

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Bibliographic Details
Main Authors: Beverly A. Karpinski, Thomas M. Maynard, Corey A. Bryan, Gelila Yitsege, Anelia Horvath, Norman H. Lee, Sally A. Moody, Anthony-Samuel LaMantia
Format: Article
Language:English
Published: The Company of Biologists 2022-02-01
Series:Disease Models & Mechanisms
Subjects:
22q11 deletion syndrome
cranial places
neural crest
precursor proliferation
sensory neurons
trigeminal ganglion
Online Access:http://dmm.biologists.org/content/15/2/dmm047357

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