The role of m5C methyltransferases in cardiovascular diseases
The global leading cause of death is cardiovascular disease (CVD). Although advances in prevention and treatment have been made, the role of RNA epigenetics in CVD is not fully understood. Studies have found that RNA modifications regulate gene expression in mammalian cells, and m5C (5-methylcytosin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1225014/full |
| _version_ | 1797786698554277888 |
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| author | Yan-Yue Wang Yuan Tian Yong-Zhen Li Yi-Fan Liu Yu-Yan Zhao Lin-Hui Chen Chi Zhang |
| author_facet | Yan-Yue Wang Yuan Tian Yong-Zhen Li Yi-Fan Liu Yu-Yan Zhao Lin-Hui Chen Chi Zhang |
| author_sort | Yan-Yue Wang |
| collection | DOAJ |
| description | The global leading cause of death is cardiovascular disease (CVD). Although advances in prevention and treatment have been made, the role of RNA epigenetics in CVD is not fully understood. Studies have found that RNA modifications regulate gene expression in mammalian cells, and m5C (5-methylcytosine) is a recently discovered RNA modification that plays a role in gene regulation. As a result of these developments, there has been renewed interest in elucidating the nature and function of RNA “epitranscriptomic” modifications. Recent studies on m5C RNA methylomes, their functions, and the proteins that initiate, translate and manipulate this modification are discussed in this review. This review improves the understanding of m5C modifications and their properties, functions, and implications in cardiac pathologies, including cardiomyopathy, heart failure, and atherosclerosis. |
| first_indexed | 2024-03-13T01:11:37Z |
| format | Article |
| id | doaj.art-5102d6af6bc3487891b83db9607cff36 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-13T01:11:37Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-5102d6af6bc3487891b83db9607cff362023-07-05T17:54:16ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-07-011010.3389/fcvm.2023.12250141225014The role of m5C methyltransferases in cardiovascular diseasesYan-Yue Wang0Yuan Tian1Yong-Zhen Li2Yi-Fan Liu3Yu-Yan Zhao4Lin-Hui Chen5Chi Zhang6Key Lab for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China, Hengyang, ChinaKey Lab for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China, Hengyang, ChinaKey Lab for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China, Hengyang, ChinaResearchLaboratory of Translational Medicine, Hengyang Medical School, University of South China, Hengyang, ChinaKey Lab for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China, Hengyang, ChinaKey Lab for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China, Hengyang, ChinaKey Lab for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China, Hengyang, ChinaThe global leading cause of death is cardiovascular disease (CVD). Although advances in prevention and treatment have been made, the role of RNA epigenetics in CVD is not fully understood. Studies have found that RNA modifications regulate gene expression in mammalian cells, and m5C (5-methylcytosine) is a recently discovered RNA modification that plays a role in gene regulation. As a result of these developments, there has been renewed interest in elucidating the nature and function of RNA “epitranscriptomic” modifications. Recent studies on m5C RNA methylomes, their functions, and the proteins that initiate, translate and manipulate this modification are discussed in this review. This review improves the understanding of m5C modifications and their properties, functions, and implications in cardiac pathologies, including cardiomyopathy, heart failure, and atherosclerosis.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1225014/fullRNA modificationm5C methyltransferasescardiovascular diseasesatherosclerosismitochondrial dysfunction |
| spellingShingle | Yan-Yue Wang Yuan Tian Yong-Zhen Li Yi-Fan Liu Yu-Yan Zhao Lin-Hui Chen Chi Zhang The role of m5C methyltransferases in cardiovascular diseases Frontiers in Cardiovascular Medicine RNA modification m5C methyltransferases cardiovascular diseases atherosclerosis mitochondrial dysfunction |
| title | The role of m5C methyltransferases in cardiovascular diseases |
| title_full | The role of m5C methyltransferases in cardiovascular diseases |
| title_fullStr | The role of m5C methyltransferases in cardiovascular diseases |
| title_full_unstemmed | The role of m5C methyltransferases in cardiovascular diseases |
| title_short | The role of m5C methyltransferases in cardiovascular diseases |
| title_sort | role of m5c methyltransferases in cardiovascular diseases |
| topic | RNA modification m5C methyltransferases cardiovascular diseases atherosclerosis mitochondrial dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1225014/full |
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