Assessing the burden of Taenia solium cysticercosis in Burundi, 2020
Abstract Background Taenia solium cysticercosis is a zoonotic disease that is endemic in many low- and middle-income countries where risk factors for disease transmission are present. The economic impact of cysticercosis on public health and on the pig production sector is not well known in many of...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-022-07849-7 |
| _version_ | 1811319651577102336 |
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| author | Salvator Minani Brecht Devleesschauwer Anastasie Gasogo Jean-Bosco Ntirandekura Sarah Gabriël Pierre Dorny Chiara Trevisan |
| author_facet | Salvator Minani Brecht Devleesschauwer Anastasie Gasogo Jean-Bosco Ntirandekura Sarah Gabriël Pierre Dorny Chiara Trevisan |
| author_sort | Salvator Minani |
| collection | DOAJ |
| description | Abstract Background Taenia solium cysticercosis is a zoonotic disease that is endemic in many low- and middle-income countries where risk factors for disease transmission are present. The economic impact of cysticercosis on public health and on the pig production sector is not well known in many of those countries, including Burundi. This study aimed at estimating the burden of T. solium cysticercosis in Burundi including data on humans and pigs. Methods Epidemiological and economic data were collected from literature up to July 30, 2021 and governmental and non-governmental agencies. Direct and indirect costs for neurocysticercosis (NCC)-associated epilepsy and losses due to porcine cysticercosis were estimated to assess the economic burden, while the health burden was estimated using zoonotic disability-adjusted life years (zDALYs). Different probability distributions (Uniform, Beta, Dirichlet and Gamma) were applied depending on the type of epidemiological parameter. Monte Carlo simulations and 100,000 iterations were used to calculate the 95% uncertainty interval (UI) for each parameter and perform sensitivity analyses. Results In Burundi, 4.26 million USD (95% UI, 1,858,308–8,190,951) were estimated as economic impact due to T. solium cysticercosis in humans and pigs, of which 40.2% (95% UI, 10.3–75.1) of the total costs were due to NCC-associated epilepsy and 59.8% (95% UI, 24.9–89.7) of the losses due to porcine cysticercosis. The cost per NCC-associated epilepsy case was 72 USD (95% UI, 25–168), representing 30.8% of the GDP per capita in 2020. The probable incident cases and deaths for NCC-associated epilepsy were 9065 (95% UI, 2370–16,716) and 61 (95% UI, 16–114), respectively. More than 2 zDALYs (95% UI, 1.1–3.4) per thousand person-years was estimated, of which an average of 1.3 DALYs [0;0] (95% UI, 0.3–2.6) was due to NCC- associated epilepsy and 0.8 animal loss equivalents (ALEs) (95% UI, 0.3–1.5) due to porcine cysticercosis. Conclusions This study provides evidence of a significant burden of T. solium cysticercosis for Burundi’s population. We urge policy makers to use these evidence-based results and put T. solium cysticercosis on the public health agenda of the country. This study recommends urgent action to find solutions for integrated control strategies for T. solium cysticercosis in Burundi. |
| first_indexed | 2024-04-13T12:46:31Z |
| format | Article |
| id | doaj.art-5102e177198b4b6e8607c9f201893dd4 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-13T12:46:31Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-5102e177198b4b6e8607c9f201893dd42022-12-22T02:46:21ZengBMCBMC Infectious Diseases1471-23342022-11-0122111310.1186/s12879-022-07849-7Assessing the burden of Taenia solium cysticercosis in Burundi, 2020Salvator Minani0Brecht Devleesschauwer1Anastasie Gasogo2Jean-Bosco Ntirandekura3Sarah Gabriël4Pierre Dorny5Chiara Trevisan6Department of Biology, Faculty of Sciences, University of BurundiLaboratory of Foodborne Parasitic Zoonoses, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent UniversityDepartment of Biology, Faculty of Sciences, University of BurundiDepartment of Animal Health and Productions, Faculty of Agronomy and Bio-Engineering (FABI), University of BurundiLaboratory of Foodborne Parasitic Zoonoses, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent UniversityDepartment of Biomedical Sciences, Institute of Tropical MedicineDepartment of Biomedical Sciences, Institute of Tropical MedicineAbstract Background Taenia solium cysticercosis is a zoonotic disease that is endemic in many low- and middle-income countries where risk factors for disease transmission are present. The economic impact of cysticercosis on public health and on the pig production sector is not well known in many of those countries, including Burundi. This study aimed at estimating the burden of T. solium cysticercosis in Burundi including data on humans and pigs. Methods Epidemiological and economic data were collected from literature up to July 30, 2021 and governmental and non-governmental agencies. Direct and indirect costs for neurocysticercosis (NCC)-associated epilepsy and losses due to porcine cysticercosis were estimated to assess the economic burden, while the health burden was estimated using zoonotic disability-adjusted life years (zDALYs). Different probability distributions (Uniform, Beta, Dirichlet and Gamma) were applied depending on the type of epidemiological parameter. Monte Carlo simulations and 100,000 iterations were used to calculate the 95% uncertainty interval (UI) for each parameter and perform sensitivity analyses. Results In Burundi, 4.26 million USD (95% UI, 1,858,308–8,190,951) were estimated as economic impact due to T. solium cysticercosis in humans and pigs, of which 40.2% (95% UI, 10.3–75.1) of the total costs were due to NCC-associated epilepsy and 59.8% (95% UI, 24.9–89.7) of the losses due to porcine cysticercosis. The cost per NCC-associated epilepsy case was 72 USD (95% UI, 25–168), representing 30.8% of the GDP per capita in 2020. The probable incident cases and deaths for NCC-associated epilepsy were 9065 (95% UI, 2370–16,716) and 61 (95% UI, 16–114), respectively. More than 2 zDALYs (95% UI, 1.1–3.4) per thousand person-years was estimated, of which an average of 1.3 DALYs [0;0] (95% UI, 0.3–2.6) was due to NCC- associated epilepsy and 0.8 animal loss equivalents (ALEs) (95% UI, 0.3–1.5) due to porcine cysticercosis. Conclusions This study provides evidence of a significant burden of T. solium cysticercosis for Burundi’s population. We urge policy makers to use these evidence-based results and put T. solium cysticercosis on the public health agenda of the country. This study recommends urgent action to find solutions for integrated control strategies for T. solium cysticercosis in Burundi.https://doi.org/10.1186/s12879-022-07849-7Taenia soliumCysticercosisNeurocysticercosisBurdenzDALYEconomic impact |
| spellingShingle | Salvator Minani Brecht Devleesschauwer Anastasie Gasogo Jean-Bosco Ntirandekura Sarah Gabriël Pierre Dorny Chiara Trevisan Assessing the burden of Taenia solium cysticercosis in Burundi, 2020 BMC Infectious Diseases Taenia solium Cysticercosis Neurocysticercosis Burden zDALY Economic impact |
| title | Assessing the burden of Taenia solium cysticercosis in Burundi, 2020 |
| title_full | Assessing the burden of Taenia solium cysticercosis in Burundi, 2020 |
| title_fullStr | Assessing the burden of Taenia solium cysticercosis in Burundi, 2020 |
| title_full_unstemmed | Assessing the burden of Taenia solium cysticercosis in Burundi, 2020 |
| title_short | Assessing the burden of Taenia solium cysticercosis in Burundi, 2020 |
| title_sort | assessing the burden of taenia solium cysticercosis in burundi 2020 |
| topic | Taenia solium Cysticercosis Neurocysticercosis Burden zDALY Economic impact |
| url | https://doi.org/10.1186/s12879-022-07849-7 |
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