Paramagnetic NMR investigation of dendrimer-based host-guest interactions.
In this study, the host-guest behavior of poly(amidoamine) (PAMAM) dendrimers bearing amine, hydroxyl, or carboxylate surface functionalities were investigated by paramagnetic NMR studies. 2,2,6,6-Tetramethylpiperidinyloxy (TEMPO) derivatives were used as paramagnetic guest molecules. The results sh...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3677888?pdf=render |
| _version_ | 1818142253141458944 |
|---|---|
| author | Fei Wang Naimin Shao Yiyun Cheng |
| author_facet | Fei Wang Naimin Shao Yiyun Cheng |
| author_sort | Fei Wang |
| collection | DOAJ |
| description | In this study, the host-guest behavior of poly(amidoamine) (PAMAM) dendrimers bearing amine, hydroxyl, or carboxylate surface functionalities were investigated by paramagnetic NMR studies. 2,2,6,6-Tetramethylpiperidinyloxy (TEMPO) derivatives were used as paramagnetic guest molecules. The results showed that TEMPO-COOH significantly broaden the ¹H NMR peaks of amine- and hydroxyl-terminated PAMAM dendrimers. In comparison, no paramagnetic relaxation enhancement (PRE) was observed between TEMPO-NH₂, TEMPO-OH and the three types of PAMAM dendrimers. The PRE phenomenon observed is correlated with the encapsulation of TEMPO-COOH within dendrimer pockets. Protonation of the tertiary amine groups within PAMAM dendrimers plays an important role during this process. Interestingly, the absence of TEMPO-COOH encapsulation within carboxylate-terminated PAMAM dendrimer is observed due to the repulsion of TEMPO-COO- anion and anionic dendrimer surface. The combination of paramagnetic probes and ¹H NMR linewidth analysis can be used as a powerful tool in the analysis of dendrimer-based host-guest systems. |
| first_indexed | 2024-12-11T11:12:50Z |
| format | Article |
| id | doaj.art-5103657399b043f3a548b8a89891bfdd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T11:12:50Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5103657399b043f3a548b8a89891bfdd2022-12-22T01:09:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0186e6472210.1371/journal.pone.0064722Paramagnetic NMR investigation of dendrimer-based host-guest interactions.Fei WangNaimin ShaoYiyun ChengIn this study, the host-guest behavior of poly(amidoamine) (PAMAM) dendrimers bearing amine, hydroxyl, or carboxylate surface functionalities were investigated by paramagnetic NMR studies. 2,2,6,6-Tetramethylpiperidinyloxy (TEMPO) derivatives were used as paramagnetic guest molecules. The results showed that TEMPO-COOH significantly broaden the ¹H NMR peaks of amine- and hydroxyl-terminated PAMAM dendrimers. In comparison, no paramagnetic relaxation enhancement (PRE) was observed between TEMPO-NH₂, TEMPO-OH and the three types of PAMAM dendrimers. The PRE phenomenon observed is correlated with the encapsulation of TEMPO-COOH within dendrimer pockets. Protonation of the tertiary amine groups within PAMAM dendrimers plays an important role during this process. Interestingly, the absence of TEMPO-COOH encapsulation within carboxylate-terminated PAMAM dendrimer is observed due to the repulsion of TEMPO-COO- anion and anionic dendrimer surface. The combination of paramagnetic probes and ¹H NMR linewidth analysis can be used as a powerful tool in the analysis of dendrimer-based host-guest systems.http://europepmc.org/articles/PMC3677888?pdf=render |
| spellingShingle | Fei Wang Naimin Shao Yiyun Cheng Paramagnetic NMR investigation of dendrimer-based host-guest interactions. PLoS ONE |
| title | Paramagnetic NMR investigation of dendrimer-based host-guest interactions. |
| title_full | Paramagnetic NMR investigation of dendrimer-based host-guest interactions. |
| title_fullStr | Paramagnetic NMR investigation of dendrimer-based host-guest interactions. |
| title_full_unstemmed | Paramagnetic NMR investigation of dendrimer-based host-guest interactions. |
| title_short | Paramagnetic NMR investigation of dendrimer-based host-guest interactions. |
| title_sort | paramagnetic nmr investigation of dendrimer based host guest interactions |
| url | http://europepmc.org/articles/PMC3677888?pdf=render |
| work_keys_str_mv | AT feiwang paramagneticnmrinvestigationofdendrimerbasedhostguestinteractions AT naiminshao paramagneticnmrinvestigationofdendrimerbasedhostguestinteractions AT yiyuncheng paramagneticnmrinvestigationofdendrimerbasedhostguestinteractions |