Interaction of Alcohol Consumption and <i>ABCG2</i> rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population
Background: <i>ABCG2</i> rs2231142 is an important genetic factor that contributes to the development of gout and hyperuricemia (HUA). Epidemiologic studies have demonstrated that lifestyle risk factors of HUA (e.g., alcohol consumption) and genetic predisposition (e.g., <i>ABCG2&l...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/11/11/1158 |
| _version_ | 1797509708876087296 |
|---|---|
| author | I-Chieh Chen Yen-Ju Chen Yi-Ming Chen Hsueh-Ju Lin Ying-Cheng Lin Jui-Chun Chagn Pei-Chun Chen Ching-Heng Lin |
| author_facet | I-Chieh Chen Yen-Ju Chen Yi-Ming Chen Hsueh-Ju Lin Ying-Cheng Lin Jui-Chun Chagn Pei-Chun Chen Ching-Heng Lin |
| author_sort | I-Chieh Chen |
| collection | DOAJ |
| description | Background: <i>ABCG2</i> rs2231142 is an important genetic factor that contributes to the development of gout and hyperuricemia (HUA). Epidemiologic studies have demonstrated that lifestyle risk factors of HUA (e.g., alcohol consumption) and genetic predisposition (e.g., <i>ABCG2</i> gene) together, contribute to enhanced serum uric acid levels. However, the interaction between <i>ABCG2</i> rs2231142, alcohol consumption, and HUA in the Taiwanese population is still unclear. Therefore, this study investigated whether the risk of HUA is associated with <i>ABCG2</i> rs2231142 variants and how this is affected by alcohol consumption. Method: study subjects were selected from the participants of the Taiwan Biobank database. Overall, 114,540 participants aged 30 to 70 years were enrolled in this study. The interaction between <i>ABCG2</i> rs2231142, alcohol consumption, and serum uric acid (sUA) levels was analyzed by multiple logistic regression models. Results: the prevalence of HUA was 32.7% and 4.4 % in the male and female populations, respectively. In the whole study population, the minor T allele of <i>ABCG2</i> rs2231142 was significantly associated with HUA risk, and the occurrence of HUA was high in TT genotype and TG genotype. The risk of HUA was significantly increased by the combined association of <i>ABCG2</i> rs2231142 and alcohol consumption for TG/TT genotype compared to the GG genotype (wild-type genotype), especially among women. Conclusion: the <i>ABCG2</i> rs2231142 is a crucial genetic locus for sUA levels in the Taiwanese population and our findings revealed that alcohol consumption combined with the <i>ABCG2</i> rs2231142 risk allele contributes to increased HUA risk. |
| first_indexed | 2024-03-10T05:21:36Z |
| format | Article |
| id | doaj.art-51041bb6506d49b2949d44f338ea22f1 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T05:21:36Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-51041bb6506d49b2949d44f338ea22f12023-11-22T23:58:46ZengMDPI AGJournal of Personalized Medicine2075-44262021-11-011111115810.3390/jpm11111158Interaction of Alcohol Consumption and <i>ABCG2</i> rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese PopulationI-Chieh Chen0Yen-Ju Chen1Yi-Ming Chen2Hsueh-Ju Lin3Ying-Cheng Lin4Jui-Chun Chagn5Pei-Chun Chen6Ching-Heng Lin7Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung 40705, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung 40705, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung 40705, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, TaiwanDepartment of Obstetrics and Gynecology and Women’s Health, Taichung Veterans General Hospital, Taichung 40705, TaiwanDepartment of Mathematics and Information Education, National Taipei University of Education, Taipei City 10671, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung 40705, TaiwanBackground: <i>ABCG2</i> rs2231142 is an important genetic factor that contributes to the development of gout and hyperuricemia (HUA). Epidemiologic studies have demonstrated that lifestyle risk factors of HUA (e.g., alcohol consumption) and genetic predisposition (e.g., <i>ABCG2</i> gene) together, contribute to enhanced serum uric acid levels. However, the interaction between <i>ABCG2</i> rs2231142, alcohol consumption, and HUA in the Taiwanese population is still unclear. Therefore, this study investigated whether the risk of HUA is associated with <i>ABCG2</i> rs2231142 variants and how this is affected by alcohol consumption. Method: study subjects were selected from the participants of the Taiwan Biobank database. Overall, 114,540 participants aged 30 to 70 years were enrolled in this study. The interaction between <i>ABCG2</i> rs2231142, alcohol consumption, and serum uric acid (sUA) levels was analyzed by multiple logistic regression models. Results: the prevalence of HUA was 32.7% and 4.4 % in the male and female populations, respectively. In the whole study population, the minor T allele of <i>ABCG2</i> rs2231142 was significantly associated with HUA risk, and the occurrence of HUA was high in TT genotype and TG genotype. The risk of HUA was significantly increased by the combined association of <i>ABCG2</i> rs2231142 and alcohol consumption for TG/TT genotype compared to the GG genotype (wild-type genotype), especially among women. Conclusion: the <i>ABCG2</i> rs2231142 is a crucial genetic locus for sUA levels in the Taiwanese population and our findings revealed that alcohol consumption combined with the <i>ABCG2</i> rs2231142 risk allele contributes to increased HUA risk.https://www.mdpi.com/2075-4426/11/11/1158hyperuricemiaserum uric acid levelsalcohol consumption<i>ABCG2</i> rs2231142 |
| spellingShingle | I-Chieh Chen Yen-Ju Chen Yi-Ming Chen Hsueh-Ju Lin Ying-Cheng Lin Jui-Chun Chagn Pei-Chun Chen Ching-Heng Lin Interaction of Alcohol Consumption and <i>ABCG2</i> rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population Journal of Personalized Medicine hyperuricemia serum uric acid levels alcohol consumption <i>ABCG2</i> rs2231142 |
| title | Interaction of Alcohol Consumption and <i>ABCG2</i> rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population |
| title_full | Interaction of Alcohol Consumption and <i>ABCG2</i> rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population |
| title_fullStr | Interaction of Alcohol Consumption and <i>ABCG2</i> rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population |
| title_full_unstemmed | Interaction of Alcohol Consumption and <i>ABCG2</i> rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population |
| title_short | Interaction of Alcohol Consumption and <i>ABCG2</i> rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population |
| title_sort | interaction of alcohol consumption and i abcg2 i rs2231142 variant contributes to hyperuricemia in a taiwanese population |
| topic | hyperuricemia serum uric acid levels alcohol consumption <i>ABCG2</i> rs2231142 |
| url | https://www.mdpi.com/2075-4426/11/11/1158 |
| work_keys_str_mv | AT ichiehchen interactionofalcoholconsumptionandiabcg2irs2231142variantcontributestohyperuricemiainataiwanesepopulation AT yenjuchen interactionofalcoholconsumptionandiabcg2irs2231142variantcontributestohyperuricemiainataiwanesepopulation AT yimingchen interactionofalcoholconsumptionandiabcg2irs2231142variantcontributestohyperuricemiainataiwanesepopulation AT hsuehjulin interactionofalcoholconsumptionandiabcg2irs2231142variantcontributestohyperuricemiainataiwanesepopulation AT yingchenglin interactionofalcoholconsumptionandiabcg2irs2231142variantcontributestohyperuricemiainataiwanesepopulation AT juichunchagn interactionofalcoholconsumptionandiabcg2irs2231142variantcontributestohyperuricemiainataiwanesepopulation AT peichunchen interactionofalcoholconsumptionandiabcg2irs2231142variantcontributestohyperuricemiainataiwanesepopulation AT chinghenglin interactionofalcoholconsumptionandiabcg2irs2231142variantcontributestohyperuricemiainataiwanesepopulation |