Pharmacological basis for the medicinal use of Rhus coriaria in hyperactive gut disorders
This study was aimed at providing the pharmacological basis for the medicinal use of Rhus coriaria in diarrhea. In mice, the crude of R. coriaria demonstrated antisecretory and antidiarrheal effects against castor oil-induced fluid accumulation and diarrhea at at 100 and 300 mg/kg, respectively, and...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2014-12-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | http://www.banglajol.info/bd/index.php/BJP/article/view/20879 |
| _version_ | 1811212957927866368 |
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| author | Khalid Hussain Janbaz Arham Shabbir Malik Hassan Mehmood Anwarul Hassan Gilani |
| author_facet | Khalid Hussain Janbaz Arham Shabbir Malik Hassan Mehmood Anwarul Hassan Gilani |
| author_sort | Khalid Hussain Janbaz |
| collection | DOAJ |
| description | This study was aimed at providing the pharmacological basis for the medicinal use of Rhus coriaria in diarrhea. In mice, the crude of R. coriaria demonstrated antisecretory and antidiarrheal effects against castor oil-induced fluid accumulation and diarrhea at at 100 and 300 mg/kg, respectively, and was found safe up to tested dose of 5 g/kg. In isolated rabbit jejunum, R. coriaria exhibited concentration-dependent (0.01-3.0 mg/mL) relaxation of spontaneous and high K+ (80 mM)-induced contractions, similar to verapamil. The Ca++ antagonist activity was confirmed when pretreatment of R. coriaria shifted Ca++ concentration-response curves to the right with suppression of maximal response, similar to verapamil. R. coriaria also suppressed the high K+-evoked transient contractile peaks similar to the effect of cyclopiazonic acid and verapamil. This study indicates that R. coriaria possesses antisecretory, antidiarrheal and antispasmodic properties mediated possibly through Ca++ antagonist pathway, thus providing evidence to its medicinal use in diarrhea and abdominal spasm. |
| first_indexed | 2024-04-12T05:38:40Z |
| format | Article |
| id | doaj.art-5104bf2a16f44689a191ccf083020951 |
| institution | Directory Open Access Journal |
| issn | 1991-007X 1991-0088 |
| language | English |
| last_indexed | 2024-04-12T05:38:40Z |
| publishDate | 2014-12-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-5104bf2a16f44689a191ccf0830209512022-12-22T03:45:45ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-007X1991-00882014-12-0194636644Pharmacological basis for the medicinal use of Rhus coriaria in hyperactive gut disordersKhalid Hussain Janbaz Arham ShabbirMalik Hassan MehmoodAnwarul Hassan GilaniThis study was aimed at providing the pharmacological basis for the medicinal use of Rhus coriaria in diarrhea. In mice, the crude of R. coriaria demonstrated antisecretory and antidiarrheal effects against castor oil-induced fluid accumulation and diarrhea at at 100 and 300 mg/kg, respectively, and was found safe up to tested dose of 5 g/kg. In isolated rabbit jejunum, R. coriaria exhibited concentration-dependent (0.01-3.0 mg/mL) relaxation of spontaneous and high K+ (80 mM)-induced contractions, similar to verapamil. The Ca++ antagonist activity was confirmed when pretreatment of R. coriaria shifted Ca++ concentration-response curves to the right with suppression of maximal response, similar to verapamil. R. coriaria also suppressed the high K+-evoked transient contractile peaks similar to the effect of cyclopiazonic acid and verapamil. This study indicates that R. coriaria possesses antisecretory, antidiarrheal and antispasmodic properties mediated possibly through Ca++ antagonist pathway, thus providing evidence to its medicinal use in diarrhea and abdominal spasm.http://www.banglajol.info/bd/index.php/BJP/article/view/20879AntidiarrhealAntisecretoryAntispasmodicCa++antagonistRhus coriaria |
| spellingShingle | Khalid Hussain Janbaz Arham Shabbir Malik Hassan Mehmood Anwarul Hassan Gilani Pharmacological basis for the medicinal use of Rhus coriaria in hyperactive gut disorders Bangladesh Journal of Pharmacology Antidiarrheal Antisecretory Antispasmodic Ca++antagonist Rhus coriaria |
| title | Pharmacological basis for the medicinal use of Rhus coriaria in hyperactive gut disorders |
| title_full | Pharmacological basis for the medicinal use of Rhus coriaria in hyperactive gut disorders |
| title_fullStr | Pharmacological basis for the medicinal use of Rhus coriaria in hyperactive gut disorders |
| title_full_unstemmed | Pharmacological basis for the medicinal use of Rhus coriaria in hyperactive gut disorders |
| title_short | Pharmacological basis for the medicinal use of Rhus coriaria in hyperactive gut disorders |
| title_sort | pharmacological basis for the medicinal use of rhus coriaria in hyperactive gut disorders |
| topic | Antidiarrheal Antisecretory Antispasmodic Ca++antagonist Rhus coriaria |
| url | http://www.banglajol.info/bd/index.php/BJP/article/view/20879 |
| work_keys_str_mv | AT khalidhussainjanbaz pharmacologicalbasisforthemedicinaluseofrhuscoriariainhyperactivegutdisorders AT arhamshabbir pharmacologicalbasisforthemedicinaluseofrhuscoriariainhyperactivegutdisorders AT malikhassanmehmood pharmacologicalbasisforthemedicinaluseofrhuscoriariainhyperactivegutdisorders AT anwarulhassangilani pharmacologicalbasisforthemedicinaluseofrhuscoriariainhyperactivegutdisorders |