Neuroprotective effects of meloxicam on transient brain ischemia in rats: the two faces of anti-inflammatory treatments
The inflammatory response plays an important role in neuroprotection and regeneration after ischemic insult. The use of non-steroidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental effects. In this context, the effects of the anti-inflammatory a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Neural Regeneration Research |
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| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=9;spage=1961;epage=1967;aulast=Ugidos |
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| author | Irene Fernández Ugidos Paloma González-Rodríguez María Santos-Galdiano Enrique Font-Belmonte Berta Anuncibay-Soto Diego Pérez-Rodríguez José Manuel Gonzalo-Orden Arsenio Fernández-López |
| author_facet | Irene Fernández Ugidos Paloma González-Rodríguez María Santos-Galdiano Enrique Font-Belmonte Berta Anuncibay-Soto Diego Pérez-Rodríguez José Manuel Gonzalo-Orden Arsenio Fernández-López |
| author_sort | Irene Fernández Ugidos |
| collection | DOAJ |
| description | The inflammatory response plays an important role in neuroprotection and regeneration after ischemic insult. The use of non-steroidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental effects. In this context, the effects of the anti-inflammatory agent meloxicam have been scarcely documented after stroke, but its ability to inhibit both cyclooxygenase isoforms (1 and 2) could be a promising strategy to modulate post-ischemic inflammation. This study analyzed the effect of meloxicam in a transient focal cerebral ischemia model in rats, measuring its neuroprotective effect after 48 hours and 7 days of reperfusion and the effects of the treatment on the glial scar and regenerative events such as the generation of new progenitors in the subventricular zone and axonal sprouting at the edge of the damaged area. We show that meloxicam’s neuroprotective effects remained after 7 days of reperfusion even if its administration was restricted to the two first days after ischemia. Moreover, meloxicam treatment modulated glial scar reactivity, which matched with an increase in axonal sprouting. However, this treatment decreased the formation of neuronal progenitor cells. This study discusses the dual role of anti-inflammatory treatments after stroke and encourages the careful analysis of both the neuroprotective and the regenerative effects in preclinical studies. |
| first_indexed | 2024-04-09T23:24:01Z |
| format | Article |
| id | doaj.art-51051db0df904bb796a259eac9e34e94 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-09T23:24:01Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-51051db0df904bb796a259eac9e34e942023-03-21T11:23:56ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742023-01-011891961196710.4103/1673-5374.367846Neuroprotective effects of meloxicam on transient brain ischemia in rats: the two faces of anti-inflammatory treatmentsIrene Fernández UgidosPaloma González-RodríguezMaría Santos-GaldianoEnrique Font-BelmonteBerta Anuncibay-SotoDiego Pérez-RodríguezJosé Manuel Gonzalo-OrdenArsenio Fernández-LópezThe inflammatory response plays an important role in neuroprotection and regeneration after ischemic insult. The use of non-steroidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental effects. In this context, the effects of the anti-inflammatory agent meloxicam have been scarcely documented after stroke, but its ability to inhibit both cyclooxygenase isoforms (1 and 2) could be a promising strategy to modulate post-ischemic inflammation. This study analyzed the effect of meloxicam in a transient focal cerebral ischemia model in rats, measuring its neuroprotective effect after 48 hours and 7 days of reperfusion and the effects of the treatment on the glial scar and regenerative events such as the generation of new progenitors in the subventricular zone and axonal sprouting at the edge of the damaged area. We show that meloxicam’s neuroprotective effects remained after 7 days of reperfusion even if its administration was restricted to the two first days after ischemia. Moreover, meloxicam treatment modulated glial scar reactivity, which matched with an increase in axonal sprouting. However, this treatment decreased the formation of neuronal progenitor cells. This study discusses the dual role of anti-inflammatory treatments after stroke and encourages the careful analysis of both the neuroprotective and the regenerative effects in preclinical studies.http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=9;spage=1961;epage=1967;aulast=Ugidosanti-inflammatories; astrocyte; axonal sprouting; cylinder test; doublecortin; focal brain ischemia; glial scar; inflammation; neuroprotection; new neuron generation; transient stroke |
| spellingShingle | Irene Fernández Ugidos Paloma González-Rodríguez María Santos-Galdiano Enrique Font-Belmonte Berta Anuncibay-Soto Diego Pérez-Rodríguez José Manuel Gonzalo-Orden Arsenio Fernández-López Neuroprotective effects of meloxicam on transient brain ischemia in rats: the two faces of anti-inflammatory treatments Neural Regeneration Research anti-inflammatories; astrocyte; axonal sprouting; cylinder test; doublecortin; focal brain ischemia; glial scar; inflammation; neuroprotection; new neuron generation; transient stroke |
| title | Neuroprotective effects of meloxicam on transient brain ischemia in rats: the two faces of anti-inflammatory treatments |
| title_full | Neuroprotective effects of meloxicam on transient brain ischemia in rats: the two faces of anti-inflammatory treatments |
| title_fullStr | Neuroprotective effects of meloxicam on transient brain ischemia in rats: the two faces of anti-inflammatory treatments |
| title_full_unstemmed | Neuroprotective effects of meloxicam on transient brain ischemia in rats: the two faces of anti-inflammatory treatments |
| title_short | Neuroprotective effects of meloxicam on transient brain ischemia in rats: the two faces of anti-inflammatory treatments |
| title_sort | neuroprotective effects of meloxicam on transient brain ischemia in rats the two faces of anti inflammatory treatments |
| topic | anti-inflammatories; astrocyte; axonal sprouting; cylinder test; doublecortin; focal brain ischemia; glial scar; inflammation; neuroprotection; new neuron generation; transient stroke |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=9;spage=1961;epage=1967;aulast=Ugidos |
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