Interactions between Nanoparticles and Intestine
The use of nanoparticles (NPs) has surely grown in recent years due to their versatility, with a spectrum of applications that range from nanomedicine to the food industry. Recent research focuses on the development of NPs for the oral administration route rather than the intravenous one, placing th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/8/4339 |
| _version_ | 1797445873412603904 |
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| author | Manuela Vitulo Elisa Gnodi Raffaella Meneveri Donatella Barisani |
| author_facet | Manuela Vitulo Elisa Gnodi Raffaella Meneveri Donatella Barisani |
| author_sort | Manuela Vitulo |
| collection | DOAJ |
| description | The use of nanoparticles (NPs) has surely grown in recent years due to their versatility, with a spectrum of applications that range from nanomedicine to the food industry. Recent research focuses on the development of NPs for the oral administration route rather than the intravenous one, placing the interactions between NPs and the intestine at the centre of the attention. This allows the NPs functionalization to exploit the different characteristics of the digestive tract, such as the different pH, the intestinal mucus layer, or the intestinal absorption capacity. On the other hand, these same characteristics can represent a problem for their complexity, also considering the potential interactions with the food matrix or the microbiota. This review intends to give a comprehensive look into three main branches of NPs delivery through the oral route: the functionalization of NPs drug carriers for systemic targets, with the case of insulin carriers as an example; NPs for the delivery of drugs locally active in the intestine, for the treatment of inflammatory bowel diseases and colon cancer; finally, the potential concerns and side effects of the accidental and uncontrolled exposure to NPs employed as food additives, with focus on E171 (titanium dioxide) and E174 (silver NPs). |
| first_indexed | 2024-03-09T13:33:05Z |
| format | Article |
| id | doaj.art-5105f4ecf9214b2bbacfa00b39db48ee |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T13:33:05Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5105f4ecf9214b2bbacfa00b39db48ee2023-11-30T21:15:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01238433910.3390/ijms23084339Interactions between Nanoparticles and IntestineManuela Vitulo0Elisa Gnodi1Raffaella Meneveri2Donatella Barisani3School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, ItalySchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, ItalySchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, ItalySchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, ItalyThe use of nanoparticles (NPs) has surely grown in recent years due to their versatility, with a spectrum of applications that range from nanomedicine to the food industry. Recent research focuses on the development of NPs for the oral administration route rather than the intravenous one, placing the interactions between NPs and the intestine at the centre of the attention. This allows the NPs functionalization to exploit the different characteristics of the digestive tract, such as the different pH, the intestinal mucus layer, or the intestinal absorption capacity. On the other hand, these same characteristics can represent a problem for their complexity, also considering the potential interactions with the food matrix or the microbiota. This review intends to give a comprehensive look into three main branches of NPs delivery through the oral route: the functionalization of NPs drug carriers for systemic targets, with the case of insulin carriers as an example; NPs for the delivery of drugs locally active in the intestine, for the treatment of inflammatory bowel diseases and colon cancer; finally, the potential concerns and side effects of the accidental and uncontrolled exposure to NPs employed as food additives, with focus on E171 (titanium dioxide) and E174 (silver NPs).https://www.mdpi.com/1422-0067/23/8/4339nanoparticlesnanocarriersinsulin deliveryinflammatory bowel diseasescolon cancerfood additives |
| spellingShingle | Manuela Vitulo Elisa Gnodi Raffaella Meneveri Donatella Barisani Interactions between Nanoparticles and Intestine International Journal of Molecular Sciences nanoparticles nanocarriers insulin delivery inflammatory bowel diseases colon cancer food additives |
| title | Interactions between Nanoparticles and Intestine |
| title_full | Interactions between Nanoparticles and Intestine |
| title_fullStr | Interactions between Nanoparticles and Intestine |
| title_full_unstemmed | Interactions between Nanoparticles and Intestine |
| title_short | Interactions between Nanoparticles and Intestine |
| title_sort | interactions between nanoparticles and intestine |
| topic | nanoparticles nanocarriers insulin delivery inflammatory bowel diseases colon cancer food additives |
| url | https://www.mdpi.com/1422-0067/23/8/4339 |
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