Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s Disease
Transcranial alternating current stimulation (tACS) is a neuromodulation procedure that is currently studied for the purpose of improving cognitive function in various diseases. A few studies have shown positive effects of tACS in Alzheimer’s disease (AD). However, the mechanism underlying tACS has...
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MDPI AG
2021-11-01
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| Online Access: | https://www.mdpi.com/2076-3425/11/11/1532 |
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| author | Won-Hyeong Jeong Wang-In Kim Jin-Won Lee Hyeng-Kyu Park Min-Keun Song In-Sung Choi Jae-Young Han |
| author_facet | Won-Hyeong Jeong Wang-In Kim Jin-Won Lee Hyeng-Kyu Park Min-Keun Song In-Sung Choi Jae-Young Han |
| author_sort | Won-Hyeong Jeong |
| collection | DOAJ |
| description | Transcranial alternating current stimulation (tACS) is a neuromodulation procedure that is currently studied for the purpose of improving cognitive function in various diseases. A few studies have shown positive effects of tACS in Alzheimer’s disease (AD). However, the mechanism underlying tACS has not been established. The purpose of this study was to investigate the mechanism of tACS in five familial AD mutation (5xFAD) mouse models. We prepared twenty 4-month-old mice and divided them into four groups: wild-type mice without stimulation (WT-NT group), wild-type mice with tACS (WT-T group), 5xFAD mice without stimulation (AD-NT group), and 5xFAD mice with tACS (AD-T group). The protocol implemented was as follows: gamma frequency 200 μA over the bilateral frontal lobe for 20 min over 2 weeks. The following tests were conducted: excitatory postsynaptic potential (EPSP) recording, Western blot analysis (cyclic AMP response element-binding (CREB) proteins, phosphorylated CREB proteins, brain-derived neurotrophic factor, and parvalbumin) to examine the synaptic plasticity. The EPSP was remarkably increased in the AD-T group compared with in the AD-NT group. In the Western blot analysis, the differences among the groups were not significant. Hence, tACS can affect the long-lasting enhancement of synaptic transmission in mice models of AD. |
| first_indexed | 2024-03-10T05:39:15Z |
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| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T05:39:15Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
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| series | Brain Sciences |
| spelling | doaj.art-5107fa790bf54296ab879efaaa5d88cf2023-11-22T22:39:04ZengMDPI AGBrain Sciences2076-34252021-11-011111153210.3390/brainsci11111532Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s DiseaseWon-Hyeong Jeong0Wang-In Kim1Jin-Won Lee2Hyeng-Kyu Park3Min-Keun Song4In-Sung Choi5Jae-Young Han6Department of Physical & Rehabilitation Medicine, Chonnam National University Hospital, Gwangju City 61469, KoreaDepartment of Physical & Rehabilitation Medicine, Chonnam National University Hospital, Gwangju City 61469, KoreaDepartment of Physical & Rehabilitation Medicine, Chonnam National University Hospital, Gwangju City 61469, KoreaDepartment of Physical & Rehabilitation Medicine, Chonnam National University Hospital, Gwangju City 61469, KoreaDepartment of Physical & Rehabilitation Medicine, Regional Cardiocerebrovascular Center, Center for Aging and Geriatrics, Chonnam National University Medical School & Hospital, Gwangju City 61469, KoreaDepartment of Physical & Rehabilitation Medicine, Chonnam National University Hospital, Gwangju City 61469, KoreaDepartment of Physical & Rehabilitation Medicine, Regional Cardiocerebrovascular Center, Center for Aging and Geriatrics, Chonnam National University Medical School & Hospital, Gwangju City 61469, KoreaTranscranial alternating current stimulation (tACS) is a neuromodulation procedure that is currently studied for the purpose of improving cognitive function in various diseases. A few studies have shown positive effects of tACS in Alzheimer’s disease (AD). However, the mechanism underlying tACS has not been established. The purpose of this study was to investigate the mechanism of tACS in five familial AD mutation (5xFAD) mouse models. We prepared twenty 4-month-old mice and divided them into four groups: wild-type mice without stimulation (WT-NT group), wild-type mice with tACS (WT-T group), 5xFAD mice without stimulation (AD-NT group), and 5xFAD mice with tACS (AD-T group). The protocol implemented was as follows: gamma frequency 200 μA over the bilateral frontal lobe for 20 min over 2 weeks. The following tests were conducted: excitatory postsynaptic potential (EPSP) recording, Western blot analysis (cyclic AMP response element-binding (CREB) proteins, phosphorylated CREB proteins, brain-derived neurotrophic factor, and parvalbumin) to examine the synaptic plasticity. The EPSP was remarkably increased in the AD-T group compared with in the AD-NT group. In the Western blot analysis, the differences among the groups were not significant. Hence, tACS can affect the long-lasting enhancement of synaptic transmission in mice models of AD.https://www.mdpi.com/2076-3425/11/11/1532transcranial alternating current stimulationAlzheimer’s diseasenoninvasive brain stimulationgamma frequencylong-term potentiationsynaptic plasticity |
| spellingShingle | Won-Hyeong Jeong Wang-In Kim Jin-Won Lee Hyeng-Kyu Park Min-Keun Song In-Sung Choi Jae-Young Han Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s Disease Brain Sciences transcranial alternating current stimulation Alzheimer’s disease noninvasive brain stimulation gamma frequency long-term potentiation synaptic plasticity |
| title | Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s Disease |
| title_full | Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s Disease |
| title_fullStr | Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s Disease |
| title_full_unstemmed | Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s Disease |
| title_short | Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer’s Disease |
| title_sort | modulation of long term potentiation by gamma frequency transcranial alternating current stimulation in transgenic mouse models of alzheimer s disease |
| topic | transcranial alternating current stimulation Alzheimer’s disease noninvasive brain stimulation gamma frequency long-term potentiation synaptic plasticity |
| url | https://www.mdpi.com/2076-3425/11/11/1532 |
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