Tumour endothelial cells for translational research and therapeutics
Abstract Tumour vascularization plays an important role in tumour development and progression. Tumour endothelial cells (TECs) form the inner lining of tumour blood vessels. TECs are mainly derived from endothelial progenitor cells (EPCs); however, it is increasingly evident that in some tumours, TE...
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| Format: | Article |
| Language: | English |
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Wiley
2022-03-01
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| Series: | Clinical and Translational Discovery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctd2.36 |
| _version_ | 1828057256506163200 |
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| author | Linshan Xie Peipei Guo Meng Xiang Yuanlin Song Xiangdong Wang Charles A. Powell Chunxue Bai Dawei Yang |
| author_facet | Linshan Xie Peipei Guo Meng Xiang Yuanlin Song Xiangdong Wang Charles A. Powell Chunxue Bai Dawei Yang |
| author_sort | Linshan Xie |
| collection | DOAJ |
| description | Abstract Tumour vascularization plays an important role in tumour development and progression. Tumour endothelial cells (TECs) form the inner lining of tumour blood vessels. TECs are mainly derived from endothelial progenitor cells (EPCs); however, it is increasingly evident that in some tumours, TECs are also transformed from cancer stem cells. TECs are different from normal endothelial cells (NECs) in many aspects. On the one hand, the hierarchy of TECs is disorganized, leading to perturbed blood flow, and creating a hypoxic microenvironment in the tumour tissues, which stimulates tumour blood vessels to grow into the tumour tissues. However, the normal endothelial structure is intact, and blood flow is smooth. On the other hand, TECs are more dependent on glycolysis, mitochondrial respiration, and fatty acid metabolism, so there are many potential targets for anti‐angiogenesis therapy. TECs and NECs differ in their gene expressions; biological function experiments have demonstrated that TECs and NECs have different phenotypes. This is essentially caused by gene mutations in TECs. Previous reports mostly described TECs as endothelial cells covering the inner surface of tumour blood vessels. Up to now, there is no clear definition of a group of cells as TECs. Based on this, we summarize the characteristics of TECs as follows. (1) They are derived from EPCs or tumour stem cells. (2) They have up‐regulation of glycolysis, mitochondrial respiration, and fatty acid metabolism. (3) They secrete different cytokines. (4) Some TECs highly express epidermal growth factor receptor and interleukin‐4 receptor. (5) They are distributed around or in tumours and play an important role in the processes of tumour growth, development, and metastasis. |
| first_indexed | 2024-04-10T21:09:46Z |
| format | Article |
| id | doaj.art-510aca7593084c58becafb7e1c1a12e1 |
| institution | Directory Open Access Journal |
| issn | 2768-0622 |
| language | English |
| last_indexed | 2024-04-10T21:09:46Z |
| publishDate | 2022-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Discovery |
| spelling | doaj.art-510aca7593084c58becafb7e1c1a12e12023-01-21T04:01:42ZengWileyClinical and Translational Discovery2768-06222022-03-0121n/an/a10.1002/ctd2.36Tumour endothelial cells for translational research and therapeuticsLinshan Xie0Peipei Guo1Meng Xiang2Yuanlin Song3Xiangdong Wang4Charles A. Powell5Chunxue Bai6Dawei Yang7Department of Pulmonary and Critical Care Medicine Zhongshan Hospital Fudan University Shanghai ChinaDepartment of Medicine Division of Pulmonary, Critical care and Sleep Medicine Icahn School of Medicine at Mount Sinai New York New York United StatesDepartment of Physiology and Pathophysiology School of Basic Medical Sciences Fudan University Shanghai ChinaDepartment of Pulmonary and Critical Care Medicine Zhongshan Hospital Fudan University Shanghai ChinaDepartment of Pulmonary and Critical Care Medicine Zhongshan Hospital Fudan University Shanghai ChinaDepartment of Medicine Division of Pulmonary, Critical care and Sleep Medicine Icahn School of Medicine at Mount Sinai New York New York United StatesDepartment of Pulmonary and Critical Care Medicine Zhongshan Hospital Fudan University Shanghai ChinaDepartment of Pulmonary and Critical Care Medicine Zhongshan Hospital Fudan University Shanghai ChinaAbstract Tumour vascularization plays an important role in tumour development and progression. Tumour endothelial cells (TECs) form the inner lining of tumour blood vessels. TECs are mainly derived from endothelial progenitor cells (EPCs); however, it is increasingly evident that in some tumours, TECs are also transformed from cancer stem cells. TECs are different from normal endothelial cells (NECs) in many aspects. On the one hand, the hierarchy of TECs is disorganized, leading to perturbed blood flow, and creating a hypoxic microenvironment in the tumour tissues, which stimulates tumour blood vessels to grow into the tumour tissues. However, the normal endothelial structure is intact, and blood flow is smooth. On the other hand, TECs are more dependent on glycolysis, mitochondrial respiration, and fatty acid metabolism, so there are many potential targets for anti‐angiogenesis therapy. TECs and NECs differ in their gene expressions; biological function experiments have demonstrated that TECs and NECs have different phenotypes. This is essentially caused by gene mutations in TECs. Previous reports mostly described TECs as endothelial cells covering the inner surface of tumour blood vessels. Up to now, there is no clear definition of a group of cells as TECs. Based on this, we summarize the characteristics of TECs as follows. (1) They are derived from EPCs or tumour stem cells. (2) They have up‐regulation of glycolysis, mitochondrial respiration, and fatty acid metabolism. (3) They secrete different cytokines. (4) Some TECs highly express epidermal growth factor receptor and interleukin‐4 receptor. (5) They are distributed around or in tumours and play an important role in the processes of tumour growth, development, and metastasis.https://doi.org/10.1002/ctd2.36anti‐angiogenesis therapycytokinesgenesmetabolismnecroptosisnormal endothelial cells |
| spellingShingle | Linshan Xie Peipei Guo Meng Xiang Yuanlin Song Xiangdong Wang Charles A. Powell Chunxue Bai Dawei Yang Tumour endothelial cells for translational research and therapeutics Clinical and Translational Discovery anti‐angiogenesis therapy cytokines genes metabolism necroptosis normal endothelial cells |
| title | Tumour endothelial cells for translational research and therapeutics |
| title_full | Tumour endothelial cells for translational research and therapeutics |
| title_fullStr | Tumour endothelial cells for translational research and therapeutics |
| title_full_unstemmed | Tumour endothelial cells for translational research and therapeutics |
| title_short | Tumour endothelial cells for translational research and therapeutics |
| title_sort | tumour endothelial cells for translational research and therapeutics |
| topic | anti‐angiogenesis therapy cytokines genes metabolism necroptosis normal endothelial cells |
| url | https://doi.org/10.1002/ctd2.36 |
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