The association between serum adropin and carotid atherosclerosis in patients with type 2 diabetes mellitus: a cross‑sectional study
Abstract Background Adropin, a newly‑identified energy homeostasis protein, has been implicated in the maintenance of metabolic homeostasis and insulin sensitivity. This study attempts to measure the association between serum adropin and carotid atherosclerosis in patients with type 2 diabetes melli...
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13098-022-00796-y |
| _version_ | 1819274836671725568 |
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| author | Wen Wei Hui Liu Xiuping Qiu Jushun Zhang Jianqing Huang Hangju Chen Shuilin Qiu Ruiyu Lin Shihai Li Mei Tu |
| author_facet | Wen Wei Hui Liu Xiuping Qiu Jushun Zhang Jianqing Huang Hangju Chen Shuilin Qiu Ruiyu Lin Shihai Li Mei Tu |
| author_sort | Wen Wei |
| collection | DOAJ |
| description | Abstract Background Adropin, a newly‑identified energy homeostasis protein, has been implicated in the maintenance of metabolic homeostasis and insulin sensitivity. This study attempts to measure the association between serum adropin and carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Methods This cross‑sectional study was performed in 503 hospitalized patients with T2DM.Serum adropin level was measured by a sandwich enzyme-linked immunosorbent assay. The carotid atherosclerosis was assessed by color Doppler sonography. The association between adropin and carotid atherosclerotic plaque was tested by logistic regression model. The effect of adropin on carotid intimal-medial thickness (CIMT) was estimated using linear regression model. Results Overall, 280 (55.7%) patients had carotid atherosclerotic plaque. The risk of carotid atherosclerotic plaque decreased with the increment of serum adropin level (adjusted odds ratio [aOR], 0.90; 95%CI: 0.81–0.99) in patients with T2DM. Serum adropin (Standardized β = − 0.006, p = 0.028) was also independently protective factor for CIMT in patients with T2DM. Conclusion In patients with T2DM, high serum adropin level was correlated with a decreased risk of carotid atherosclerosis in T2DM patients. Low circulating level of adropin may promote carotid atherosclerosis. |
| first_indexed | 2024-12-23T23:14:46Z |
| format | Article |
| id | doaj.art-510b6e5ec5e24eec839409b3b7614972 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-12-23T23:14:46Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-510b6e5ec5e24eec839409b3b76149722022-12-21T17:26:31ZengBMCDiabetology & Metabolic Syndrome1758-59962022-02-011411810.1186/s13098-022-00796-yThe association between serum adropin and carotid atherosclerosis in patients with type 2 diabetes mellitus: a cross‑sectional studyWen Wei0Hui Liu1Xiuping Qiu2Jushun Zhang3Jianqing Huang4Hangju Chen5Shuilin Qiu6Ruiyu Lin7Shihai Li8Mei Tu9Department of Endocrinology, Fujian Longyan First Hospital, Longyan First Affiliated Hospital of Fujian Medical UniversityDepartment of Clinical Laboratory, Fujian Longyan First Hospital, Longyan First Affiliated Hospital of Fujian Medical UniversityDepartment of Endocrinology, Fujian Longyan First Hospital, Longyan First Affiliated Hospital of Fujian Medical UniversityDepartment of Endocrinology, Fujian Longyan First Hospital, Longyan First Affiliated Hospital of Fujian Medical UniversityDepartment of Endocrinology, Fujian Longyan First Hospital, Longyan First Affiliated Hospital of Fujian Medical UniversityDepartment of Endocrinology, Fujian Longyan First Hospital, Longyan First Affiliated Hospital of Fujian Medical UniversityDepartment of Endocrinology, Fujian Longyan First Hospital, Longyan First Affiliated Hospital of Fujian Medical UniversityDepartment of Endocrinology, Fujian Longyan First Hospital, Fujian Medical UniversityDepartment of Anesthesia, Fujian Longyan First Hospital, Longyan First Affiliated Hospital of Fujian Medical UniversityDepartment of Endocrinology, Fujian Longyan First Hospital, Longyan First Affiliated Hospital of Fujian Medical UniversityAbstract Background Adropin, a newly‑identified energy homeostasis protein, has been implicated in the maintenance of metabolic homeostasis and insulin sensitivity. This study attempts to measure the association between serum adropin and carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Methods This cross‑sectional study was performed in 503 hospitalized patients with T2DM.Serum adropin level was measured by a sandwich enzyme-linked immunosorbent assay. The carotid atherosclerosis was assessed by color Doppler sonography. The association between adropin and carotid atherosclerotic plaque was tested by logistic regression model. The effect of adropin on carotid intimal-medial thickness (CIMT) was estimated using linear regression model. Results Overall, 280 (55.7%) patients had carotid atherosclerotic plaque. The risk of carotid atherosclerotic plaque decreased with the increment of serum adropin level (adjusted odds ratio [aOR], 0.90; 95%CI: 0.81–0.99) in patients with T2DM. Serum adropin (Standardized β = − 0.006, p = 0.028) was also independently protective factor for CIMT in patients with T2DM. Conclusion In patients with T2DM, high serum adropin level was correlated with a decreased risk of carotid atherosclerosis in T2DM patients. Low circulating level of adropin may promote carotid atherosclerosis.https://doi.org/10.1186/s13098-022-00796-yAdropinCarotid atherosclerosisType 2 diabetes mellitus |
| spellingShingle | Wen Wei Hui Liu Xiuping Qiu Jushun Zhang Jianqing Huang Hangju Chen Shuilin Qiu Ruiyu Lin Shihai Li Mei Tu The association between serum adropin and carotid atherosclerosis in patients with type 2 diabetes mellitus: a cross‑sectional study Diabetology & Metabolic Syndrome Adropin Carotid atherosclerosis Type 2 diabetes mellitus |
| title | The association between serum adropin and carotid atherosclerosis in patients with type 2 diabetes mellitus: a cross‑sectional study |
| title_full | The association between serum adropin and carotid atherosclerosis in patients with type 2 diabetes mellitus: a cross‑sectional study |
| title_fullStr | The association between serum adropin and carotid atherosclerosis in patients with type 2 diabetes mellitus: a cross‑sectional study |
| title_full_unstemmed | The association between serum adropin and carotid atherosclerosis in patients with type 2 diabetes mellitus: a cross‑sectional study |
| title_short | The association between serum adropin and carotid atherosclerosis in patients with type 2 diabetes mellitus: a cross‑sectional study |
| title_sort | association between serum adropin and carotid atherosclerosis in patients with type 2 diabetes mellitus a cross sectional study |
| topic | Adropin Carotid atherosclerosis Type 2 diabetes mellitus |
| url | https://doi.org/10.1186/s13098-022-00796-y |
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