Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort
Abstract The authors sought to characterize adverse posttraumatic neuropsychiatric sequelae (APNS) symptom trajectories across ten symptom domains (pain, depression, sleep, nightmares, avoidance, re-experiencing, anxiety, hyperarousal, somatic, and mental/fatigue symptoms) in a large, diverse, under...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-01-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-022-02289-y |
| _version_ | 1797958475361288192 |
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| author | Francesca L. Beaudoin Xinming An Archana Basu Yinyao Ji Mochuan Liu Ronald C. Kessler Robert F. Doughtery Donglin Zeng Kenneth A. Bollen Stacey L. House Jennifer S. Stevens Thomas C. Neylan Gari D. Clifford Tanja Jovanovic Sarah D. Linnstaedt Laura T. Germine Scott L. Rauch John P. Haran Alan B. Storrow Christopher Lewandowski Paul I. Musey Phyllis L. Hendry Sophia Sheikh Christopher W. Jones Brittany E. Punches Michael C. Kurz Robert A. Swor Vishnu P. Murty Meghan E. McGrath Lauren A. Hudak Jose L. Pascual Elizabeth M. Datner Anna M. Chang Claire Pearson David A. Peak Roland C. Merchant Robert M. Domeier Niels K. Rathlev Brian J. O’ Neil Paulina Sergot Leon D. Sanchez Steven E. Bruce Justin T. Baker Jutta Joormann Mark W. Miller Robert H. Pietrzak Deanna M. Barch Diego A. Pizzagalli John F. Sheridan Jordan W. Smoller Steven E. Harte James M. Elliott Karestan C. Koenen Kerry J. Ressler Samuel A. McLean |
| author_facet | Francesca L. Beaudoin Xinming An Archana Basu Yinyao Ji Mochuan Liu Ronald C. Kessler Robert F. Doughtery Donglin Zeng Kenneth A. Bollen Stacey L. House Jennifer S. Stevens Thomas C. Neylan Gari D. Clifford Tanja Jovanovic Sarah D. Linnstaedt Laura T. Germine Scott L. Rauch John P. Haran Alan B. Storrow Christopher Lewandowski Paul I. Musey Phyllis L. Hendry Sophia Sheikh Christopher W. Jones Brittany E. Punches Michael C. Kurz Robert A. Swor Vishnu P. Murty Meghan E. McGrath Lauren A. Hudak Jose L. Pascual Elizabeth M. Datner Anna M. Chang Claire Pearson David A. Peak Roland C. Merchant Robert M. Domeier Niels K. Rathlev Brian J. O’ Neil Paulina Sergot Leon D. Sanchez Steven E. Bruce Justin T. Baker Jutta Joormann Mark W. Miller Robert H. Pietrzak Deanna M. Barch Diego A. Pizzagalli John F. Sheridan Jordan W. Smoller Steven E. Harte James M. Elliott Karestan C. Koenen Kerry J. Ressler Samuel A. McLean |
| author_sort | Francesca L. Beaudoin |
| collection | DOAJ |
| description | Abstract The authors sought to characterize adverse posttraumatic neuropsychiatric sequelae (APNS) symptom trajectories across ten symptom domains (pain, depression, sleep, nightmares, avoidance, re-experiencing, anxiety, hyperarousal, somatic, and mental/fatigue symptoms) in a large, diverse, understudied sample of motor vehicle collision (MVC) survivors. More than two thousand MVC survivors were enrolled in the emergency department (ED) and completed a rotating battery of brief smartphone-based surveys over a 2-month period. Measurement models developed from survey item responses were used in latent growth curve/mixture modeling to characterize homogeneous symptom trajectories. Associations between individual trajectories and pre-trauma and peritraumatic characteristics and traditional outcomes were compared, along with associations within and between trajectories. APNS across all ten symptom domains were common in the first two months after trauma. Many risk factors and associations with high symptom burden trajectories were shared across domains. Both across and within traditional diagnostic boundaries, APNS trajectory intercepts, and slopes were substantially correlated. Across all domains, symptom severity in the immediate aftermath of trauma (trajectory intercepts) had the greatest influence on the outcome. An interactive data visualization tool was developed to allow readers to explore relationships of interest between individual characteristics, symptom trajectories, and traditional outcomes ( http://itr.med.unc.edu/aurora/parcoord/ ). Individuals presenting to the ED after MVC commonly experience a broad constellation of adverse posttraumatic symptoms. Many risk factors for diverse APNS are shared. Individuals diagnosed with a single traditional outcome should be screened for others. The utility of multidimensional categorizations that characterize individuals across traditional diagnostic domains should be explored. |
| first_indexed | 2024-04-11T00:19:34Z |
| format | Article |
| id | doaj.art-510c0dddcb9f404fb719cf4b5ffda57e |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-04-11T00:19:34Z |
| publishDate | 2023-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-510c0dddcb9f404fb719cf4b5ffda57e2023-01-08T12:21:29ZengNature Publishing GroupTranslational Psychiatry2158-31882023-01-0113111110.1038/s41398-022-02289-yUse of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohortFrancesca L. Beaudoin0Xinming An1Archana Basu2Yinyao Ji3Mochuan Liu4Ronald C. Kessler5Robert F. Doughtery6Donglin Zeng7Kenneth A. Bollen8Stacey L. House9Jennifer S. Stevens10Thomas C. Neylan11Gari D. Clifford12Tanja Jovanovic13Sarah D. Linnstaedt14Laura T. Germine15Scott L. Rauch16John P. Haran17Alan B. Storrow18Christopher Lewandowski19Paul I. Musey20Phyllis L. Hendry21Sophia Sheikh22Christopher W. Jones23Brittany E. Punches24Michael C. Kurz25Robert A. Swor26Vishnu P. Murty27Meghan E. McGrath28Lauren A. Hudak29Jose L. Pascual30Elizabeth M. Datner31Anna M. Chang32Claire Pearson33David A. Peak34Roland C. Merchant35Robert M. Domeier36Niels K. Rathlev37Brian J. O’ Neil38Paulina Sergot39Leon D. Sanchez40Steven E. Bruce41Justin T. Baker42Jutta Joormann43Mark W. Miller44Robert H. Pietrzak45Deanna M. Barch46Diego A. Pizzagalli47John F. Sheridan48Jordan W. Smoller49Steven E. Harte50James M. Elliott51Karestan C. Koenen52Kerry J. Ressler53Samuel A. McLean54Department of Epidemiology, Brown UniversityInstitute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel HillDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard UniversityInstitute for Trauma Recovery, Department of Psychiatry, University of North Carolina at Chapel HillInstitute for Trauma Recovery, Department of Psychiatry, University of North Carolina at Chapel HillDepartment of Health Care Policy, Harvard Medical SchoolMindstrong HealthDepartment of Biostatistics, Gillings School of Global Public Health, University of North CarolinaDepartment of Psychology and Neuroscience & Department of Sociology, University of North Carolina at Chapel HillDepartment of Emergency Medicine, Washington University School of MedicineDepartment of Psychiatry and Behavioral Sciences, Emory University School of MedicineDepartments of Psychiatry and Neurology, University of California San FranciscoDepartment of Biomedical Informatics, Emory University School of MedicineDepartment of Psychiatry and Behavioral Neurosciences, Wayne State UniversityInstitute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel HillInstitute for Technology in Psychiatry, McLean HospitalInstitute for Technology in Psychiatry, McLean HospitalDepartment of Emergency Medicine, University of Massachusetts Medical SchoolDepartment of Emergency Medicine, Vanderbilt University Medical CenterDepartment of Emergency Medicine, Henry Ford Health SystemDepartment of Emergency Medicine, Indiana University School of MedicineDepartment of Emergency Medicine, University of Florida College of Medicine -JacksonvilleDepartment of Emergency Medicine, University of Florida College of Medicine -JacksonvilleDepartment of Emergency Medicine, Cooper Medical School of Rowan UniversityDepartment of Emergency Medicine, University of Cincinnati College of MedicineDepartment of Emergency Medicine, University of Alabama School of MedicineDepartment of Emergency Medicine, Oakland University William Beaumont School of MedicineDepartment of Psychology, Temple UniversityDepartment of Emergency Medicine, Boston Medical CenterDepartment of Emergency Medicine, Emory University School of MedicineDepartment of Surgery, Department of Neurosurgery, University of PennsylvaniaDepartment of Emergency Medicine, Einstein Healthcare NetworkDepartment of Emergency Medicine, Jefferson University HospitalsDepartment of Emergency Medicine, Wayne State UniversityDepartment of Emergency Medicine, Massachusetts General HospitalDepartment of Emergency Medicine, Brigham and Women’s HospitalDepartment of Emergency Medicine, Saint Joseph Mercy HospitalDepartment of Emergency Medicine, University of Massachusetts Medical School-BaystateDepartment of Emergency Medicine, Wayne State UniversityDepartment of Emergency Medicine, McGovern Medical School, University of Texas HealthDepartment of Emergency Medicine, Beth Israel Deaconess Medical CenterDepartment of Psychological Sciences, University of Missouri - St. LouisMindstrong HealthDepartment of Psychology, Yale UniversityNational Center for PTSD, Behavioral Science Division, VA Boston Healthcare SystemNational Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare SystemDepartment of Psychological & Brain Sciences, Washington University in St. LouisDepartment of Psychiatry, Harvard Medical SchoolDepartment of Biosciences, OSU Wexner Medical CenterDepartment of Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General HospitalDepartment of Anesthesiology, University of Michigan Medical SchoolKolling Institute of Medical Research, University of SydneyDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard UniversityDepartment of Psychiatry, Harvard Medical SchoolInstitute for Trauma Recovery, Department of Psychiatry, University of North Carolina at Chapel HillAbstract The authors sought to characterize adverse posttraumatic neuropsychiatric sequelae (APNS) symptom trajectories across ten symptom domains (pain, depression, sleep, nightmares, avoidance, re-experiencing, anxiety, hyperarousal, somatic, and mental/fatigue symptoms) in a large, diverse, understudied sample of motor vehicle collision (MVC) survivors. More than two thousand MVC survivors were enrolled in the emergency department (ED) and completed a rotating battery of brief smartphone-based surveys over a 2-month period. Measurement models developed from survey item responses were used in latent growth curve/mixture modeling to characterize homogeneous symptom trajectories. Associations between individual trajectories and pre-trauma and peritraumatic characteristics and traditional outcomes were compared, along with associations within and between trajectories. APNS across all ten symptom domains were common in the first two months after trauma. Many risk factors and associations with high symptom burden trajectories were shared across domains. Both across and within traditional diagnostic boundaries, APNS trajectory intercepts, and slopes were substantially correlated. Across all domains, symptom severity in the immediate aftermath of trauma (trajectory intercepts) had the greatest influence on the outcome. An interactive data visualization tool was developed to allow readers to explore relationships of interest between individual characteristics, symptom trajectories, and traditional outcomes ( http://itr.med.unc.edu/aurora/parcoord/ ). Individuals presenting to the ED after MVC commonly experience a broad constellation of adverse posttraumatic symptoms. Many risk factors for diverse APNS are shared. Individuals diagnosed with a single traditional outcome should be screened for others. The utility of multidimensional categorizations that characterize individuals across traditional diagnostic domains should be explored.https://doi.org/10.1038/s41398-022-02289-y |
| spellingShingle | Francesca L. Beaudoin Xinming An Archana Basu Yinyao Ji Mochuan Liu Ronald C. Kessler Robert F. Doughtery Donglin Zeng Kenneth A. Bollen Stacey L. House Jennifer S. Stevens Thomas C. Neylan Gari D. Clifford Tanja Jovanovic Sarah D. Linnstaedt Laura T. Germine Scott L. Rauch John P. Haran Alan B. Storrow Christopher Lewandowski Paul I. Musey Phyllis L. Hendry Sophia Sheikh Christopher W. Jones Brittany E. Punches Michael C. Kurz Robert A. Swor Vishnu P. Murty Meghan E. McGrath Lauren A. Hudak Jose L. Pascual Elizabeth M. Datner Anna M. Chang Claire Pearson David A. Peak Roland C. Merchant Robert M. Domeier Niels K. Rathlev Brian J. O’ Neil Paulina Sergot Leon D. Sanchez Steven E. Bruce Justin T. Baker Jutta Joormann Mark W. Miller Robert H. Pietrzak Deanna M. Barch Diego A. Pizzagalli John F. Sheridan Jordan W. Smoller Steven E. Harte James M. Elliott Karestan C. Koenen Kerry J. Ressler Samuel A. McLean Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort Translational Psychiatry |
| title | Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort |
| title_full | Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort |
| title_fullStr | Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort |
| title_full_unstemmed | Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort |
| title_short | Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort |
| title_sort | use of serial smartphone based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort |
| url | https://doi.org/10.1038/s41398-022-02289-y |
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