Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma Treatment

Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma Treatment

Current systemic treatment options for patients with adrenocortical carcinomas (ACCs) are far from being satisfactory. DNA damage/repair mechanisms, which involve, e.g., ataxia-telangiectasia-mutated (ATM) and ataxia-telangiectasia/Rad3-related (ATR) protein signaling or ribonucleotide reductase sub...

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Bibliographic Details
Main Authors: Christina Bothou, Ashish Sharma, Adrian Oo, Baek Kim, Pal Perge, Peter Igaz, Cristina L. Ronchi, Igor Shapiro, Constanze Hantel
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
adrenocortical carcinoma
adrenocortical cell line
RRM2
RNR
COH29
Online Access:https://www.mdpi.com/2072-6694/13/16/4200

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