Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks.

Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks.

RAD18 is an ubiquitin ligase involved in replicative damage bypass and DNA double-strand break (DSB) repair processes. We found that RPA is required for the dynamic pattern of RAD18 localization during the cell cycle, and for accumulation of RAD18 at sites of γ-irradiation-induced DNA damage. In add...

Full description

Bibliographic Details
Main Authors: Akiko Inagaki, Esther Sleddens-Linkels, Wiggert A van Cappellen, Richard G Hibbert, Titia K Sixma, Jan H J Hoeijmakers, J Anton Grootegoed, Willy M Baarends
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3157352?pdf=render

Similar Items

Similar Items