Comparative physicochemical investigation of the inclusion compounds of cyclodextrins with arginine and histidine stereoisomers
The inclusion complexes of α-, β-cyclodextrin and 2-hydroxypropyl-α-cyclodextrin with two amino acid stereoisomers (L-, D-arginine and L-, D-histidine) were studied by using differential scanning calorimetry, thermogravimetry, Fourier transform infrared spectroscopy, and scanning electron microscop...
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| Format: | Article |
| Language: | English |
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Society of Chemists and Technologists of Macedonia
2024-04-01
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| Series: | Macedonian Journal of Chemistry and Chemical Engineering |
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| Online Access: | https://mjcce.org.mk/index.php/MJCCE/article/view/2757 |
| _version_ | 1797200959248531456 |
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| author | Andreea Neacsu |
| author_facet | Andreea Neacsu |
| author_sort | Andreea Neacsu |
| collection | DOAJ |
| description |
The inclusion complexes of α-, β-cyclodextrin and 2-hydroxypropyl-α-cyclodextrin with two amino acid stereoisomers (L-, D-arginine and L-, D-histidine) were studied by using differential scanning calorimetry, thermogravimetry, Fourier transform infrared spectroscopy, and scanning electron microscopy methods. The solid inclusion compounds were prepared in a 1:1 molar ratio of the host and guest using the co-precipitation method. The pH measurements and structural visualization of complexes were carried out. The obtained results proved the formation of the complexes and revealed that the size and the symmetry of the cyclodextrin (CD) and also the structure and flexibility of the amino acid molecule had a significant influence on the complexation interaction. The correlation of the experimental data shows that βCD has a preference to form more stable complexes with levogir isomers of amino acid than αCD and 2-hydroxypropyl-α-cyclodextrin. The complexation of the amino acids isomers was accomplished by partial inclusion of the guest molecule in the CD cavity, and it was observed that CDs could better discriminate between histidine isomers than between arginine isomers.
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| first_indexed | 2024-04-24T07:39:56Z |
| format | Article |
| id | doaj.art-510f04f947964dbca02f9d03f4b431fb |
| institution | Directory Open Access Journal |
| issn | 1857-5552 1857-5625 |
| language | English |
| last_indexed | 2024-04-24T07:39:56Z |
| publishDate | 2024-04-01 |
| publisher | Society of Chemists and Technologists of Macedonia |
| record_format | Article |
| series | Macedonian Journal of Chemistry and Chemical Engineering |
| spelling | doaj.art-510f04f947964dbca02f9d03f4b431fb2024-04-20T03:17:43ZengSociety of Chemists and Technologists of MacedoniaMacedonian Journal of Chemistry and Chemical Engineering1857-55521857-56252024-04-0143110.20450/mjcce.2024.2757Comparative physicochemical investigation of the inclusion compounds of cyclodextrins with arginine and histidine stereoisomersAndreea Neacsu0Institute of Physical Chemistry "Ilie Murgulescu" of the Romanian Academy, Bucharest The inclusion complexes of α-, β-cyclodextrin and 2-hydroxypropyl-α-cyclodextrin with two amino acid stereoisomers (L-, D-arginine and L-, D-histidine) were studied by using differential scanning calorimetry, thermogravimetry, Fourier transform infrared spectroscopy, and scanning electron microscopy methods. The solid inclusion compounds were prepared in a 1:1 molar ratio of the host and guest using the co-precipitation method. The pH measurements and structural visualization of complexes were carried out. The obtained results proved the formation of the complexes and revealed that the size and the symmetry of the cyclodextrin (CD) and also the structure and flexibility of the amino acid molecule had a significant influence on the complexation interaction. The correlation of the experimental data shows that βCD has a preference to form more stable complexes with levogir isomers of amino acid than αCD and 2-hydroxypropyl-α-cyclodextrin. The complexation of the amino acids isomers was accomplished by partial inclusion of the guest molecule in the CD cavity, and it was observed that CDs could better discriminate between histidine isomers than between arginine isomers. https://mjcce.org.mk/index.php/MJCCE/article/view/2757cyclodextrinhistidinearginineinclusion complexthermal |
| spellingShingle | Andreea Neacsu Comparative physicochemical investigation of the inclusion compounds of cyclodextrins with arginine and histidine stereoisomers Macedonian Journal of Chemistry and Chemical Engineering cyclodextrin histidine arginine inclusion complex thermal |
| title | Comparative physicochemical investigation of the inclusion compounds of cyclodextrins with arginine and histidine stereoisomers |
| title_full | Comparative physicochemical investigation of the inclusion compounds of cyclodextrins with arginine and histidine stereoisomers |
| title_fullStr | Comparative physicochemical investigation of the inclusion compounds of cyclodextrins with arginine and histidine stereoisomers |
| title_full_unstemmed | Comparative physicochemical investigation of the inclusion compounds of cyclodextrins with arginine and histidine stereoisomers |
| title_short | Comparative physicochemical investigation of the inclusion compounds of cyclodextrins with arginine and histidine stereoisomers |
| title_sort | comparative physicochemical investigation of the inclusion compounds of cyclodextrins with arginine and histidine stereoisomers |
| topic | cyclodextrin histidine arginine inclusion complex thermal |
| url | https://mjcce.org.mk/index.php/MJCCE/article/view/2757 |
| work_keys_str_mv | AT andreeaneacsu comparativephysicochemicalinvestigationoftheinclusioncompoundsofcyclodextrinswitharginineandhistidinestereoisomers |