The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants, and antipsychotics for the human α1A, α1B, and α1D‐adrenoceptors

The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants, and antipsychotics for the human α1A, α1B, and α1D‐adrenoceptors

Abstract α1‐adrenoceptor antagonists are widely used for hypertension (eg, doxazosin) and benign prostatic hypertrophy (BPH, eg, tamsulosin). Some antidepressants and antipsychotics have been reported to have α1 affinity. This study examined 101 clinical drugs and laboratory compounds to build a com...

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Bibliographic Details
Main Authors: Richard G. W. Proudman, Andre S. Pupo, Jillian G. Baker
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Pharmacology Research & Perspectives
Subjects:
affinity
antidepressant
antipsychotic
benign prostatic hypertrophy
hypertension
α antagonist
Online Access:https://doi.org/10.1002/prp2.602

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