Survival, Recurrence, and Clinicopathological Characteristics in Multifocal and/or Multicentric versus Unifocal Locoregional Breast Cancers: Results of a Large Breast Cancer Registry
Background: Much is still unknown regarding the clinicopathology and prognosis of patients with multifocal/multicentric breast cancer (MMBC). We herein compared the clinicopathology and prognosis of patients with unifocal and MMBCs.Method: This cross-sectional research is a part of Shiraz Breast Can...
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Format: | Article |
Language: | English |
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Shiraz University of Medical Sciences
2023-01-01
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Series: | Middle East Journal of Cancer |
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Online Access: | https://mejc.sums.ac.ir/article_48768_9f31187a18df19ffb51e4b14b6f3f317.pdf |
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author | Mojtaba Omidvar Sedigheh Tahmasebi Majid Akrami Payam Arasteh Vahid Zangouri Akbar Safaei Sara Hosseini Aida Salehi Nobandegani Seyed Morteza Hosseini Abdolrasoul Talei |
author_facet | Mojtaba Omidvar Sedigheh Tahmasebi Majid Akrami Payam Arasteh Vahid Zangouri Akbar Safaei Sara Hosseini Aida Salehi Nobandegani Seyed Morteza Hosseini Abdolrasoul Talei |
author_sort | Mojtaba Omidvar |
collection | DOAJ |
description | Background: Much is still unknown regarding the clinicopathology and prognosis of patients with multifocal/multicentric breast cancer (MMBC). We herein compared the clinicopathology and prognosis of patients with unifocal and MMBCs.Method: This cross-sectional research is a part of Shiraz Breast Cancer Registry (SBCR). We studied all the patients in the SBCR (n=6145). Ultrasound reports were used to differentiate between MMBCs and unifocal breast cancers (BCs). All the patients were examined with mammography and the diagnosis was confirmed postoperatively via pathology reports.Results: After exclusion, 4045 patients entered the study (n=1072 and n=2973 for multifocal/multicentric and unifocal BCs, respectively). The mean follow-up period was 57.9 (0.27-275) months. Patients with MMBCs had higher rates of mastectomy (48% vs. 40.1%; P < 0.001) and higher rates of HER-2 overexpression (32.1% vs. 26%; P = 0.001) compared with those with unifocal BCs. Tumor size, lymph node involvement, type of axillary management, chemotherapy, radiotherapy, hormonal therapy, recurrence rates, histological grade, lymphovascular invasion, axillary node involvement, estrogen and progesterone receptor expression status, tumor, node, and metastasis staging were not significantly different between the groups. Five-year overall survival was 88.3% and 89% (P = 0.8) for unifocal and MMBCs, respectively; moreover, five-year disease-free survival was 80.2% and 81.2% (P = 0.41), respectively.Conclusion: Despite the controversy regarding prognosis and surgical management in MMBCs, we found that MMBCs had similar clinicopathological features and prognosis compared to unifocal BCs. Survival, recurrence, and metastasis were similar among the two groups. |
first_indexed | 2024-04-11T04:56:25Z |
format | Article |
id | doaj.art-5110c4081b3745a49e07025e0c357168 |
institution | Directory Open Access Journal |
issn | 2008-6709 2008-6687 |
language | English |
last_indexed | 2024-04-11T04:56:25Z |
publishDate | 2023-01-01 |
publisher | Shiraz University of Medical Sciences |
record_format | Article |
series | Middle East Journal of Cancer |
spelling | doaj.art-5110c4081b3745a49e07025e0c3571682022-12-26T09:11:34ZengShiraz University of Medical SciencesMiddle East Journal of Cancer2008-67092008-66872023-01-0114111912610.30476/mejc.2022.92135.164748768Survival, Recurrence, and Clinicopathological Characteristics in Multifocal and/or Multicentric versus Unifocal Locoregional Breast Cancers: Results of a Large Breast Cancer RegistryMojtaba Omidvar0Sedigheh Tahmasebi1Majid Akrami2Payam Arasteh3Vahid Zangouri4Akbar Safaei5Sara Hosseini6Aida Salehi Nobandegani7Seyed Morteza Hosseini8Abdolrasoul Talei9Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, IranBreast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, IranBreast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, IranBreast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, IranBreast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pathology, Shiraz University of Medical Sciences, Shiraz, IranBreast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, IranBreast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, IranNon-communicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, IranBreast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, IranBackground: Much is still unknown regarding the clinicopathology and prognosis of patients with multifocal/multicentric breast cancer (MMBC). We herein compared the clinicopathology and prognosis of patients with unifocal and MMBCs.Method: This cross-sectional research is a part of Shiraz Breast Cancer Registry (SBCR). We studied all the patients in the SBCR (n=6145). Ultrasound reports were used to differentiate between MMBCs and unifocal breast cancers (BCs). All the patients were examined with mammography and the diagnosis was confirmed postoperatively via pathology reports.Results: After exclusion, 4045 patients entered the study (n=1072 and n=2973 for multifocal/multicentric and unifocal BCs, respectively). The mean follow-up period was 57.9 (0.27-275) months. Patients with MMBCs had higher rates of mastectomy (48% vs. 40.1%; P < 0.001) and higher rates of HER-2 overexpression (32.1% vs. 26%; P = 0.001) compared with those with unifocal BCs. Tumor size, lymph node involvement, type of axillary management, chemotherapy, radiotherapy, hormonal therapy, recurrence rates, histological grade, lymphovascular invasion, axillary node involvement, estrogen and progesterone receptor expression status, tumor, node, and metastasis staging were not significantly different between the groups. Five-year overall survival was 88.3% and 89% (P = 0.8) for unifocal and MMBCs, respectively; moreover, five-year disease-free survival was 80.2% and 81.2% (P = 0.41), respectively.Conclusion: Despite the controversy regarding prognosis and surgical management in MMBCs, we found that MMBCs had similar clinicopathological features and prognosis compared to unifocal BCs. Survival, recurrence, and metastasis were similar among the two groups.https://mejc.sums.ac.ir/article_48768_9f31187a18df19ffb51e4b14b6f3f317.pdfbreast neoplasmstagingsurvivalmulticentricitymultifocality |
spellingShingle | Mojtaba Omidvar Sedigheh Tahmasebi Majid Akrami Payam Arasteh Vahid Zangouri Akbar Safaei Sara Hosseini Aida Salehi Nobandegani Seyed Morteza Hosseini Abdolrasoul Talei Survival, Recurrence, and Clinicopathological Characteristics in Multifocal and/or Multicentric versus Unifocal Locoregional Breast Cancers: Results of a Large Breast Cancer Registry Middle East Journal of Cancer breast neoplasm staging survival multicentricity multifocality |
title | Survival, Recurrence, and Clinicopathological Characteristics in Multifocal and/or Multicentric versus Unifocal Locoregional Breast Cancers: Results of a Large Breast Cancer Registry |
title_full | Survival, Recurrence, and Clinicopathological Characteristics in Multifocal and/or Multicentric versus Unifocal Locoregional Breast Cancers: Results of a Large Breast Cancer Registry |
title_fullStr | Survival, Recurrence, and Clinicopathological Characteristics in Multifocal and/or Multicentric versus Unifocal Locoregional Breast Cancers: Results of a Large Breast Cancer Registry |
title_full_unstemmed | Survival, Recurrence, and Clinicopathological Characteristics in Multifocal and/or Multicentric versus Unifocal Locoregional Breast Cancers: Results of a Large Breast Cancer Registry |
title_short | Survival, Recurrence, and Clinicopathological Characteristics in Multifocal and/or Multicentric versus Unifocal Locoregional Breast Cancers: Results of a Large Breast Cancer Registry |
title_sort | survival recurrence and clinicopathological characteristics in multifocal and or multicentric versus unifocal locoregional breast cancers results of a large breast cancer registry |
topic | breast neoplasm staging survival multicentricity multifocality |
url | https://mejc.sums.ac.ir/article_48768_9f31187a18df19ffb51e4b14b6f3f317.pdf |
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