A Review of the Genetic Diversity and Immune Escape of SARS-CoV-2
Background & aim: SARS-CoV-2 virus expresses specific patterns of genetic diversity in the genome. These changes in the virus and its genetic diversity in human populations can determine the transmission of the virus and the severity of the Covid-19 disease. Genetic diversity and immune differen...
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| Format: | Article |
| Language: | fas |
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Yasuj University Of Medical Sciences
2022-08-01
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| Series: | Armaghane Danesh Bimonthly Journal |
| Subjects: | |
| Online Access: | http://armaghanj.yums.ac.ir/article-1-3302-en.pdf |
| _version_ | 1797662121255763968 |
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| author | K Mobarki Dil V Tahmasebi A Hadinia F Hadinia |
| author_facet | K Mobarki Dil V Tahmasebi A Hadinia F Hadinia |
| author_sort | K Mobarki Dil |
| collection | DOAJ |
| description | Background & aim: SARS-CoV-2 virus expresses specific patterns of genetic diversity in the genome. These changes in the virus and its genetic diversity in human populations can determine the transmission of the virus and the severity of the Covid-19 disease. Genetic diversity and immune differences in human populations can be the driving force in the evolution of the virus and its escape from the immune system. The aim of the present study was to investigate the genetic changes and escape routes of the SARS-CoV-2 virus from immune responses.
Methods: In this review article conducted in 2021 at Yasuj University of Medical Sciences, studies published in electronic databases; Pub-Med, Science Direct, Elsevier, Scopus and Google Scholar were investigated regarding the genetic diversity of the SARS-CoV-2 virus and its ways of escaping the immune system.
Results: The results indicated that various mutations have been observed in SARS-CoV-2 virus types, some of these mutations are effective on viral characteristics such as infection and severity of the covid-19 disease and are related to the ability to escape from immune responses and can lead to inhibition of innate immune responses. and be acquired.
Conclusion: By identifying the types of mutations of SARS-CoV-2 virus and their relationship with the ways of escaping from the immune system, we can hope for effective treatment methods as well as obtaining vaccines with greater efficiency and effectiveness. |
| first_indexed | 2024-03-11T18:55:30Z |
| format | Article |
| id | doaj.art-511384177b6c497c935794681e375404 |
| institution | Directory Open Access Journal |
| issn | 1728-6506 1728-6514 |
| language | fas |
| last_indexed | 2024-03-11T18:55:30Z |
| publishDate | 2022-08-01 |
| publisher | Yasuj University Of Medical Sciences |
| record_format | Article |
| series | Armaghane Danesh Bimonthly Journal |
| spelling | doaj.art-511384177b6c497c935794681e3754042023-10-11T04:43:16ZfasYasuj University Of Medical SciencesArmaghane Danesh Bimonthly Journal1728-65061728-65142022-08-01275637650A Review of the Genetic Diversity and Immune Escape of SARS-CoV-2K Mobarki Dil0V Tahmasebi1A Hadinia2F Hadinia3 Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran Department of Bacteriology & Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Background & aim: SARS-CoV-2 virus expresses specific patterns of genetic diversity in the genome. These changes in the virus and its genetic diversity in human populations can determine the transmission of the virus and the severity of the Covid-19 disease. Genetic diversity and immune differences in human populations can be the driving force in the evolution of the virus and its escape from the immune system. The aim of the present study was to investigate the genetic changes and escape routes of the SARS-CoV-2 virus from immune responses. Methods: In this review article conducted in 2021 at Yasuj University of Medical Sciences, studies published in electronic databases; Pub-Med, Science Direct, Elsevier, Scopus and Google Scholar were investigated regarding the genetic diversity of the SARS-CoV-2 virus and its ways of escaping the immune system. Results: The results indicated that various mutations have been observed in SARS-CoV-2 virus types, some of these mutations are effective on viral characteristics such as infection and severity of the covid-19 disease and are related to the ability to escape from immune responses and can lead to inhibition of innate immune responses. and be acquired. Conclusion: By identifying the types of mutations of SARS-CoV-2 virus and their relationship with the ways of escaping from the immune system, we can hope for effective treatment methods as well as obtaining vaccines with greater efficiency and effectiveness.http://armaghanj.yums.ac.ir/article-1-3302-en.pdfcovid-19genetic diversityimmune system |
| spellingShingle | K Mobarki Dil V Tahmasebi A Hadinia F Hadinia A Review of the Genetic Diversity and Immune Escape of SARS-CoV-2 Armaghane Danesh Bimonthly Journal covid-19 genetic diversity immune system |
| title | A Review of the Genetic Diversity and Immune Escape of SARS-CoV-2 |
| title_full | A Review of the Genetic Diversity and Immune Escape of SARS-CoV-2 |
| title_fullStr | A Review of the Genetic Diversity and Immune Escape of SARS-CoV-2 |
| title_full_unstemmed | A Review of the Genetic Diversity and Immune Escape of SARS-CoV-2 |
| title_short | A Review of the Genetic Diversity and Immune Escape of SARS-CoV-2 |
| title_sort | review of the genetic diversity and immune escape of sars cov 2 |
| topic | covid-19 genetic diversity immune system |
| url | http://armaghanj.yums.ac.ir/article-1-3302-en.pdf |
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