Galectins: a key intersection between glycobiology and immunology
Galectins are a family of evolutionarily conserved animal lectins, widely distributed from lower invertebrates to mammals. They share sequence and structure similarities in the carbohydrate recognition domain and specificity for polylactosamine-enriched glycoconjugates. In the last few years signifi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Divulgação Científica
1999-04-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000400002 |
| _version_ | 1819264427965284352 |
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| author | G.A. Rabinovich C.M. Riera C.A. Landa C.E. Sotomayor |
| author_facet | G.A. Rabinovich C.M. Riera C.A. Landa C.E. Sotomayor |
| author_sort | G.A. Rabinovich |
| collection | DOAJ |
| description | Galectins are a family of evolutionarily conserved animal lectins, widely distributed from lower invertebrates to mammals. They share sequence and structure similarities in the carbohydrate recognition domain and specificity for polylactosamine-enriched glycoconjugates. In the last few years significant experimental data have been accumulated concerning their participation in different biological processes requiring carbohydrate recognition such as cell adhesion, cell growth regulation, inflammation, immunomodulation, apoptosis and metastasis. In the present review we will discuss some exciting questions and advances in galectin research, highlighting the significance of these proteins in immunological processes and their implications in biomedical research, disease diagnosis and clinical intervention. Designing novel therapeutic strategies based on carbohydrate recognition will provide answers for the treatment of autoimmune disorders, inflammatory processes, allergic reactions and tumor spreading. |
| first_indexed | 2024-12-23T20:29:19Z |
| format | Article |
| id | doaj.art-51150a5d61c749aa871e80cccde89ae8 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-23T20:29:19Z |
| publishDate | 1999-04-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-51150a5d61c749aa871e80cccde89ae82022-12-21T17:32:16ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X1999-04-0132438310.1590/S0100-879X1999000400002Galectins: a key intersection between glycobiology and immunologyG.A. RabinovichC.M. RieraC.A. LandaC.E. SotomayorGalectins are a family of evolutionarily conserved animal lectins, widely distributed from lower invertebrates to mammals. They share sequence and structure similarities in the carbohydrate recognition domain and specificity for polylactosamine-enriched glycoconjugates. In the last few years significant experimental data have been accumulated concerning their participation in different biological processes requiring carbohydrate recognition such as cell adhesion, cell growth regulation, inflammation, immunomodulation, apoptosis and metastasis. In the present review we will discuss some exciting questions and advances in galectin research, highlighting the significance of these proteins in immunological processes and their implications in biomedical research, disease diagnosis and clinical intervention. Designing novel therapeutic strategies based on carbohydrate recognition will provide answers for the treatment of autoimmune disorders, inflammatory processes, allergic reactions and tumor spreading.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000400002galectinsimmunomodulationapoptosisadhesionembryogenesismetastasis |
| spellingShingle | G.A. Rabinovich C.M. Riera C.A. Landa C.E. Sotomayor Galectins: a key intersection between glycobiology and immunology Brazilian Journal of Medical and Biological Research galectins immunomodulation apoptosis adhesion embryogenesis metastasis |
| title | Galectins: a key intersection between glycobiology and immunology |
| title_full | Galectins: a key intersection between glycobiology and immunology |
| title_fullStr | Galectins: a key intersection between glycobiology and immunology |
| title_full_unstemmed | Galectins: a key intersection between glycobiology and immunology |
| title_short | Galectins: a key intersection between glycobiology and immunology |
| title_sort | galectins a key intersection between glycobiology and immunology |
| topic | galectins immunomodulation apoptosis adhesion embryogenesis metastasis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000400002 |
| work_keys_str_mv | AT garabinovich galectinsakeyintersectionbetweenglycobiologyandimmunology AT cmriera galectinsakeyintersectionbetweenglycobiologyandimmunology AT calanda galectinsakeyintersectionbetweenglycobiologyandimmunology AT cesotomayor galectinsakeyintersectionbetweenglycobiologyandimmunology |