Targeting the PAI-1 Mechanism with a Small Peptide Increases the Efficacy of Alteplase in a Rabbit Model of Chronic Empyema

Targeting the PAI-1 Mechanism with a Small Peptide Increases the Efficacy of Alteplase in a Rabbit Model of Chronic Empyema

The incidence of empyema is increasing and associated with a mortality rate of 20% in patients older than 65 years. Since 30% of patients with advanced empyema have contraindications to surgical treatment, novel, low-dose, pharmacological treatments are needed. A <i>Streptococcus pneumoniae<...

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Bibliographic Details
Main Authors: Galina Florova, Christian J. De Vera, Rebekah L. Emerine, René A. Girard, Ali O. Azghani, Krishna Sarva, Jincy Jacob, Danna E. Morris, Mignote Chamiso, Steven Idell, Andrey A. Komissarov
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Pharmaceutics
Subjects:
PAI-1
serpin
empyema
chronic
molecular target
preclinical
Online Access:https://www.mdpi.com/1999-4923/15/5/1498

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