The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells

The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells

Abstract Background Testicular germ cell cancer (TGCC) develops from pre-malignant germ neoplasia in situ (GCNIS) cells. GCNIS originates from fetal gonocytes (POU5F1+/MAGE-A4−), which fail to differentiate to pre-spermatogonia (POU5F1−/MAGE-A4+) and undergo malignant transformation. Gankyrin is an...

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Bibliographic Details
Main Authors: Maria E. Camacho-Moll, Joni Macdonald, L. H. J. Looijenga, Michael P. Rimmer, Roland Donat, John A. Marwick, C. J. Shukla, Neil Carragher, Anne Jørgensen, Rod T. Mitchell
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Cancer
Subjects:
Gankyrin
Testicular germ cell cancer
GCNIS
Apoptosis
Cisplatin sensitivity
Online Access:http://link.springer.com/article/10.1186/s12885-019-6340-7

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