PINK1 protects against dendritic cell dysfunction during sepsis through the regulation of mitochondrial quality control

PINK1 protects against dendritic cell dysfunction during sepsis through the regulation of mitochondrial quality control

Abstract Background Dendritic cell (DC) dysfunction plays a central role in sepsis-induced immunosuppression. Recent research has indicated that collective mitochondrial fragmentation contributes to the dysfunction of immune cells observed during sepsis. PTEN-induced putative kinase 1 (PINK1) has be...

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Bibliographic Details
Main Authors: You Wu, Longwang Chen, Zhimin Qiu, Xijing Zhang, Guangju Zhao, Zhongqiu Lu
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Molecular Medicine
Subjects:
Sepsis
Dendritic cells
PINK1
Mitophagy
Mitochondrial fission
Mitochondrial quality control
Online Access:https://doi.org/10.1186/s10020-023-00618-5

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