Global burden, risk factors, and trends of non‐Hodgkin lymphoma: A worldwide analysis of cancer registries
Abstract Background Non‐Hodgkin lymphoma (NHL) accounts for 90% of all malignant lymphomas. This study aimed to evaluate the global incidence, mortality, associated risk factors, and temporal trends of NHL by sex, age, and country. Methods Data from 185 countries globally were used for analysis. NHL...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-03-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.7056 |
| _version_ | 1797246027462344704 |
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| author | Junjie Huang Sze Chai Chan Veeleah Lok Lin Zhang Don Eliseo Lucero‐Prisno III Wanghong Xu Zhi‐Jie Zheng Edmar Elcarte Mellissa Withers Martin C. S. Wong |
| author_facet | Junjie Huang Sze Chai Chan Veeleah Lok Lin Zhang Don Eliseo Lucero‐Prisno III Wanghong Xu Zhi‐Jie Zheng Edmar Elcarte Mellissa Withers Martin C. S. Wong |
| author_sort | Junjie Huang |
| collection | DOAJ |
| description | Abstract Background Non‐Hodgkin lymphoma (NHL) accounts for 90% of all malignant lymphomas. This study aimed to evaluate the global incidence, mortality, associated risk factors, and temporal trends of NHL by sex, age, and country. Methods Data from 185 countries globally were used for analysis. NHL incidence and mortality were collected via the GLOBOCAN (2020), CI5 series I‐X, WHO mortality database, the Nordic Cancer Registries, and the SEER Program. The WHO Global Health Observatory provided country‐level, age‐standardized prevalence of lifestyle and metabolic risk factors. Trends were examined and reported based on average annual percentage change (AAPC) calculated using Joinpoint regression analysis. Incidence and AAPC are based on data for the last 10 years across countries. Results Globally, age‐standardized incidence and mortality rates for NHL were recorded at 5.8 and 2.6 per 100,000 individuals, respectively. At country‐level, NHL incidence was significantly associated with various factors, including HDI (Human Development Index), GDP per capita, prevalence of tobacco and alcohol consumption, sedentary lifestyle, obesity, hypertension, diabetes and hypercholesterolaemia. Rising trend in NHL incidence was observed, with the highest increase recorded in Estonia (AAPCmale = 4.15, AAPCfemale = 5.14), Belarus (AAPCfemale = 5.13), and Lithuania (AAPCfemale = 4.68). While overall NHL mortality has been decreasing, certain populations experienced increased mortality over the decade. In Thailand, AAPC for mortality was 31.28% for males and 30.26% for females. Estonia saw an AAPC of 6.46% for males, while Slovakia experienced an AAPC of 4.24% for females. Colombia's AAPC was 1.29% for males and 1.51% for females. Conclusions This study indicates a rising trend of NHL incidence over the past decade‐ particularly in developed countries, older males, and younger populations. Further research should investigate deeper insights into specific etiology and prognosis of NHL across subtypes, and potential contributors towards these epidemiologic trends. |
| first_indexed | 2024-04-24T19:36:16Z |
| format | Article |
| id | doaj.art-5119a5c3bd1441719e54673fb86f3c10 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-24T19:36:16Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-5119a5c3bd1441719e54673fb86f3c102024-03-25T13:10:39ZengWileyCancer Medicine2045-76342024-03-01135n/an/a10.1002/cam4.7056Global burden, risk factors, and trends of non‐Hodgkin lymphoma: A worldwide analysis of cancer registriesJunjie Huang0Sze Chai Chan1Veeleah Lok2Lin Zhang3Don Eliseo Lucero‐Prisno III4Wanghong Xu5Zhi‐Jie Zheng6Edmar Elcarte7Mellissa Withers8Martin C. S. Wong9The Jockey Club School of Public Health and Primary Care, Faculty of Medicine Chinese University of Hong Kong Hong Kong SAR ChinaThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine Chinese University of Hong Kong Hong Kong SAR ChinaDepartment of Global Public Health Karolinska Institute, Karolinska University Hospital Stockholm SwedenSuzhou Industrial Park Monash Research Institute of Science and Technology Suzhou ChinaDepartment of Global Health and Development London School of Hygiene and Tropical Medicine London UKSchool of Public Health Fudan University Shanghai ChinaDepartment of Global Health, School of Public Health Peking University Beijing ChinaUniversity of the Philippines Manila PhilippinesDepartment of Population and Health Sciences, Institute for Global Health University of Southern California Los Angeles California USAThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine Chinese University of Hong Kong Hong Kong SAR ChinaAbstract Background Non‐Hodgkin lymphoma (NHL) accounts for 90% of all malignant lymphomas. This study aimed to evaluate the global incidence, mortality, associated risk factors, and temporal trends of NHL by sex, age, and country. Methods Data from 185 countries globally were used for analysis. NHL incidence and mortality were collected via the GLOBOCAN (2020), CI5 series I‐X, WHO mortality database, the Nordic Cancer Registries, and the SEER Program. The WHO Global Health Observatory provided country‐level, age‐standardized prevalence of lifestyle and metabolic risk factors. Trends were examined and reported based on average annual percentage change (AAPC) calculated using Joinpoint regression analysis. Incidence and AAPC are based on data for the last 10 years across countries. Results Globally, age‐standardized incidence and mortality rates for NHL were recorded at 5.8 and 2.6 per 100,000 individuals, respectively. At country‐level, NHL incidence was significantly associated with various factors, including HDI (Human Development Index), GDP per capita, prevalence of tobacco and alcohol consumption, sedentary lifestyle, obesity, hypertension, diabetes and hypercholesterolaemia. Rising trend in NHL incidence was observed, with the highest increase recorded in Estonia (AAPCmale = 4.15, AAPCfemale = 5.14), Belarus (AAPCfemale = 5.13), and Lithuania (AAPCfemale = 4.68). While overall NHL mortality has been decreasing, certain populations experienced increased mortality over the decade. In Thailand, AAPC for mortality was 31.28% for males and 30.26% for females. Estonia saw an AAPC of 6.46% for males, while Slovakia experienced an AAPC of 4.24% for females. Colombia's AAPC was 1.29% for males and 1.51% for females. Conclusions This study indicates a rising trend of NHL incidence over the past decade‐ particularly in developed countries, older males, and younger populations. Further research should investigate deeper insights into specific etiology and prognosis of NHL across subtypes, and potential contributors towards these epidemiologic trends.https://doi.org/10.1002/cam4.7056incidencemortalitynon‐Hodgkin lymphomarisk factorstemporal trends |
| spellingShingle | Junjie Huang Sze Chai Chan Veeleah Lok Lin Zhang Don Eliseo Lucero‐Prisno III Wanghong Xu Zhi‐Jie Zheng Edmar Elcarte Mellissa Withers Martin C. S. Wong Global burden, risk factors, and trends of non‐Hodgkin lymphoma: A worldwide analysis of cancer registries Cancer Medicine incidence mortality non‐Hodgkin lymphoma risk factors temporal trends |
| title | Global burden, risk factors, and trends of non‐Hodgkin lymphoma: A worldwide analysis of cancer registries |
| title_full | Global burden, risk factors, and trends of non‐Hodgkin lymphoma: A worldwide analysis of cancer registries |
| title_fullStr | Global burden, risk factors, and trends of non‐Hodgkin lymphoma: A worldwide analysis of cancer registries |
| title_full_unstemmed | Global burden, risk factors, and trends of non‐Hodgkin lymphoma: A worldwide analysis of cancer registries |
| title_short | Global burden, risk factors, and trends of non‐Hodgkin lymphoma: A worldwide analysis of cancer registries |
| title_sort | global burden risk factors and trends of non hodgkin lymphoma a worldwide analysis of cancer registries |
| topic | incidence mortality non‐Hodgkin lymphoma risk factors temporal trends |
| url | https://doi.org/10.1002/cam4.7056 |
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