Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients
There are few data on the longitudinal association of cytokine and appetite among older hospitalized patients. We aimed to investigate the impact of the changes of inflammatory cytokines on appetite in older hospitalized patients. A total of 191 patients (mean age 81.3 ± 6.6 years, 64% women) partic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/8/2508 |
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| author | Maryam Pourhassan Nina Babel Lars Sieske Timm Henning Westhoff Rainer Wirth |
| author_facet | Maryam Pourhassan Nina Babel Lars Sieske Timm Henning Westhoff Rainer Wirth |
| author_sort | Maryam Pourhassan |
| collection | DOAJ |
| description | There are few data on the longitudinal association of cytokine and appetite among older hospitalized patients. We aimed to investigate the impact of the changes of inflammatory cytokines on appetite in older hospitalized patients. A total of 191 patients (mean age 81.3 ± 6.6 years, 64% women) participated in this prospective longitudinal observational study. Appetite was evaluated using the Edmonton Symptom Assessment System on admission and after seven days. Serum cytokines such as IL-1β, IL-6, IL-8, IL-10, IL-12p70, IL-17, IL-18, IL-23 and IL-33, IFN-α2, IFN-γ, TNF-α and MCP-1 were measured both times. No significant differences in the mean serum levels of all the cytokines could be detected overtime in relation to appetite changes, except for IL-18. Appetite significantly deteriorated overtime in patients with increasing IL-18 levels and improved in those without significant changes in IL-18 levels. In a stepwise regression analysis, changes of IL-18 levels were the major independent predictor for the changes of patients’ appetite and explained 4% of the variance, whereas other cytokines and variables, such as age, sex, infection and disease, did not show any impact on appetite changes. We conclude that IL-18 seems to exert a significant impact on appetite in acutely ill older hospitalized patients and should, therefore, be considered as a potential target in the diagnosis, prevention and treatment of malnutrition. |
| first_indexed | 2024-03-10T08:31:08Z |
| format | Article |
| id | doaj.art-511aa082a79742359304cc803e7f4549 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T08:31:08Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-511aa082a79742359304cc803e7f45492023-11-22T09:01:45ZengMDPI AGNutrients2072-66432021-07-01138250810.3390/nu13082508Longitudinal Changes of Cytokines and Appetite in Older Hospitalized PatientsMaryam Pourhassan0Nina Babel1Lars Sieske2Timm Henning Westhoff3Rainer Wirth4Department of Geriatric Medicine, Marien Hospital Herne, Ruhr-Universität Bochum, Hölkeskampring 40D, 44625 Herne, GermanyMedical Department I, General Internal Medicine, Marien Hospital Herne, Ruhr-Universität Bochum, 44625 Herne, GermanyDepartment of Geriatric Medicine, Marien Hospital Herne, Ruhr-Universität Bochum, Hölkeskampring 40D, 44625 Herne, GermanyMedical Department I, General Internal Medicine, Marien Hospital Herne, Ruhr-Universität Bochum, 44625 Herne, GermanyDepartment of Geriatric Medicine, Marien Hospital Herne, Ruhr-Universität Bochum, Hölkeskampring 40D, 44625 Herne, GermanyThere are few data on the longitudinal association of cytokine and appetite among older hospitalized patients. We aimed to investigate the impact of the changes of inflammatory cytokines on appetite in older hospitalized patients. A total of 191 patients (mean age 81.3 ± 6.6 years, 64% women) participated in this prospective longitudinal observational study. Appetite was evaluated using the Edmonton Symptom Assessment System on admission and after seven days. Serum cytokines such as IL-1β, IL-6, IL-8, IL-10, IL-12p70, IL-17, IL-18, IL-23 and IL-33, IFN-α2, IFN-γ, TNF-α and MCP-1 were measured both times. No significant differences in the mean serum levels of all the cytokines could be detected overtime in relation to appetite changes, except for IL-18. Appetite significantly deteriorated overtime in patients with increasing IL-18 levels and improved in those without significant changes in IL-18 levels. In a stepwise regression analysis, changes of IL-18 levels were the major independent predictor for the changes of patients’ appetite and explained 4% of the variance, whereas other cytokines and variables, such as age, sex, infection and disease, did not show any impact on appetite changes. We conclude that IL-18 seems to exert a significant impact on appetite in acutely ill older hospitalized patients and should, therefore, be considered as a potential target in the diagnosis, prevention and treatment of malnutrition.https://www.mdpi.com/2072-6643/13/8/2508appetitecytokinesinflammationinterleukin-18older persons |
| spellingShingle | Maryam Pourhassan Nina Babel Lars Sieske Timm Henning Westhoff Rainer Wirth Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients Nutrients appetite cytokines inflammation interleukin-18 older persons |
| title | Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients |
| title_full | Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients |
| title_fullStr | Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients |
| title_full_unstemmed | Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients |
| title_short | Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients |
| title_sort | longitudinal changes of cytokines and appetite in older hospitalized patients |
| topic | appetite cytokines inflammation interleukin-18 older persons |
| url | https://www.mdpi.com/2072-6643/13/8/2508 |
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