Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei

Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei

We have discovered a new mechanism of monoallelic gene expression that links antigenic variation, cell cycle, and development in the model parasite Trypanosoma brucei. African trypanosomes possess hundreds of variant surface glycoprotein (VSG) genes, but only one is expressed from a telomeric expres...

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Bibliographic Details
Main Authors:	Christopher Batram, Nicola G Jones, Christian J Janzen, Sebastian M Markert, Markus Engstler
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2014-05-01
Series:	eLife
Subjects:	Trypanosoma brucei variant surface glycoprotein monoallelic expression antigenic variation expression site attenuation developmental reprogramming
Online Access:	https://elifesciences.org/articles/02324

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