Mesoporous Silica Nanoparticle–Based Combination of NQO1 Inhibitor and 5-Fluorouracil for Potent Antitumor Effect Against Head and Neck Squamous Cell Carcinoma (HNSCC)

Mesoporous Silica Nanoparticle–Based Combination of NQO1 Inhibitor and 5-Fluorouracil for Potent Antitumor Effect Against Head and Neck Squamous Cell Carcinoma (HNSCC)

Abstract Head and neck squamous cell carcinomas (HNSCC) are one of the deadliest forms of cancer, and 90% of its origin is from squamous cells. NAD(P)H:quinone oxidoreductase 1 (NQO1), an enzyme overexpressed in squamous cell carcinoma, plays an important role in proliferation and chemoresistance. T...

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Bibliographic Details
Main Authors: Jing Chen, Shuzhen Zhang, Shuai Zhang, Shanjun Gao, Jianbo Wang, Dongchun Lei, Pengqiang Du, Zhiwei Xu, Cailiang Zhu, Hongbin Sun
Format: Article
Language:English
Published: SpringerOpen 2019-12-01
Series:Nanoscale Research Letters
Subjects:
Squamous cell carcinoma
NQO1 inhibitor
Lipid bilayer
Mesoporous silica nanoparticles
Apoptosis
Online Access:https://doi.org/10.1186/s11671-019-3224-3

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