Mitigating sarcoplasmic reticulum stress limits disuse-induced muscle loss in hindlimb unloaded mice

Mitigating sarcoplasmic reticulum stress limits disuse-induced muscle loss in hindlimb unloaded mice

Abstract Muscle disuse in the hindlimb unloaded (HU) mice causes significant atrophy and weakness. However, the cellular and molecular mechanisms driving disuse-muscle atrophy remain elusive. We investigated the potential contribution of proteins dysregulation by sarcoplasmic reticulum (SR), a condi...

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Bibliographic Details
Main Authors: Amir Ali Khan, Muhammad Tehsil Gul, Asima Karim, Anu Ranade, Muhammad Azeem, Zeinab Ibrahim, Gopika Ramachandran, Vidhya A. Nair, Firdos Ahmad, Adel Elmoselhi, Rizwan Qaisar
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:npj Microgravity
Online Access:https://doi.org/10.1038/s41526-022-00211-w

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