RTA404, an Activator of Nrf2, Activates the Checkpoint Kinases and Induces Apoptosis through Intrinsic Apoptotic Pathway in Malignant Glioma

RTA404, an Activator of Nrf2, Activates the Checkpoint Kinases and Induces Apoptosis through Intrinsic Apoptotic Pathway in Malignant Glioma

<b>Background:</b> Malignant glioma (MG) is an aggressive malignant brain tumor. Despite advances in multidisciplinary treatment, overall survival rates remain low. A trifluoroethyl amide derivative of 2-cyano-3-,12-dioxoolean-1,9-dien-28-oic acid (CDDO), CDDO–trifluoroethyl amide (CDDO–...

Full description

Bibliographic Details
Main Authors: Tai-Hsin Tsai, Ann-Shung Lieu, Tzuu-Yuan Huang, Aij-Lie Kwan, Chih-Lung Lin, Yi-Chiang Hsu
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Journal of Clinical Medicine
Subjects:
RTA404
malignant glioma
apoptosis
checkpoint kinase
Online Access:https://www.mdpi.com/2077-0383/10/21/4805

Internet

https://www.mdpi.com/2077-0383/10/21/4805

Similar Items