Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus

Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus

Abstract Background Iron deficiency (ID) during the fetal-neonatal period results in long-term neurodevelopmental impairments associated with pervasive hippocampal gene dysregulation. Prenatal choline supplementation partially normalizes these effects, suggesting an interaction between iron and chol...

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Bibliographic Details
Main Authors: Shirelle X. Liu, Aarthi Ramakrishnan, Li Shen, Jonathan C. Gewirtz, Michael K. Georgieff, Phu V. Tran
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Genomics
Subjects:
Iron deficiency
Choline
Chromatin accessibility
H3K9me3 ChIP-seq
Hippocampus
Epigenetics
Online Access:https://doi.org/10.1186/s12864-024-10230-4

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