Structural and Computational Study of the GroEL–Prion Protein Complex

Structural and Computational Study of the GroEL–Prion Protein Complex

The molecular chaperone GroEL is designed to promote protein folding and prevent aggregation. However, the interaction between GroEL and the prion protein, PrP<sup>C</sup>, could lead to pathogenic transformation of the latter to the aggregation-prone PrP<sup>Sc</sup> form. H...

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Bibliographic Details
Main Authors: Aleksandra A. Mamchur, Andrei V. Moiseenko, Irina S. Panina, Igor A. Yaroshevich, Sofia S. Kudryavtseva, Evgeny B. Pichkur, Olga S. Sokolova, Vladimir I. Muronetz, Tatiana B. Stanishneva-Konovalova
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Biomedicines
Subjects:
molecular chaperones
GroEL
prion protein
Cryo-EM
molecular dynamics
Online Access:https://www.mdpi.com/2227-9059/9/11/1649

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