IL-21–producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts

IL-21–producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts

Follicular helper T (Tfh) cells have been implicated in controlling rejection after allogeneic kidney transplantation, but the precise subsets, origins, and functions of Tfh cells in this process have not been fully characterized. Here we show that a subset of effector Tfh cells marked by previous I...

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Bibliographic Details
Main Authors: Hengcheng Zhang, Cecilia B. Cavazzoni, Manuel A. Podestà, Elsa D. Bechu, Garyfallia Ralli, Pragya Chandrakar, Jeong-Mi Lee, Ismail Sayin, Stefan G. Tullius, Reza Abdi, Anita S. Chong, Bruce R. Blazar, Peter T. Sage
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-10-01
Series:JCI Insight
Subjects:
Immunology
Transplantation
Online Access:https://doi.org/10.1172/jci.insight.169793

Internet

https://doi.org/10.1172/jci.insight.169793

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