Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients
Liver biopsy is the gold-standard method to stage fibrosis; however, it is an invasive procedure and is potentially dangerous. The main objective of this study was to evaluate biological markers, such as cytokines IL-13, IFN-γ, TNF-α and TGF-β, platelets, bilirubins (Bil),...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2010-07-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400018 |
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| author | Clarice Neuenschwander Lins de Morais Bruno de Melo Carvalho Wlademir Gomes de Melo Fábio Lopes de Melo Edmundo Pessoa de Almeida Lopes Ana Lúcia Coutinho Domingues Norma Jucá João Roberto Maciel Martins George Tadeu Nunes Diniz Silvia Maria Lucena Montenegro |
| author_facet | Clarice Neuenschwander Lins de Morais Bruno de Melo Carvalho Wlademir Gomes de Melo Fábio Lopes de Melo Edmundo Pessoa de Almeida Lopes Ana Lúcia Coutinho Domingues Norma Jucá João Roberto Maciel Martins George Tadeu Nunes Diniz Silvia Maria Lucena Montenegro |
| author_sort | Clarice Neuenschwander Lins de Morais |
| collection | DOAJ |
| description | Liver biopsy is the gold-standard method to stage fibrosis; however, it is an invasive procedure and is potentially dangerous. The main objective of this study was to evaluate biological markers, such as cytokines IL-13, IFN-γ, TNF-α and TGF-β, platelets, bilirubins (Bil), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), total proteins, γ-glutamil transferase (γ-GT) and alkaline phosphatase (AP), that could be used to predict the severity of hepatic fibrosis in schistosomiasis and hepatitis C (HC) as isolated diseases or co-infections. The following patient groups were selected: HC (n = 39), HC/hepatosplenic schistosomiasis (HSS) (n = 19), HSS (n = 22) and a control group (n = 13). ANOVA and ROC curves were used for statistical analysis. P < 0.05 was considered significant. With HC patients we showed that TNF-α (p = 0.020) and AP (p = 0.005) could differentiate mild and severe fibrosis. With regard to necroinflammatory activity, AST (p = 0.002), γ-GT (p = 0.034) and AP (p = 0.001) were the best markers to differentiate mild and severe activity. In HC + HSS patients, total Bil (p = 0.008) was capable of differentiating between mild and severe fibrosis. In conclusion, our study was able to suggest biological markers that are non-invasive candidates to evaluate fibrosis and necroinflammatory activity in HC and HC + HSS. |
| first_indexed | 2024-03-12T08:10:39Z |
| format | Article |
| id | doaj.art-512386021856452194821dffff85c988 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:10:39Z |
| publishDate | 2010-07-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-512386021856452194821dffff85c9882023-09-02T19:07:04ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602010-07-01105446046610.1590/S0074-02762010000400018Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patientsClarice Neuenschwander Lins de MoraisBruno de Melo CarvalhoWlademir Gomes de MeloFábio Lopes de MeloEdmundo Pessoa de Almeida LopesAna Lúcia Coutinho DominguesNorma JucáJoão Roberto Maciel MartinsGeorge Tadeu Nunes DinizSilvia Maria Lucena MontenegroLiver biopsy is the gold-standard method to stage fibrosis; however, it is an invasive procedure and is potentially dangerous. The main objective of this study was to evaluate biological markers, such as cytokines IL-13, IFN-γ, TNF-α and TGF-β, platelets, bilirubins (Bil), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), total proteins, γ-glutamil transferase (γ-GT) and alkaline phosphatase (AP), that could be used to predict the severity of hepatic fibrosis in schistosomiasis and hepatitis C (HC) as isolated diseases or co-infections. The following patient groups were selected: HC (n = 39), HC/hepatosplenic schistosomiasis (HSS) (n = 19), HSS (n = 22) and a control group (n = 13). ANOVA and ROC curves were used for statistical analysis. P < 0.05 was considered significant. With HC patients we showed that TNF-α (p = 0.020) and AP (p = 0.005) could differentiate mild and severe fibrosis. With regard to necroinflammatory activity, AST (p = 0.002), γ-GT (p = 0.034) and AP (p = 0.001) were the best markers to differentiate mild and severe activity. In HC + HSS patients, total Bil (p = 0.008) was capable of differentiating between mild and severe fibrosis. In conclusion, our study was able to suggest biological markers that are non-invasive candidates to evaluate fibrosis and necroinflammatory activity in HC and HC + HSS.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400018biological markershepatic fibrosisHCschistosomiasis |
| spellingShingle | Clarice Neuenschwander Lins de Morais Bruno de Melo Carvalho Wlademir Gomes de Melo Fábio Lopes de Melo Edmundo Pessoa de Almeida Lopes Ana Lúcia Coutinho Domingues Norma Jucá João Roberto Maciel Martins George Tadeu Nunes Diniz Silvia Maria Lucena Montenegro Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients Memorias do Instituto Oswaldo Cruz biological markers hepatic fibrosis HC schistosomiasis |
| title | Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients |
| title_full | Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients |
| title_fullStr | Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients |
| title_full_unstemmed | Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients |
| title_short | Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients |
| title_sort | correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis c and schistosomiasis patients |
| topic | biological markers hepatic fibrosis HC schistosomiasis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400018 |
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