Erythrocyte Sedimentation Rate: Its Determinants and Relationship with Risk Factors Involved in Ischemic Stroke
Erythrocyte sedimentation rate (ESR) evaluation is a useful tool for monitoring disease activity in various inflammatory and non-inflammatory conditions. ESR is known to be influenced by a multitude of confounding factors. The present study aimed to assess the possible determinants of the ESR and...
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| Format: | Article |
| Language: | English |
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The Korean Society for Clinical Laboratory Science
2022-03-01
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| Series: | Korean Journal of Clinical Laboratory Science |
| Subjects: |
| _version_ | 1818286886363332608 |
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| author | Kirandeep Kaur Amandeep Kaur Anupam Kaur |
| author_facet | Kirandeep Kaur Amandeep Kaur Anupam Kaur |
| author_sort | Kirandeep Kaur |
| collection | DOAJ |
| description | Erythrocyte sedimentation rate (ESR) evaluation is a useful tool for monitoring disease activity in
various inflammatory and non-inflammatory conditions. ESR is known to be influenced by a
multitude of confounding factors. The present study aimed to assess the possible determinants of
the ESR and its relationship with various risk factors involved in ischemic stroke. ESR and other
hematological and biochemical parameters were investigated in 163 ischemic stroke patients (107
males and 56 females) selected based on imaging techniques including magnetic resonance imaging
(MRI) or computed tomography (CT) scans. Statistical analysis was performed using the SPSS 16.0
software. Linear regression analysis showed a significant inverse relationship of hemoglobin (Hb)
and hematocrit or packed cell volume (PCV) (P＜0.001 for females; P＜0.01 for males) with the ESR.
It was observed that the red blood cell (RBC) count was not strongly correlated with the ESR (P＜0.05
for both males and females). It was also observed that sex significantly affected the variables
determining the ESR levels, whereas age had no effect. Gender differences were also observed with
respect to Hb, RBC, PCV, mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin
concentration (MCHC), and ESR. The possible determinants of higher ESR levels in ischemic stroke
may be sex, Hb, hematocrit, and RBC count, but the role of other clinical and laboratory parameters
cannot be underestimated. |
| first_indexed | 2024-12-13T01:31:43Z |
| format | Article |
| id | doaj.art-5127f2e5fc6945408b3e6e6a0627a9f5 |
| institution | Directory Open Access Journal |
| issn | 1738-3544 2288-1662 |
| language | English |
| last_indexed | 2024-12-13T01:31:43Z |
| publishDate | 2022-03-01 |
| publisher | The Korean Society for Clinical Laboratory Science |
| record_format | Article |
| series | Korean Journal of Clinical Laboratory Science |
| spelling | doaj.art-5127f2e5fc6945408b3e6e6a0627a9f52022-12-22T00:03:59ZengThe Korean Society for Clinical Laboratory ScienceKorean Journal of Clinical Laboratory Science1738-35442288-16622022-03-015411810.15324/kjcls.2022.54.1.1Erythrocyte Sedimentation Rate: Its Determinants and Relationship with Risk Factors Involved in Ischemic StrokeKirandeep Kaur0Amandeep Kaur1Anupam Kaur2https://orcid.org/0000-0002-2010-1234Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab IndiaDepartment of Viral Research and Diagnostic Laboratory, Amritsar, Punjab IndiaDepartment of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab IndiaErythrocyte sedimentation rate (ESR) evaluation is a useful tool for monitoring disease activity in various inflammatory and non-inflammatory conditions. ESR is known to be influenced by a multitude of confounding factors. The present study aimed to assess the possible determinants of the ESR and its relationship with various risk factors involved in ischemic stroke. ESR and other hematological and biochemical parameters were investigated in 163 ischemic stroke patients (107 males and 56 females) selected based on imaging techniques including magnetic resonance imaging (MRI) or computed tomography (CT) scans. Statistical analysis was performed using the SPSS 16.0 software. Linear regression analysis showed a significant inverse relationship of hemoglobin (Hb) and hematocrit or packed cell volume (PCV) (P＜0.001 for females; P＜0.01 for males) with the ESR. It was observed that the red blood cell (RBC) count was not strongly correlated with the ESR (P＜0.05 for both males and females). It was also observed that sex significantly affected the variables determining the ESR levels, whereas age had no effect. Gender differences were also observed with respect to Hb, RBC, PCV, mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and ESR. The possible determinants of higher ESR levels in ischemic stroke may be sex, Hb, hematocrit, and RBC count, but the role of other clinical and laboratory parameters cannot be underestimated.erythrocyte sedimentation ratehematologyinflammationischemic stroke |
| spellingShingle | Kirandeep Kaur Amandeep Kaur Anupam Kaur Erythrocyte Sedimentation Rate: Its Determinants and Relationship with Risk Factors Involved in Ischemic Stroke Korean Journal of Clinical Laboratory Science erythrocyte sedimentation rate hematology inflammation ischemic stroke |
| title | Erythrocyte Sedimentation Rate: Its Determinants and Relationship with Risk Factors Involved in Ischemic Stroke |
| title_full | Erythrocyte Sedimentation Rate: Its Determinants and Relationship with Risk Factors Involved in Ischemic Stroke |
| title_fullStr | Erythrocyte Sedimentation Rate: Its Determinants and Relationship with Risk Factors Involved in Ischemic Stroke |
| title_full_unstemmed | Erythrocyte Sedimentation Rate: Its Determinants and Relationship with Risk Factors Involved in Ischemic Stroke |
| title_short | Erythrocyte Sedimentation Rate: Its Determinants and Relationship with Risk Factors Involved in Ischemic Stroke |
| title_sort | erythrocyte sedimentation rate its determinants and relationship with risk factors involved in ischemic stroke |
| topic | erythrocyte sedimentation rate hematology inflammation ischemic stroke |
| work_keys_str_mv | AT kirandeepkaur erythrocytesedimentationrateitsdeterminantsandrelationshipwithriskfactorsinvolvedinischemicstroke AT amandeepkaur erythrocytesedimentationrateitsdeterminantsandrelationshipwithriskfactorsinvolvedinischemicstroke AT anupamkaur erythrocytesedimentationrateitsdeterminantsandrelationshipwithriskfactorsinvolvedinischemicstroke |