Mechanical Thrombectomy in Cerebral Venous Sinus Thrombosis: Reports of a Retrospective Single-Center Study
Current standard care for acute cerebral venous sinus thrombosis (CVST) includes either intravenous heparin or subcutaneous low-molecular-weight heparin, but patients with refractory CVST, despite adequate anticoagulation therapy, may benefit from mechanical thrombectomy (MT). A retrospective study...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/21/6381 |
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| author | Farzaneh Jedi Gero Dethlefs Till-Karsten Hauser Florian Hennersdorf Annerose Mengel Ulrike Ernemann Benjamin Bender |
| author_facet | Farzaneh Jedi Gero Dethlefs Till-Karsten Hauser Florian Hennersdorf Annerose Mengel Ulrike Ernemann Benjamin Bender |
| author_sort | Farzaneh Jedi |
| collection | DOAJ |
| description | Current standard care for acute cerebral venous sinus thrombosis (CVST) includes either intravenous heparin or subcutaneous low-molecular-weight heparin, but patients with refractory CVST, despite adequate anticoagulation therapy, may benefit from mechanical thrombectomy (MT). A retrospective study of patients with CVST, who underwent MT between 2011 and 2019, was performed looking at procedure success rate and clinical outcomes. Two raters evaluated the cerebral venous system of every patient before and after the intervention using the following scoring system: (0) No obvious thrombosis; (1) thrombosis without impaired blood flow; (2) thrombosis with impaired blood flow; (3) and thrombosis with complete vascular occlusion. The success of MT was measured using a score quotient (Q = A/B), dividing the sum of the patient’s scores after the intervention (A) by the sum of scores before the intervention (B). Overall, 21 MTs were performed on 20 patients with refractory or severe CVST. Clinical improvement was seen in 61.9% during hospital stay and in 80% at 6-month follow-up, with complete recovery in 70% of patients. Patients with favorable outcomes had significantly lower recanalization quotients (<i>p</i> = 0.008). Our study provides evidence supporting that MT may be a safe and effective treatment with favorable clinical outcomes for selected patients with CVST. |
| first_indexed | 2024-03-09T18:57:35Z |
| format | Article |
| id | doaj.art-5128257ad8c24bedaa66d8f758b5c0fb |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T18:57:35Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-5128257ad8c24bedaa66d8f758b5c0fb2023-11-24T05:16:45ZengMDPI AGJournal of Clinical Medicine2077-03832022-10-011121638110.3390/jcm11216381Mechanical Thrombectomy in Cerebral Venous Sinus Thrombosis: Reports of a Retrospective Single-Center StudyFarzaneh Jedi0Gero Dethlefs1Till-Karsten Hauser2Florian Hennersdorf3Annerose Mengel4Ulrike Ernemann5Benjamin Bender6Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, 72076 Tübingen, GermanyDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, 72076 Tübingen, GermanyDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, 72076 Tübingen, GermanyDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, 72076 Tübingen, GermanyDepartment of Neurology and Stroke, Hertie-Institute for Clinical Brain Research, University Hospital Tübingen, 72076 Tübingen, GermanyDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, 72076 Tübingen, GermanyDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, 72076 Tübingen, GermanyCurrent standard care for acute cerebral venous sinus thrombosis (CVST) includes either intravenous heparin or subcutaneous low-molecular-weight heparin, but patients with refractory CVST, despite adequate anticoagulation therapy, may benefit from mechanical thrombectomy (MT). A retrospective study of patients with CVST, who underwent MT between 2011 and 2019, was performed looking at procedure success rate and clinical outcomes. Two raters evaluated the cerebral venous system of every patient before and after the intervention using the following scoring system: (0) No obvious thrombosis; (1) thrombosis without impaired blood flow; (2) thrombosis with impaired blood flow; (3) and thrombosis with complete vascular occlusion. The success of MT was measured using a score quotient (Q = A/B), dividing the sum of the patient’s scores after the intervention (A) by the sum of scores before the intervention (B). Overall, 21 MTs were performed on 20 patients with refractory or severe CVST. Clinical improvement was seen in 61.9% during hospital stay and in 80% at 6-month follow-up, with complete recovery in 70% of patients. Patients with favorable outcomes had significantly lower recanalization quotients (<i>p</i> = 0.008). Our study provides evidence supporting that MT may be a safe and effective treatment with favorable clinical outcomes for selected patients with CVST.https://www.mdpi.com/2077-0383/11/21/6381cerebral venous sinus thrombosismechanical thrombectomyendovascular therapythrombolysis |
| spellingShingle | Farzaneh Jedi Gero Dethlefs Till-Karsten Hauser Florian Hennersdorf Annerose Mengel Ulrike Ernemann Benjamin Bender Mechanical Thrombectomy in Cerebral Venous Sinus Thrombosis: Reports of a Retrospective Single-Center Study Journal of Clinical Medicine cerebral venous sinus thrombosis mechanical thrombectomy endovascular therapy thrombolysis |
| title | Mechanical Thrombectomy in Cerebral Venous Sinus Thrombosis: Reports of a Retrospective Single-Center Study |
| title_full | Mechanical Thrombectomy in Cerebral Venous Sinus Thrombosis: Reports of a Retrospective Single-Center Study |
| title_fullStr | Mechanical Thrombectomy in Cerebral Venous Sinus Thrombosis: Reports of a Retrospective Single-Center Study |
| title_full_unstemmed | Mechanical Thrombectomy in Cerebral Venous Sinus Thrombosis: Reports of a Retrospective Single-Center Study |
| title_short | Mechanical Thrombectomy in Cerebral Venous Sinus Thrombosis: Reports of a Retrospective Single-Center Study |
| title_sort | mechanical thrombectomy in cerebral venous sinus thrombosis reports of a retrospective single center study |
| topic | cerebral venous sinus thrombosis mechanical thrombectomy endovascular therapy thrombolysis |
| url | https://www.mdpi.com/2077-0383/11/21/6381 |
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