PSD95 suppresses dendritic arbor development in mature hippocampal neurons by occluding the clustering of NR2B-NMDA receptors.

PSD95 suppresses dendritic arbor development in mature hippocampal neurons by occluding the clustering of NR2B-NMDA receptors.

Considerable evidence indicates that the NMDA receptor (NMDAR) subunits NR2A and NR2B are critical mediators of synaptic plasticity and dendritogenesis; however, how they differentially regulate these processes is unclear. Here we investigate the roles of the NR2A and NR2B subunits, and of their sca...

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Main Authors: Fernando J Bustos, Lorena Varela-Nallar, Matias Campos, Berta Henriquez, Marnie Phillips, Carlos Opazo, Luis G Aguayo, Martin Montecino, Martha Constantine-Paton, Nibaldo C Inestrosa, Brigitte van Zundert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0094037&type=printable

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